ALT https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2023.1065812/full Psychiatry, 16 February 2023 Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients 2. 1st-line treatment Cognitive Behavioral Therapy (CBT) with exposure & response prevention (E/RP) is one of the first-line evidence-based treatments for OCD...several meta-analyses have found a significant reduction of OCD symptoms after a psychotherapy including E/RP, with 42-52% of patients achieving symptom remission ...results should be interpreted considering potential biases, such as the exclusion from the CBT trials of patients with comorbidities or the most severe cases of OCD 3. 2nd-line treatment Taking for granted the heterogeneity in the definition of response criteria in the literature, a recent review on pharmacotherapeutic strategies in OCD suggests that only up to 50% of patients respond to SSRIs

ALT https://livrepository.liverpool.ac.uk/3172899/1/People%20with%20obsessive-compulsive%20disorder%20often%20remain%20symptomatic.pdf People with OCD often remain symptomatic following psychological treatment: A clinical significance analysis of manualised psychological interventions 32% of treated patients re-covered post-treatment compared with 3% of controls, rising to 38% & 21% respectively after 3-6 mths ...18% of treated patients were asymptomatic at post-treatment compared to 4% of controls & at follow-up...around 20% of patients were asymptomatic regardless of whether they were allocated to treatment or control conditions ...patients can be...'recovered' if they make a statistically reliable change & move from...dysfunctional to...functional...cut-off point was 12 meaning that post-treatment or follow-up scores ≤ 12 fell within functional population...Fisher & Wells: individuals with a score of 12 could still meet diagnostic criteria for OCD & experience considerable distress