Neurocritical Care Research Network | Status Epilepticus · Critical Care EEG · Acute Brain Injury | Research · Education · Collaboration | #ICTALRegistry
Joined August 2026
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🧠🌊 Welcome to IctalGroup.
We are a #NeurocriticalCare research network focused on #StatusEpilepticus, Critical Care #EEG and Acute Brain Injury.
🤝 Follow us for new studies, key publications, educational content and opportunities to collaborate. #ictalRegistry
🧠❤️ Can the brain trigger cardiac arrest?
Neurological causes account for ~3–8% of cases.
A new review explores mechanisms, diagnostic pitfalls, therapeutic implications and challenges in neuroprognostication.
📖 doi.org/10.1016/j.clineuro.2…
#NeurocriticalCare #ICTALGroup
New from the ICTAL Registry: among 952 adults with convulsive #statusepilepticus , early fever occurred in 41.2% but was not independently associated with 90-day functional outcome. Fever appeared to reflect seizure intensity more than overall severity.
doi.org/10.1007/s12028-026-0…
Post-cardiac arrest meta-analysis: strict NCSE/ESE/PSE occurred in 22% of EEG-monitored comatose survivors (112/457; 95% CI 10–41%). Poor outcome and mortality were frequent, but estimates were highly heterogeneous.
doi.org/10.3390/brainsci1609…
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How much does access to EEG matter in #statusepilepticus?
In 163 adults with EEG-confirmed NCSE, externally validated in 906 patients, longer delays to EEG were associated with worse functional outcomes and higher mortality.
doi.org/10.1136/jnnp-2026-33…
Does timing of treatment matter for neuronal injury in #statusepilepticus?
In an experimental rat model, early phenobarbital treatment prevented the reductions in N-acetylaspartate and neuronal loss observed after untreated SE.
doi.org/10.1002/epi.70448
NCSE can mimic acute stroke — including with ictal paresis.
In this 6-patient series, perfusion imaging helped identify the ictal origin when EEG findings were less informative.
A rare but clinically important presentation.
doi.org/10.1016/j.seizure.20… @phi3417 @SeizureJournal
🔥 New from the #ICTALRegistry in @GreenJournal !
How much do etiologic investigations actually tell us after #statusepilepticus — and how often do they change management?
Congrats to Sébastien Repplinger & the entire @IctalGroup team! 🧠⚡
DOI: 10.1212/WNL.0000000000218544
IctalGroup retweeted
1/ Hello #medtwitter #medsky #neurotwitter #neurosky #neurocritcare #FOAMEd #MEdEd, today we will be breaking down another article from @neurocritcarej about 🧠 O2 after cardiac arrest!
link.springer.com/article/10…
IctalGroup retweeted
The neuropathology of "dementia epileptica"
Read the full OA article on "Hyperphosphorylated tau pathology in patients with epilepsy and dementia"
on
sciencedirect.com/science/ar…
Could seizure timing predict response to IV antiseizure medications?
In critically ill patients undergoing #cEEG, greater seizure periodicity was associated with a lower probability of post-treatment remission.
Small, hypothesis-generating study.
doi.org/10.1097/WNP.00000000… #EEG
IctalGroup retweeted
Check out our newest paper here 👇🏻 doi.org/10.1002/phar.70198
Could enteral vigabatrin become an option for post-anoxic #statusepilepticus?
In 6 comatose patients with electrographic SE, loading doses achieved measurable absorption despite critical illness.
A first PK step — not evidence of efficacy.
doi.org/10.1002/phar.70198
Can non-invasive neuromodulation play a role in Super Refractory #StatusEpilepticus #SRSE ?
In a prospective series of 20 adults, adjunctive cathodal #tDCS was feasible and well tolerated; 4/20 showed short-term clinical + EEG improvement.
@BioMedCentral
doi.org/10.1186/s12883-026-0…
Could enteral vigabatrin become an option for post-anoxic #statusepilepticus?
In 6 comatose patients with electrographic SE, loading doses achieved measurable absorption despite critical illness.
A first PK step — not evidence of efficacy.
doi.org/10.1002/phar.70198
Out-of-hospital diazepam nasal spray was evaluated in 402 tonic–clonic #StatusEpilepticus episodes (>5 min): 61.7% ended before 30 min, 49.8% within 20 min of dosing, and <5% recurred within 24 h.
Retrospective pooled analysis.
@EpilepsiaJourn
onlinelibrary.wiley.com/doi/…
IctalGroup retweeted
Out of hospital cardiac arrest with successful resuscitation in the field complicates 1% of hospitalized #SAH cases. The chance of discharge with a good neurological outcome is only 5%. Mortalitty rate is >90%, and the few remaining patients are Rankin 4 or 5.
The survivors have shorter arrests, getlkess EPI, are untrensively monitored and have long ICU stays.
At least recovery os possible, justifying a fight in the ICU if the family is up for it.
#curingcoma
link.springer.com/article/10…
In 145 adults with #StatusEpilepticus, 55% developed RSE and 47% of RSE received therapeutic coma. Worse outcomes with coma were no longer significant after adjustment, highlighting strong treatment-selection effects. @EpilepsyBehavi1
epilepsybehavior.com/article…
Therapeutic coma in NonConvulsive #statusepilepticus was associated with more pneumonia, sepsis, arrhythmias, acute kidney injury and in-hospital mortality (adjusted RR 1.86), without better seizure termination
link.springer.com/article/10…
Why do some episodes of #statusepilepticus become refractory?
In 649 nonhypoxic SE episodes, acute primary CNS, progressive and unknown causes were associated with super-refractoriness. @EpilepsiaJourn
Etiologic granularity matters.
doi.org/10.1002/epi.70446
IctalGroup retweeted
🧠🌊 Welcome to IctalGroup.
We are a #NeurocriticalCare research network focused on #StatusEpilepticus, Critical Care #EEG and Acute Brain Injury.
🤝 Follow us for new studies, key publications, educational content and opportunities to collaborate. #ictalRegistry
IctalGroup retweeted
Only 19% of 273 prehospital #statusepilepticus episodes received guideline-consistent first-line treatment.
Longer delays to benzodiazepines were associated with worse hospital course
@SeizureJournal seizure-journal.com/article/…
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