PhD student in the Zwart lab | NKI | 👩🔬🧬🔬 Studying hormone-dependent cancers
Joined April 2019
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🧬1/ How do SHRs regulate transcriptional activity, and which components of the SHR-coregulator complex are essential for transcription? Our study, published in @NAR_Open, used a FACS-based CRISPR screen to dissect the GR complex. academic.oup.com/nar/advance… 🧵
Isabel Mayayo-Peralta retweeted
A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator biorxiv.org/cgi/content/shor… #bioRxiv
7/GR & PAXIP1 bind the genome, inducing enhancer-promoter interactions. PAXIP1KO reduces cohesin binding to GR-sites, impairing transcription. PAXIP1KO may disrupt insulator loops & thereby increase gene expression. A fascinating interplay between PAXIP1, STAG2 & GR!
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8/ A huge thank to my amazing promoter @zwartlab and co-promoter @Stefan_Prekovic for their invaluable guidance! Gratitude also goes to our fantastic collaborators @AHoutsmuller, @AltelaarM, and @NKI_nl and @oncodeinstitute, for their support in this research! #PAXIP1 #STAG2
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Isabel Mayayo-Peralta retweeted
Check out our new preprint - biorxiv.org/content/10.1101/…. Anyone interested in co-regulators of transcription factors should definitely take a look. This work was led by our fantastic PhD student @IsabelMayayo
Also, check this preprint by @anthonymuler! Congratulations! 🎉
Thorough preclinical validation of combined SHP2 and ERK inhibition supports clinical investigation for KRAS mutant PDAC!Next step: the SHERPA trial @lustgartenfdn @SU2C @NKI_nl @hetAVL
@SaraMainardi4 @BernardsLabora1 @schiselinski #newtherapies #PhdLife biorxiv.org/content/10.1101/…
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Really happy to share our latest work! @zwartlab @Stefan_Prekovic Check this out if you would like to know more about CDK4/6 inhibition in breast cancer! Thanks to all the collaborators for their fantastic contribution to this work ! mdpi.com/1407554
Isabel Mayayo-Peralta retweeted
Today I probably gave a most important talk of my PhD - advocating for Mental health support of PhD students. Feeling both hopeful and hopeless based on the faculty reactions. #AcademicMentalHealth @PhDchatter #AcademicChatter
Isabel Mayayo-Peralta retweeted
It’s finally out! We show that loss of nuclear LIG3 increases PARPi toxicity in BRCA1/53BP1 double-deficient cells by promoting the formation of MRE11-mediated post-replicative ssDNA gaps. Thank you to all the collaborators!
Open access share link here: authors.elsevier.com/c/1dnxa…
Pleased to share our lab’s latest work where we identify DNA ligase III as a critical suppressor of PARPi toxicity in BRCA1/53BP1 double-deficient cells. Congrats to @MarianaPaesDias who led this project in collaboration with Vivek Tripathi.
cell.com/molecular-cell/pdf/…
Isabel Mayayo-Peralta retweeted
So glad to share our review on PARP inhibitors where we discuss how resistance arises and possible strategies to overcome it! Great team work with @sarahcmoser
nature.com/articles/s41571-0…
Isabel Mayayo-Peralta retweeted
Delighted to share our new article with you! Many thanks to various collaborators that made this work possible. @NatureComms @oncodeinstitute @NKI_nl @zwartlab @timreddy @MedemaRene @liamfaller @deWitLab @AltelaarM @liamfaller and many others!
nature.com/articles/s41467-0…
Isabel Mayayo-Peralta retweeted
What happens when you try to knock out your favourite gene and find out you've actually overexpressed it? My friend @AnnaGManjon knows what's going on!
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Isabel Mayayo-Peralta retweeted
Proud to share our latest review on how glucocorticoids shape cancer biology. @EndoCancer @zwartlab @IsabelMayayo
pubmed.ncbi.nlm.nih.gov/3385…
Isabel Mayayo-Peralta retweeted
"Glucocorticoids regulate cancer cell dormancy" is the #1 paper on bioRxiv today in cancer biology. Github code (4C_mapping) supports their results. Congrats @MaxWellenstein @Stefan_Prekovic. See it at assert.pub/biorxiv/cancer_bi… + assert.pub/papers/750406. Please retweet.
Isabel Mayayo-Peralta retweeted
Glucocorticoids regulate cancer cell dormancy biorxiv.org/cgi/content/shor… #bioRxiv