Bioengineering to unlock new possibilities | Formerly PhD @MITdeptofBE (Birnbaum Lab) with a minor (major) virus obsession
Cambridge, MA
Joined October 2011
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Connor Dobson retweeted
Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells biorxiv.org/cgi/content/shor… #biorxiv_immuno
Connor Dobson retweeted
Um..🤯. Freeze dried tissue preserves chromatin for centuries!
“…we dehydrated the tissue first. The architecture was fine….Ran over it with a car, had a former Astros starting pitcher throw a fastball at it, fired a shotgun at it. Still fine.”
It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago.
🦣💨
Don’t miss our thread below! 🧵👇🏽
Connor Dobson retweeted
Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 @MEBirnbaum @kochinstitute @MITdeptofBE
biorxiv.org/content/10.1101/…
Connor Dobson retweeted
Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence biorxiv.org/cgi/content/shor… #biorxiv_immuno
Connor Dobson retweeted
Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma biorxiv.org/cgi/content/shor… #biorxiv_immuno
Connor Dobson retweeted
There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/
Connor Dobson retweeted
More healthcare gold. Now how to drive reforms that do away with this dark humor. @NPLB_org
Connor Dobson retweeted
#ASGCT2023 News: @KeloniaTx Lentiviral Particles May Solve In Vivo Delivery Hurdles for CAR T Cells genengnews.com/gen-edge/asgc… via @GENbio
Connor Dobson retweeted
Excited to share recently published work with @KelseyMWheeler and a great team looking into how mucins influence oral microbial communities!
One of the many pros of living with @chloemwu is that I now have a surprisingly deep appreciation for mucus. Read all about how mucins affect our oral microbiomes in her recently published paper! :)
nature.com/articles/s41522-0…
Connor Dobson retweeted
🧵 Here are 10 amazing things that happened this year in #biotech.🧬
Connor Dobson retweeted
Today we report a new model system for the gut microbiome: hCom2, a defined community of 119 strains. @AliceCheng107 led the charge, with major contributions from Po-Yi Ho, @DrChilennial, and @SunitJain. Co-led by my longtime collaborator KC Huang. 1/22
cell.com/cell/fulltext/S0092…
Connor Dobson retweeted
Check out our new programmable strategy for delivering genome editors to specific cell types - out today on bioRxiv 🎯
Cell type-programmable genome editing with enveloped delivery vehicles biorxiv.org/cgi/content/shor… #bioRxiv
Connor Dobson retweeted
Takeda has scored a landmark approval for its dengue vaccine, the first step in helping tackle what the WHO has defined as a top 10 health problem and cracking open a potential blockbuster market.
endpts.com/years-after-sanof…
Connor Dobson retweeted
First Sunday of Open Newbury Street is well-attended, we just wandered through the whole length, and biked back on Boylston on @RideBluebikes.
Open until 8pm today, then again on upcoming Sundays through 9/25 from 10am-8pm each Sunday.
cc @universalhub @berkie1 @jkwessel
Walking to my heart’s content. Only at #OpenNewbury. Come join for a stroll, snack or shop till 8pm today and every Sunday till the end of Sept #StreetforPeople
Connor Dobson retweeted
Not sure whether to be amused or infuriated that GOP is calling not just for defunding but total abolition of a major law enforcement agency & it won’t get even 1% of the coverage or mainstream outrage or political-price-paying as some lefty activists saying ‘defund the police.’
Connor Dobson retweeted
Biotech has been depressing lately, but some positive things have recently shown signs of life:
1. ARGX APLS raising $$ on data.
2. Hated IGMS gets a nice deal.
3. SRRA and ATRS M&A.
Connor Dobson retweeted
A good summary of the AB*56 mess, which is all bad but has a more nuanced relationship with the overall (also messy) ABeta field than is coming through in some other postings.
This Post is from an account that no longer exists. Learn more
Connor Dobson retweeted
This is not the time to dunk in people in the south/Midwest who are losing the right to a legal abortion. States like Texas are not red states, they are oppressed states. These people need your help, not your derision.
Connor Dobson retweeted
So I guess the CDC & FDA snoozed through their massive testing f*ck-up in Dec-March 2020 and decided to change nothing. #PandemicUnpreparedness
I have spent the last 24 hours trying, with every contact, I have, to get someone I know tested for Monkeypox; his case is TRAVEL ASSOCIATED with KNOWN RISK FACTORS, and still @nyulangone refused to test his "abnormal HPV-like lesions" because they're internal.
Connor Dobson retweeted
I am thrilled to share our newest preprint, in which we describe how Jnk and Erk act as pro-senescence pathways after DNA damage! This work represents a big chunk of my PhD project in @MITdeptofBE, and I am excited to share it with you all (a 🧵) (1/21)
biorxiv.org/content/10.1101/…
