Harvard Medical School | Brigham & Women’s Hospital | Biochemist and Dermatologist | Former : Harvard Combined Derm Residency | Duke | Univ. of WA
Boston, MA
Joined December 2016
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GPCRs are the target of ~30% of medications. Cells use G proteins and β-arrestins as communication pathways. We show these proteins can interact directly, revealing that GPCR signaling is more connected than previously understood.@MGBdermatology @HMS_BCMP nature.com/articles/s41467-0…
Jeffrey S. Smith retweeted
The Stephen Rothman Memorial Award is the Society for Investigative Dermatology's highest honor, recognizing distinguished service to investigative cutaneous medicine. This year's recipient is our very own, Dr.@ThomasKupper3!
Congrats on this prestigious and well-deserved honor!
Congratulations to @BobbyHollings and @beccajcarlson on their launch of @deliverome! Excited to collaborate with them and see where their efforts to map the cell-surface receptor proteome land! ifp.org/the-deliverome-proje…
Excited to share a project using AlphaFold-guided design to identify functional nanobody binders to the itch receptor MRGPRX2! Excited about this and other computational approaches
Grateful to all especially leads @epharvey3 @katherine_susa nature.com/articles/s41467-0… @NatureComms
Jeffrey S. Smith retweeted
Dr. @JSmithMDPhD & Dr. Andrew Kruse will be featured tomorrow at Guppy Tank (5/7, 4–6PM) at LabCentral in Cambridge, MA, presenting: Beyond Sunscreen: A Targeted MC1R Agonist for Sunless Skin Pigmentation & Skin Cancer Prevention. Address listed below:
📍 700 Main St, Cambridge
Great talk by @JosephMerolaMD at RDS sharing compelling benefits of litifilimab for treating patients with cutaneous lupus and lupus!
Jeffrey S. Smith retweeted
The 117th and final pitch of Garrett Crochet's night went 100.2 mph, tied for his fastest of the season. He finished with 11 strikeouts, didn't walk anyone and exits with a 2-1 lead for the Red Sox. The first playoff start of Crochet's career was brilliant.
Jeffrey S. Smith retweeted
Interested in doing a postdoc at DFCI/Harvard on computationally designing and experimentally characterizing mini-protein binders for biomedical applications? Eric Fischer and I are looking for someone to work in our groups starting asap! Email me or my admin with a CV to apply!
Jeffrey S. Smith retweeted
Congratulations to @ThomasKupper3 on being awarded the Stephen Rothman Memorial Award! 🏅
This award is the Society for Investigative Dermatology’s highest award and recognizes an individual who has distinctly altered the course and image of dermatology or its allied fields.
Jeffrey S. Smith retweeted
Our proteomics group is looking for a Scientist who is excited to push the boundaries of chemoproteomics and interactomics at Dana‑Farber!
Apply at the link or message me with questions! careers.dana-farber.org/job/…
We are excited to share a preprint detailing biochemical and cellular evidence for direct interactions between G proteins and beta-arrestins, two proteins critical to the function of G protein coupled receptors. biorxiv.org/content/10.1101/…
As G protein coupled receptors are the target of ~30% of all FDA approved medications, new pathways critical to GPCR signaling shape not only our understanding of how cells respond to hormones and other stimuli, but also can help guide drug discovery efforts.
This work was made possible thanks wonderful institutions and colleagues across the USA including @SudarRajagopal @lab_tall @BlacklowLab. Thank you to @NIH, @NIH_NIAMS, and USA taxpayers for supporting this research. @HMS_BCMP @BrighamWomens @bwhdermatology @dukebiochem
A wonderful visit! Thank you for sharing outstanding science and incredible hospitality. @UTSWDerm is clearly an excellent home for physician-scientists. Special thanks to @JosephMerolaMD for the invitation to share my research!
We were thrilled to host Dr. Jeffrey S. Smith (BWH/HMS) for Wednesday’s UTSW Derm research seminar!
He shared insights on GPCR signaling in dermatology, an exciting look at the molecular mechanisms shaping our field.
#UTSWDerm #Dermatology #Research
Jeffrey S. Smith retweeted
We were thrilled to host Dr. Jeffrey S. Smith (BWH/HMS) for Wednesday’s UTSW Derm research seminar!
He shared insights on GPCR signaling in dermatology, an exciting look at the molecular mechanisms shaping our field.
#UTSWDerm #Dermatology #Research
Jeffrey S. Smith retweeted
Excited to share that our EndoMap project is now out! A fun collaboration with Miguel Gonzalez-Lozano from the Harper lab. Read about our #AlphaFold structural interactome of XLMS identified complexes in endosomes-> nature.com/articles/s41586-0…
Jeffrey S. Smith retweeted
Huge thanks to all!😊
Happy to share our work on the allosteric regulation of FFA2 receptors! It was a great collab. with the Ishikita, @DrorLab, and @TohokuSeika labs. Congrats to Mai, @kk_kawakami, Ryoji, and everyone involved!
nature.com/articles/s41467-0…
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Jeffrey S. Smith retweeted
Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions dlvr.it/TJgZXl
Jeffrey S. Smith retweeted
On behalf of our faculty, residents, staff, and administrators, it is truly a privilege to welcome these exceptional future trainees into our program, community, and family! #derm #dermatology #MatchDay2025
