JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave) header
JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave) profile picture

Deep Tech Optimist 🚀, Network State Maxi 🌐 Relentless Champion for $BTC , DeFi, DeSci, & DAOs 💪 🛑DYOR ✋NFA🤑

Próspera, Roatán 🏝️
Joined June 2008
Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)Photo by JH (Open 🕸️, 📖s, 💞s, 🧠s) (@JasonHartgrave)
JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Today, Pioneer Labs is announcing our first step towards terraforming Mars. 🚀🌼 With equipment that fits in just a single rocket launch, we can convert Martian dirt, water, and air into enough building materials to construct a small city on Mars. To do it, we made the first microbe for Mars. We found the best microbe on Earth and used evolution to teach it how to source all of its nutrients directly from Martian materials. The first astronauts will be greeted with safe shelter already filled with water, oxygen, and rocket fuel for the return journey. This is the first step toward using biology to make Mars a friendly place for life. It lets us live off the land and helps us build the next great frontier. It's the first of five organisms we need to green Mars ⬇️
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
This is a major milestone in the age of AI and toward our ultimate goal of completely reversing aging! @InSilicoMeds developed the first AI drug, Rentosertib, now in a Phase 3 clinical trial, and it just showed something remarkable: a reversal of biological age in people! Six different aging clocks, developed by six independent groups, all showed reversal after just 12 weeks of treatment, with participants measuring 3–4 years younger biologically! Congratulations to my friend Alex and the entire @InSilicoMeds team on this landmark achievement!
My dear friends, I am happy to report the publication of the most important paper in my life to date (we have several great papers coming out but this is very special). Tomorrow, I will present this paper for the first time at the Nature AI Healthcare in Paris and will post a longer post on this story and its broader implications for how to conduct clinical trials. Please read it and comment on it. Many thanks to the great co-authors of the study and everyone who contributed. Many thanks to the many reviewers (friendly and unfriendly) for spending so much time and helping make it better. Link in the comments.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Congratulations @niroshajmurugan and everyone else whose work was covered - a really important field! It deserves much more focus.
You emit light. Expanding biology beyond molecules allows us to consider another layer of life: how energy, including light, may reflect and perhaps help coordinate biological activity. Thank you to @JoMarchant and @Nature for featuring our work alongside other leaders in the field, and for opening a broader conversation about what might be possible, the tools we must build, and the next generation of scientists we must train. Now, we have the opportunity to determine what the light of life is telling us.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
dear new X algo show this to the builders and investors accelerating biology with AI and robotics the ones who: - read clinical trial data for fun - have strong opinions on FDA approval pathways - think in terms of biological age, not chronological age - know what a wet lab actually is - get excited about boring infrastructure, not just flashy drugs - have already funded or built something most people would call insane - see longevity as an engineering problem, not a fantasy - ask about regulatory risk before they ask about the science - would rather back the narrow disease-specific wedge than the grand vision pitch - already missed one wave and don't plan on missing this one we sign checks in one hand and pipette in the other, DM. bio/acc
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Looking for a SuperHuman Fund intern. Do you obsess over peptides? Dream of artificial wombs, embryo selection, continuous hormone optimization, longevity injections, BCIs? - Low pay - Long hours - Chances of achieving immortality 46% - Exposure to insane frontier bio deal flow 700% - Escaping the permanent underclass off the charts Apply now.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
The Midjourney scanner is revolutionary. There’s a bullish case that exceeds the most optimistic takes. I was at the unveiling and used the scanner myself. I personally want to experiment with a weekly whole body Midjourney scan to add to my 1.5 billion data points and let my AI and doctors start connecting the dots. Most of the early commentary has focused on the wrong questions: “is it as good as MRI?” and “what about false positives?” These are legitimate concerns, but they miss the bigger shift. The more important question is: what does fast, low cost, safe whole body imaging unlock? Let’s start with measurement. A speedometer tells you how fast you are going. A fuel/battery gauge tells you when to stop. A thermostat tells you what to wear. The stock price tells you how much money you’ve made or lost. We measure what we care about. Except, oddly, for our bodies, which are among the least measured things in our lives. Most people have more data on their favorite sports team, bank account, and social media performance than their body. The future will think we were crazy for this. The first law of medicine is to do no harm. Our current system has harm baked into it. + an undiagnosed condition progressing silently is harm + a doctor who can’t easily get a patient screened preventively is harm + having no baseline to compare against when something shows up is harm Our preventive net is narrow and inconsistent. Late stage diagnoses that could have been caught earlier remain common. Midjourney’s technology won’t eliminate that overnight, but it points toward a future where routine wholebody baselines become normal rather than exceptional. Midjourney can help flip harm-by-default into a new expectation for our health infrastructure: almost no one will ever again be blindsided by a late-stage, life-threatening diagnosis that could have been caught earlier reasonably and cost-effectively. Some examples of what earlier structural visibility enables: + breast cancer caught while localized has a ~99% five year survival rate. Once it has spread distantly, that drops to around 32%. + an abdominal aortic aneurysm kills more than 8 in 10 people when it ruptures. A single ultrasound finds the aorta in 99 percent of people, and screening cuts aneurysm deaths by a third to a half. Midjourney’s technology will not do it all on its own. Its full angle, water immersion approach works around bone rather than seeing through it, and routes bowel gas to image the full abdominal cross section. Yet two real limits remain: air filled lungs stay a blind spot even here, and the brain is out of reach behind the skull, beyond the torso and legs this scanner covers. That is fine, and they may improve these areas over time. Midjourney doesn’t need to do it all in order for it to be one of the biggest things to hit medicine in a long time. Let’s look at where specifically Midjourney may be useful to each of us. We’ll start with where we get data today: 1) Blood draws tell us what is happening chemically. 2) Wearables tell us how the body is functioning. 3) Imaging tells us what is happening structurally. The third layer, soft tissue, is the one we have never been able to access easily. MRI is great, but it is expensive, intimidating, and slow. Midjourney's technology excels with soft tissue. Here are three places it could be game changing. There are many more. 1. Metabolic health - fatty liver is one of the earliest structural signs of metabolic dysfunction. It’s strongly linked to insulin resistance, type 2 diabetes, and cardiovascular risk. Being able to track visceral fat, muscle fat infiltration, and liver fat over time could give a much clearer picture than blood markers alone. Over 88% of Americans are metabolically unhealthy. 2. Endocrine tissue - the same metabolic patterns often cluster with thyroid issues, PCOS, and hypogonadism. Ultrasound can directly image the thyroid and ovarian structures. Fat tissue itself is an endocrine organ, so tracking it structurally adds another useful data layer. 3. Soft tissue + multiomics - new proteomic aging clocks can already predict risk for many chronic diseases from blood proteins. These molecular models could become significantly more powerful when combined with actual structural imaging data. The two are complementary, not competitive. The real advantage: baseline + longitudinal tracking The biggest unlock isn’t a single scan. It’s having a baseline followed by regular follow-ups. A one off scan in a moment of concern turns every finding into a potential crisis. Without context, you have no idea whether something is new, stable, or changing. With baseline + repeated measurement, the question changes from “what is this?” to “is this changing?” Most incidental findings stay stable. The dangerous ones tend to grow or evolve. Trajectory is often more informative than any single image or timepoint.This is why false positives become more manageable with frequent, low-friction imaging. Midjourney has a difficult road ahead. Building robust, clinically validated medical hardware and software is extremely hard. Regulatory, technical, and adoption challenges shouldn’t be understated. Also, David is doing this for the right reasons and he’s well positioned financially to push through the difficulty. On the horizon We are moving quickly into a future where we will have continuous biological measurement. It will be all around us, a lot of it invisible and autonomous. Measurement will be in our gyms, beds, homes, clothing, offices, cars, glasses, and wearables. It will also be inside of us, in tissue and circulating in our blood vessels. This moves us from managing crises to preventing them. But this future will not just show up. We need bold builders like David and his team, willing to do the hard work.
A technical dive inside our new "Midjourney Scanner"
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Ha sido especial ver de primera mano el cambio cultural en Roatán en cuanto a la adopción de Bitcoin y cripto en general. Encajó muy bien con la base cultural. Calculo alrededor de 120 negocios aceptan BTC o cripto, y los que no lo aceptan formalmente igual conocen a alguien que pueda ayudarles a recibir un pago en cripto de ser necesario. En 2021 eran 2 lugares. Recuerdo que organicé el Bitcoin Pizza Day en 2022. Ahora ni tengo qué pensar en ello, hay comundidades dedicadas a educación organizando actividades regularmente, lideradas por @AmityAge. Hay ATMs de BTC, y la isla se ha convertido en un Hub en el Caribe para estos temas.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Ever wanted to talk to a gene regulatory network? Ever wonder what they could do in a different context, embodiment, space? New #preprint! @YanboZhang3 "Language Game: Talking to Non-Human Systems" arxiv.org/abs/2605.16321 An early step in our program of developing ways to talk to organs, cells, molecular networks, and far weirder kinds of agents.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Who's really trading on Stabull? 🤖 Our latest feature in @BraveNewCoin breaks down why bots, solvers, and aggregators favor our DEX for execution. From oracle-anchored pricing to high capital velocity—we're built for efficiency. Read more: bravenewcoin.com/insights/bo…
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Stabull surpasses $20M in cumulative volume! 🥳 This week also brought a new daily volume ATH, with $737,889 traded through Stabull pools on Monday, 23 March 🔥 Plus, the Pools page has been updated — you can now view APR from fees side by side with any liquidity mining rewards! Strong momentum. More to come 🚀
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
We’re hosting the Liberty Acceleration Summit in @ProsperaGlobal: → the zero-to-one, liberty-aligned, pro-technology jurisdiction Want to see how these zones actually work? Come experience it firsthand 👇
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Governance HAS ARRIVED! 🚀 Your voice now steers the protocol. Holders can influence: ✅ DEX parameters ✅ Commodity swap pools ✅ Fee distributions Phase 1 is live. Get the full details here: 👉 stabull.finance/defi-blog/in…
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Imagine picking your legal system the same way you pick a cloud provider. @Prosperahn is doing exactly that. A true launchpad for network states.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
🇦🇺 AUDD is now live on Stabull DEX! The Australian Dollar stablecoin issued by @audd_digital is now tradable via the AUDD / USDC pools on Base and Ethereum. Since launching just a few weeks ago, the Base pool has already seen over $220k in swap volume. 🧵👇
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Replying to @etherfuse
@Etherfuse is one of the most innovative teams we’ve worked with. Stablebonds are a game changer and instant FX settlement is a much needed real world use cases. 🐂
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Governance is becoming a market. People will choose societies the way they choose platforms. @ProsperaGlobal is one of the first real experiments in a network state. Why is the Reality team there? 🧵👇
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
Hair grows slowly and results are noisy. Unlimited Bio’s CEO Ivan Morgunov committed for a disciplined N-of-1: a split-scalp test where one half gets local VEGF #genetherapy, the other half gets placebo.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
🗣️ DEBATES BATTLE 🗣️ We teamed up with @SuperDebateClub to host a Debate Battle! Founders, thinkers, and misfits will go head-to-head in rapid-fire rounds on the future of tech, society, and everything in between. Fast, sharp, and way more fun than your college debate club.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
The Stablecoin market is ripe for disruption: In just 9 months in 2025, Tether ALONE reported $10 BILLION in profit from $USDT. How is this possible? Tether reported $137 BILLION in US Treasury holdings, making the company the 17th largest holder of US debt. Tether takes the capital "invested" in $USDT, lends it to the US government, and collects the yield. Stablecoin holders are effectively "lending" Tether capital at a 0% interest rate, which is then flipped on Treasuries. Leading onchain innovation, Jupiter already launched $JUPUSD, the first onchain-focused Stablecoin designed to return this yield to ecosystem. The Stablecoin yield model is changing.
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JH (Open 🕸️, 📖s, 💞s, 🧠s) retweeted
A strong opening for the third edition of our pop-up experience in Roatán! Close to 100 attendees, interested in knowing what can be built with the @infinitacity platform, and in the things happening in @ProsperaZEDE. And it will continue to grow during these 2 months. This weekend we have the Principled Business Summit and the Longevity Biomarkers Conference both happening on the island!
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