8/ Now step all the way back and see the shape of the whole thing, because this is the part that gave me chills. Every one of these breakthroughs runs on the same underlying toolkit — and it's the exact same toolkit that let us produce COVID vaccines in a matter of months instead of years: messenger RNA, lipid nanoparticles to deliver it, rapid genetic sequencing to read biology, CRISPR to rewrite it, and now AI to design it. Five technologies that all matured at once, in the same decade, and are now being aimed, together, squarely at the two diseases that kill more human beings than anything else: cancer and heart disease. That's the revolution hiding inside four "stock stories." We are watching medicine pivot on its axis — from reacting to disease after it has already declared itself and done its damage, to programming the immune system and the genome to stop it before it can win. From treating the average of a population to writing a prescription for a single, specific human being. From a lifetime of managing illness to, potentially, durable one-time interventions against its root causes. That is not an incremental improvement. That is a different philosophy of what medicine even is.

More Americans believe we’ll colonize the moon before we fix K-12 education. This is a policy problem. We have been building a solution that’s already trusted by many of the Fortune 500 as well as 1/3 of federal and state elected officials in the United States. Organizations are more impacted by policy than by financial markets. Yet financial markets have been real-time for decades, and policy markets are still nearly impossible to follow. @StateAffairsUS has raised over $70M from @rabois, @khoslaventures, @foundersfund and others to fix that. We are creating the world’s first real-time knowledge graph for policy and regulatory markets. This platform is foundationally built on non-partisan journalism and the collection of on-the-ground data that isn’t digitally accessible. In the future, we believe every executive will watch policy markets the way they watch financial markets. Instead of reacting to regulation, they’ll navigate it proactively. Policy should iterate at the speed of our most innovative industries.

I just started work at @Underdog where I will be building the best exchange for sports fans. While opportunities in prediction markets are incredibly wide, the decision on where I wanted to work next was easy. The companies that will define this space long-term are the ones that know how to navigate changing regulatory structures, have a genuine obsession with building great products, backed by a record of doing so, and have a user base that already trusts them. Underdog hits all three markers, and I'd argue no one surpasses the company in any of the three categories. Further, Underdog is one of the only sports companies in the country that holds all three major CFTC licenses: DCM, DCO, and FCM. These licenses are a challenge to acquire and take time, capital, and regulatory credibility. Most companies in this space have one and piggyback on a partner who has another. Underdog went out and developed what it needed to operate independently and at scale, and that signals something important about where this company is headed. Underdog has been designing innovative products their customers obsess over for a long time and across multiple categories and regulatory regimes. They don't operate with any sanctimony about what the rules should be; they find ways to make incredible products for their customers within the relevant rules and regulations. Before they even had their own prediction market exchange, they figured out how to combine a federally regulated event contract with player picks from their fantasy product. At the time, this delivered a same-game parlay-like experience before anyone else. When I saw it, I knew I needed to talk to them, as this kind of creative problem-solving is exactly what separates good operators from great ones. Now, after the acquisition by IG Group, Underdog has even more firepower. We'll be able to leverage their expertise and resources to expand what's been created here to more customers, and keep building more incredible products. @JerLevine is another major reason I think Underdog has a real shot to lead this space. I've watched founders try to navigate prediction markets, and it's genuinely hard. The regulatory complexity, the product challenges, and the competition from companies with bigger balance sheets can turn it into a gauntlet. Jeremy has led Underdog through these challenges, and just does things the right way. Regulated markets and responsible gaming aren't afterthoughts here, they're baked into how this team operates. I'm excited to bring what I have learned to Underdog and help build at the most interesting company in prediction markets right now.

it's not every day a guest does a CNBC interview live from your wedding but if anybody was gonna do it, @JerLevine was the -5000 favorite. congrats to all the legends at underdog on the launch of their exchange, they are absolute killers!

Josh and Hayden’s influence in how fantasy content has been produced and consumed in the last few years has been massive. Not surprised Underdog is making this move, just sucks to see. Wherever they land, or if they start their own thing, it’ll be massive & even better.

Hey friends. I haven’t been as active the last couple weeks because I was sick and in the hospital. Here is why: I am usually someone to proud to ask for help but unfortunately I need it now. I had a kidney transplant in 2018 and unfortunately need another one now. I am on Dialysis treatments and I feel great but to get back to living a normal life I need a kidney transplant. Please consider being a Living Kidney Donor! Click on the Vanderbilt Health link and complete the Living Donor Interest Form. You will list Hope Bishop as the name of the person you want to donate to. Also, please select YES on being a paired donor if necessary. vanderbilthealth.com/program…