jp retweeted
(1/2) How is epigenetic memory maintained across generations? 🧬 Our latest study reveals the role of SET-24, a SET domain-containing protein in C. elegans, in preserving germline integrity and small RNA-driven epigenetic silencing. Read more in our preprint!!
Delighted to share our latest preprint on the catalytically inactive SET domain protein SET-24 and its interactor, HCF-1, in maintaining transgenerational epigenetic memory, regulating histone modification and small RNAs. @ericmiskalab biorxiv.org/content/10.1101/…
jp retweeted
Just in case anyone is still here, check our latest preprint, right on time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes.
biorxiv.org/content/10.1101/…
Short 🧵 with highlights.
Transposable elements drive regulatory and functional innovation of F-box genes biorxiv.org/cgi/content/shor… #biorxiv_evobio
jp retweeted
How does AlphaFold3 predict the structures of proteins, DNA/RNA, ligands and other biomolecules? I did a deep dive into protein folding, how AlphaFold works and the new model. Here’s what I learned:
(resource in thread)
jp retweeted
$ENVX …. 👀 This was a well done spaces.
I didn’t expect to speak but appreciated being invited to share my thoughts.
I shared a number of insights in addition to providing a detailed overview of my thesis.
@EnovixBatteries
unavailable
rnaCrosslinkOO is out in @OUPBioinfo!
doi.org/10.1093/bioinformati…
An easy to use @_R_Foundation package designed to analyse RNA cross-linking data. Raw reads to comparison of predicted structures. Data is available so please check out your favourite RNA. 1/3
We show experimental evidence for in silica predictions of EEF1A1P5. As well as benchmarking against the 18S rRNA. 2/3
As usual this is team effort! A huge thanks to everyone in @ericmiskalab. The authors - @Jon_LP, @omerz213, @ericmiska, Malte Pickert and Andrew Lim.
See what it can do 🤗
@CRANberriesFeed @RNAStructureBot #RNA #RNAStructure 3/3
jp retweeted
🚨New preprint alert!!🚨 I am delighted to share my first postdoc research paper on the interaction between transposable elements (TEs) and piRNAs in African cichlid fishes 🐠🐠
Link here: biorxiv.org/content/10.1101/…
Find the highlights in 🧵
ALT An Astatotilapia calliptera male. Credit: M. Emília Santos
jp retweeted
So excited to bring my contemplations on #lncRNA role in #lungcancer and #lungdevelopment to #RNAUK2024 🤩🤩 Thank you for the opportunity! – at North West, England
jp retweeted
Great start to #KSRNAMod24 Keystone RNA modification meeting in amazing Banff 🏔️😎 #RNA #Epitranscriptomics
jp retweeted
Very happy that my first contribution to the cichlid community is out🐠🐟🐠. This review was the outcome of the Genome editing workshop at @Cichlid2022. We hope it will be useful for the community! Check @_Bethan_Clark's thread for details.
Excited to say our review of genome editing in cichlid fishes, focusing on CRISPR/Cas9 tech, is now published in @RSocPublishing #OpenBiology!
Link here: royalsocietypublishing.org/d…
Some highlights in🧵
ALT A screenshot of the title "Genome editing in East African cichlids and tilapias: state-of-the-art and future directions | Bethan Clark, Muktai Kuwalekar, Bettina FIscher, Joost Woltering, Jakob Biran, Scott Juntti, Claudius Kratochwil, M. Emilia Santos, and Miguel Vasconcelos Almeida"
jp retweeted
@migueldvalmeida @ericmiskalab @CamBiochem speaking at the Dark Matter of the Genome session about his work on TEs in cichlids 🐟🐠🐡
jp retweeted
Help! Looking for a Comms coordinator to work with me and the team at @CamBiochem @Cambridge_SBS @Cambridge_Uni. Please RT!
jp retweeted
Hot off the pre-press🔥 #Chromatin
tinyurl.com/efwe4je7
We provide the first evidence that inhibition of UBR-5 or HECD-1 can restore development to adulthood in #Celegans SWI/SNF mutants that otherwise die as embryos or arrest development at early developmental stages.
A 🧵:
jp retweeted
Very excited to start my new role as Head of the Department of Biochemistry at the University of Cambridge @CamBiochem @Cambridge_Uni. More news to follow shortly. 😄
jp retweeted
LiquidText (liquidtext.net) - This is where I keep all my PDFs and notes on books/whitepapers/blogs etc, I have workspaces for things I'm interested in "appsec, APIs, etc...",you can 'pull out' text from different sources and visually place it together w/ your notes
jp retweeted
1/ Do you want to know if a variant will affect the structure and function of a protein?
We’ve got lots of tools and #data in @ensembl to help you investigate and we’re here to show you how! A thread...🧵
#genomics #bioinformatics #tweetorial #Ensembltraining🧬
