Reprogramming cells for fun and to create embryo models in the tropical Greater Bay Area. @josesilvalab.bsky.social 🇵🇹🇨🇳🇬🇧
Guangzhou/Cantāo 🌴☀️, China中国
Joined June 2018
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Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you.
José Silva & Lab retweeted
In the latest issue! A complete model of mouse embryogenesis through organogenesis enabled by chemically induced embryo founder cells dlvr.it/TNlqDB
José Silva & Lab retweeted
🚨Jobs alert:
Want to join our growing team, working on epigenetics in stem cell models of reproduction and pluripotency?
We are looking for enthusiastic new lab members as part of the Postdoc, PhD, and MSc student recruitment campaign of our centre: event.fourwaves.com/campagne…
José Silva & Lab retweeted
Raising the bar for human post-implantation embryo models dlvr.it/TNWCnC
José Silva & Lab retweeted
Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling dlvr.it/TNRG9l
José Silva & Lab retweeted
Our October issue is live! The cover highlights several papers reporting advances in stem cell-derived embryo models with a timeline of the rapid development of this field. cell.com/cell-stem-cell/curr…
José Silva & Lab retweeted
Honored to see our paper featured on the journal cover! The cover image highlights how the morphological complexity of human stem cell-based embryo models (SCBEMs) has advanced over the past decade.
Our October issue is live! The cover highlights several papers reporting advances in stem cell-derived embryo models with a timeline of the rapid development of this field. cell.com/cell-stem-cell/curr…
José Silva & Lab retweeted
Scientists investigated whether STAT3 activation can reprogram pluripotent stem cells into early fates that self-organize into embryo models.
🔎 Discover their findings in @CellStemCell: bit.ly/4pL1M8v
José Silva & Lab retweeted
Online Now! Signaling reprogramming via Stat3 activation unravels high-fidelity human post-implantation embryo modeling dlvr.it/TN6Gw9 #stemcells
(1/8) Very Happy to share our lab’s 3D post-implantation human embryo model, made via signalling reprograming!🙌 Huge thanks to the entire team and our collaborators, special shout-out to Chen Chuanxin (led the work) and Wu Jinyi (computational analysis).
cell.com/cell-stem-cell/full…
(1/3)A while back, my then-PhD student @H_T_Stuart stumbled on a finding that changed our lab’s direction 👀✨. Turns out, STAT3 mediated reprogramming generates intermediates (Gata6GFP+ cells) going through an earlier developmental stage with increased developmental potential 🚀
(2/3)… this was actually a side finding in that study🙃
cell.com/cell-stem-cell/full…
However, we thought this could be paralleling early embryo development and have since been exploring it to generate embryo models.
(3/3) Fast forward ⏩ @PandaChuanxin @jywu_wu et al. investigated this in human cells. Curious to see what they pulled off? Stay tuned!
José Silva & Lab retweeted
💓 New in @CellCellPress: Researchers at Guangzhou Medical University used #SmallMolecules to convert mouse ESCs into embryo founder cells, which generated a complete embryo model!
Article: bit.ly/4orpbLb
Episode with discussion: bit.ly/4636dn3