@barra_lena @goetheuni @LacknerLab @andexerlab @HelgeBode_Lab @DoraTang5 @erblabs @RussellCox_Chem @Helfrich_lab @HNiederho @Grininger_Lab

On bioRxiv: Adenylation multispecificity guided us to find broad evolvability of #nonribosomal surfactin synthetase SrfAC. Provides guidelines which enzyme residues have potential for bioengineering #antibiotics. Congrats Aleksa! @LeibnizHKI @SvenssonCarl bit.ly/3LqOJoD

Did you know that an artwork of Beuys once got mopped up by accident? Indiscriminate cleaning up of biosynthetic intermediates can be a loss or a benefit for engineered #NRPS as shown by Farzaneh&Sayan in ACS Chem Bio. @LeibnizHKI @KriesLab @Hertweck_Lab bit.ly/3B779qX

Congrats Jacob Wurlitzer & Markus Gressler! We recorded substrate profiles in this exciting project on fungal #NRPS. Knowing side-activities helped to develop a biosynthetic strategy for fluorophore-labeled peptides. @LeibnizHKI @ChemicalScience @UniJena doi.org/10.1039/D2SC00860B

Please share! Our young team of biosynthetic designers @LeibnizHKI (Jena, D) is looking for a postdoc with experience in handling RNA. Thanks to the Boehringer Ingelheim Foundation for the Exploration Grant. More info in the job offer below & upon request. bit.ly/3FhnNEO

Congratulations to Aleksa Stanišić, who is the first student from our group @LeibnizHKI who has defended his PhD. You have done amazingly well in your defense and we wish you all the best for the future!

Who decides product specificity in nonribosomal assembly line synthesis? The answer is important for making new antibiotics through #NRPS engineering. Now out @ACSCatalysis. bit.ly/3yeXuKH Thanks to our collaborators @david_niquille & J. Reinstein @mpi_mr_hd. @LeibnizHKI

You can force a viral protease to dig its own grave. Catalytic promiscuity of 3C protease generates protease inhibitors that are molded into the active site. Great paper in @angew_chem by @RademannLab. doi.org/10.1002/anie.2021020…

In #NRPSs, engineering creates mismatches between adenylation and condensation specificity. Our kinetic model explains product specificity under substrate competition. Adenylation wins! Thx J. Reinstein @mpi_mr_hd, @david_niquille & my group @LeibnizHKI doi.org/10.26434/chemrxiv.14…

A preprint from the Cryle group @MonashBDI shows beautiful #xray structures giving new insights into condensation domain mechanism&specificity of nonribosomal peptide synthetases.#NRPS Important for bioengineering new #antibiotics ! researchsquare.com/article/r…