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Your HPLC DataBase

@LC_Analysis

Get interesting information about Liquid Chromatography and Mass Spectrometry - For free! #OpenAccess #OpenScience

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Joined October 2013
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A simplified EMR-Lipid cleanup strategy coupled with UPLC-MS/MS for determination of legacy and emerging PFAS in eggs: Method validation and greenness assessment | Analytical Methods | The Royal Society of Chemistry share.google/iQCiE00uicQD08T…
A simplified EMR-Lipid cleanup strategy coupled with UPLC-MS/MS for determination of legacy and...

A simplified EMR-Lipid cleanup strategy coupled with UPLC-MS/MS for determination of legacy and...

Reliable monitoring of per- and polyfluoroalkyl substances (PFAS) in food matrices requires simple and sensitive analytical workflows, particularly for lip

pubs.rsc.org
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A High-Sensitivity and High-Throughput LC-MS Workflow for Low-Input and Single-Cell Proteomics | bioRxiv share.google/3f5Ynlp6xslUKhN…
A High-Sensitivity and High-Throughput LC-MS Workflow for Low-Input and Single-Cell Proteomics

A High-Sensitivity and High-Throughput LC-MS Workflow for Low-Input and Single-Cell Proteomics

Single-cell proteomics (SCP) requires sample preparation that minimizes sample loss and highly sensitive LC-MS analysis because the amount of protein available from a single cell is extremely...

biorxiv.org
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Debunking Myths and Half-Truths in HPLC and Pharmaceutical Analysis | LCGC International share.google/P4f171Ur4GMmMDx…
Debunking Myths and Half-Truths in HPLC and Pharmaceutical Analysis | LCGC International

Debunking Myths and Half-Truths in HPLC and Pharmaceutical Analysis | LCGC International

"Perspectives in HPLC" examines 5 long-held HPLC "rules" (mobile phase filtration, routine buffer use, avoiding pH near an analyte's pKa, defaulting to 4.6-mm columns, and relying on AI for early...

chromatographyonline.com
26
Towards reducing back-exchange in hydrogen-deuterium exchange mass spectrometry: a feasibility study of sub-zero digestion and nano-LC separation. link.springer.com/article/10…
Towards reducing back-exchange in hydrogen-deuterium exchange mass spectrometry: a feasibility...

Towards reducing back-exchange in hydrogen-deuterium exchange mass spectrometry: a feasibility...

Analytical and Bioanalytical Chemistry - In recent years, hydrogen-deuterium exchange mass spectrometry (HDX-MS) has emerged as the method of choice for characterizing increasingly complex protein...

link.springer.com
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Development and Validation of AQbD-Driven Bioanalytical UFLC Method for the Quantification of Acyclovir in Human Serum: A White Analytical Chemistry Approach link.springer.com/article/10…
Development and Validation of AQbD-Driven Bioanalytical UFLC Method for the Quantification of...

Development and Validation of AQbD-Driven Bioanalytical UFLC Method for the Quantification of...

Journal of Pharmaceutical Innovation - Acyclovir is a prevalent prescribed antiviral drug, while in selected patients, it may require routine therapeutic drug monitoring attributed to...

link.springer.com
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Analytical approaches for the determination of vardenafil in various matrices: a review link.springer.com/article/10…
Analytical approaches for the determination of vardenafil in various matrices: a review

Analytical approaches for the determination of vardenafil in various matrices: a review

Chemical Papers - Vardenafil (VAR) is a potent phosphodiesterase type-5 (PDE-5) inhibitor widely used to treat erectile dysfunction. After oral administration, it undergoes hepatic metabolism via...

link.springer.com
66
Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) for the Determination of Acrylamide in Grains and Grain-Based Products | Springer Nature Link share.google/sa4XGbtD23Y9Tz3…
Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC

Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC

In recent years, the presence of acrylamide (AA) in food has been a cause of concern, since it has been classified by the IARC as probably carcinogenic to humans (Group 2A). Within the EU, benchmark...

link.springer.com
57
Highly Sensitive LC-MS/MS Method for Determination of Hymexazol Residues in Sugar Beet share.google/vzW1HUFhyMJU3Xm…
Highly Sensitive LC-MS/MS Method for Determination of Hymexazol Residues in Sugar Beet

Highly Sensitive LC-MS/MS Method for Determination of Hymexazol Residues in Sugar Beet

This study developed a detection method for hymexazol residues in sugar beet, targeting its low molecular weight, high polarity, and lack of chromophores. The method optimized mass spectrometry...

mdpi.com
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From Grapevine Tissues to Proteome Coverage: Analytical Workflows for Protein Extraction, Fractionation and Mass Spectrometry share.google/rItw8dWvFzUtIJ2…
From Grapevine Tissues to Proteome Coverage: Analytical Workflows for Protein Extraction, Fractio...

From Grapevine Tissues to Proteome Coverage: Analytical Workflows for Protein Extraction, Fractio...

Grapevine (Vitis spp.) proteomics is an important tool for investigating berry development, stress responses, dormancy, root adaptation and extracellular defense processes. However, many grapevine...

mdpi.com
60
Stable Isotope-Assisted Liquid Chromatography Mass Spectrometry Reveals Uptake, Metabolism, and Resolvin Biosynthesis from Docosapentaenoic Acid in Atlantic Salmon (Salmo Salar L.) Hepatocytes | Analytical Chemistry | ACS Publications share.google/73KyT9sn1NFVRsx…
Stable Isotope-Assisted Liquid Chromatography Mass Spectrometry Reveals Uptake, Metabolism, and...

Stable Isotope-Assisted Liquid Chromatography Mass Spectrometry Reveals Uptake, Metabolism, and...

Abstract. Docosapentaenoic acid (DPA, 22:5n-3) is an intermediate omega-3 polyunsaturated fatty acid with emerging biological significance, yet its metabol

pubs.acs.org
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Determination of the new psychoactive substances MDMB-4en-PINACA, ADB-BUTINACA and some of their metabolites in blood and urine using DLLE-LC-MS/MS: application to real forensic case samples - PubMed share.google/5BPoiyzUx9ERUJJ…
Determination of the new psychoactive substances MDMB-4en-PINACA, ADB-BUTINACA and some of their...

Determination of the new psychoactive substances MDMB-4en-PINACA, ADB-BUTINACA and some of their...

MDMB-4en-PINACA and ADB-BUTINACA are indazole-derived synthetic cannabinoids that have increasingly been encountered in forensic toxicology, partly due to their potent cannabinoid receptor activity...

pubmed.ncbi.nlm.nih.gov
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Derivatization Enhances LC-IM-MS of 11-Oxosteroids | LCGC International share.google/tVOQusZyMtW1kNu…
Derivatization Enhances LC-IM-MS of 11-Oxosteroids | LCGC International

Derivatization Enhances LC-IM-MS of 11-Oxosteroids | LCGC International

Christopher Chouinard of Clemson University discusses with LCGC International how derivatization reshapes steroid mass for sharper liquid chromatography-ion mobility-mass spectrometry (LC-IM-MS)...

chromatographyonline.com
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Development and Full Validation of a UPLC-MS/MS Method for the Simultaneous Quantification of Esketamine, Noresketamine, and Hydroxynoresketamine in Beagle Dog Plasma and Its Application to a Pharmacokinetic Study share.google/mjrAsBoZOHR0CwA…
Frontiers | Development and Full Validation of a UPLC-MS/MS Method for the Simultaneous Quantific...

Frontiers | Development and Full Validation of a UPLC-MS/MS Method for the Simultaneous Quantific...

Background: Esketamine (ESK) has garnered significant clinical interest as a rapid-acting antidepressant. Its pharmacokinetic profile is critically shaped by...

frontiersin.org
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Targeted analysis of purine derivatives in beer and fermented beverages using HPLC-QDA - ScienceDirect share.google/Olo1LHVVALaQJ5z…
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Development and Validation of a Stability‐Indicating UPLC‐PDA Method for Fruquintinib: LC‐QTOF‐MS/MS‐Based Structural Characterization of Degradation Products and <fi>In Silico</fi> ADMET Prediction - Nayak - 2026 share.google/TrCgXegRd9xnZLO…
Development and Validation of a Stability‐Indicating UPLC‐PDA Method for Fruquintinib: LC‐QTOF‐MS...

Development and Validation of a Stability‐Indicating UPLC‐PDA Method for Fruquintinib: LC‐QTOF‐MS...

Rationale Fruquintinib (FRQ) is a recently approved drug for the treatment of metastatic colorectal cancer. To date, only a limited number of studies have investigated the stability-indicating...

analyticalsciencejournals.onlinelibrary.wiley.com
79
Liquid chromatography-mass spectrometry approaches for analysis of polychlorinated alkanes: a review | Environmental Science and Pollution Research | share.google/yr4nHQjiuqhxmrj…
Liquid chromatography-mass spectrometry approaches for analysis of polychlorinated alkanes: a review

Liquid chromatography-mass spectrometry approaches for analysis of polychlorinated alkanes: a review

Environmental Science and Pollution Research - Polychlorinated alkanes (PCAs), the primary components of technical mixtures known as chlorinated paraffins (CPs), are complex and persistent...

link.springer.com
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Trace-Level Determination of Aflatoxins B1, B2, G1 and G2 in Peanuts and Raisins Using a Simplified QuEChERS–HPLC–FLD Method | South African Journal of Chemistry share.google/BpEhfUXWYTh7C3T…
Trace-Level Determination of Aflatoxins B1, B2, G1 and G2 in Peanuts and Raisins Using a Simplified...

Trace-Level Determination of Aflatoxins B1, B2, G1 and G2 in Peanuts and Raisins Using a Simplified...

Aflatoxins are highly toxic and carcinogenic mycotoxins that contaminate peanuts and dried fruits during storage. A simplified QuEChERS extraction, performed without dispersive solid-phase extraction...

journals.co.za
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New test method for determination of extractable per- and polyfluoroalkyl substances (PFAS) in consumer products by solvent extraction followed by liquid chromatography tandem mass spectrometry (LC–MS/MS) | Springer Nature Link share.google/abIbdSRnadI7OF4…
New test method for determination of extractable per- and polyfluoroalkyl substances (PFAS) in...

New test method for determination of extractable per- and polyfluoroalkyl substances (PFAS) in...

Environmental Monitoring and Assessment - Per- and polyfluoroalkyl substances (PFAS) are widely used in consumer products, raising health and environmental concerns due to their potential for...

link.springer.com
103
High-Sensitivity LC-MS/MS Method for Simultaneous Determination of Structurally Related Impurities 2-Isoniazid, 3-Isoniazid and Isonicotinamide in Isoniazid Active Pharmaceutical Ingredient - PubMed share.google/ko10rR02xNxJiSa…
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Advances in stability-indicating RP-HPLC for flavonoid analysis: transitioning from conventional to green analytical approaches | Journal of Inclusion Phenomena and Macrocyclic Chemistry | Springer Nature Link share.google/QtynrrziHmhZwsQ…
Advances in stability-indicating RP-HPLC for flavonoid analysis: transitioning from conventional to...

Advances in stability-indicating RP-HPLC for flavonoid analysis: transitioning from conventional to...

Journal of Inclusion Phenomena and Macrocyclic Chemistry - Flavonoids are important pharmacologically active phytoconstituents widely distributed in herbal extracts and are increasingly...

link.springer.com
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