Neuroscientist @DukeU, DNA enthusiast, admirer of the arts. Mom.
Durham, NC
Joined August 2014
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Excited to share our latest paper: implications for LRRK2 biology across clinically distinct neurodegenerative diseases pubmed.ncbi.nlm.nih.gov/4112…
The Fragile Future of American Science medschool.duke.edu/stories/f…
Please check out this interview discussing our findings.
Early Warning: New Blood Test Detects Parkinson’s ivanhoe.com/medical-breakthr…
So grateful to the @PFResearchTeam and rockstar @SilasABuck
📢 Congratulations to 2024 Postdoctoral Fellow, @SilasABuck, whose project focuses on LRRK2-HDAC6 pathway as a mediator of tau neurotoxicity in #Parkinsons disease. Dr. Buck is mentored by Dr. Laurie Sanders at @DukeU.
So lucky to be working with rockstar @sophia_lehrman3!
📢 Congratulations to 2024 Summer Student Fellow,
@sophia_lehrman3, whose project focuses on VPS35 and LRRK2 interplay underlying #Parkinsons Disease pathology. Sophia will be mentored by @LHSanders14 at @DukeU.
@ParkinsonDotOrg
Laurie Sanders retweeted
New paper from @LHSanders14 & her team (+ escape bio collab.s) reports that the #Parkinsons-associated LRRK2-G2019S mutant expressed at endogenous levels is sufficient to cause mtDNA damage in vitro; Both selective & non-selective LRRK2 inhibitors rescue
nature.com/articles/s41531-0…
Laurie Sanders retweeted
A #science conversation that is just fun to watch -
and really interesting that this #mtDNA damage marker seems specific to #parkinsons while being detectable in blood.
Great presentation by @LHSanders14 and moderation by @Dr_Behrouz
youtu.be/ge3PEDufp4o
Laurie Sanders retweeted
27 Questions - a lively Q&A session during Vincere Bio's weekly Journal Club.
@DukeU associate professor @LHSanders14 discussed her recent publication of a blood based Parkinson's disease biomarker, video below:
youtu.be/ge3PEDufp4o
Laurie Sanders retweeted
With the development of a blood test for damaged mitochondrial DNA, @duke_neurology's @lhsanders14 and team are finding new ways to diagnose Parkinson's disease early on, and hopefully identify treatments to reverse damage 🧬🩸 #DukeBrainInTheNews nih.gov/news-events/nih-rese…
Join FASEB for DNA Damage and Repair in the Brain on October 18. This informative FREE online conference on how DNA damage and dysfunctional DNA repair may contribute to neurodegenerative diseases. @LHSanders14
Reserve your spot: bit.ly/3POMyz8
So excited to share our efforts in developing a blood test for Parkinson's disease!
#Parkinsons @DukeHealth @DukeMedSchool
Science Translational Medicine
science.org/doi/full/10.1126…
So proud to have hosted an amazing DUNE scholar, read more about Iris' and other students experience here:
wunc.org/education/2023-08-2…
So excited to be working with this Stealth BioTherapeutics Team!
stealthbt.com/stealth-biothe…
Laurie Sanders retweeted
Our first paper of 2023 describes a method we developed to monitor DNA repair synthesis at high resolution- SAR-seq. We have applied this to study programmed DNA repair sites in neurons, repair synthesis during mitosis, and end-resection during homologous recombination.
Laurie Sanders retweeted
Are you planning to attend our Mitochondrial Dysfunction and Neurodegeneration 2023 meeting? We are welcoming abstract submissions until 20 February! Find out more and submit here: ow.ly/uNMf50LQSC0
ALT A Biochemical Society Scientific Meeting. Mitochondrial Dysfunction and Neurodegeneration. 20-21 April 2023, Nottingham, UK. Register online. Abstract and Earlybird deadline 20 February 2023.
Laurie Sanders retweeted
Anthony Fauci: A Message to the Next Generation of Scientists nytimes.com/2022/12/10/opini…
Laurie Sanders retweeted
New @biorxivpreprint manuscript from @LHSanders14 et al finds "levels of mtDNA damage may serve as a potential pharmacodynamic biomarker of altered kinase activity that could be useful" for clinical development of #Parkinsons-associated LRRK2 inhibitors
biorxiv.org/content/10.1101/…
Check out our latest preprint on the utility of our mitochondrial biomarker and precision medicine based LRRK2 therapeutics for Parkinson's disease.
doi.org/10.1101/2022.11.30.5…
Laurie Sanders retweeted
Join us for Mitochondrial Dysfunction and Neurodegeneration 2023! We are bringing together leading academic researchers in #Mitochondrial research to initiate further collaborations. Register now for Earlybird discount: ow.ly/uvXB50LuhE7
ALT A Biochemical Society Scientific Meeting. Mitochondrial Dysfunction and Neurodegeneration. 20-21 April 2023, Nottingham, UK. Register online. Abstract and Earlybird deadline: 20 February 2023.