Research group at the University of Cologne
Joined July 2020
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Hofmann_Lab retweeted
Proud to share The E3-ome
A true collaborative effort to unify the human E3 ligase landscape, and create a shared foundation for the field
#Ubiquitin #E3Ligases @WEHI_research
cell.com/cell/fulltext/S0092…
I am deeply saddened learning that my scientific hero Amos Bairoch has recently passed away. He will be remembered as the mastermind behind the SwissProt and many other endeavours in protein bioinformatics. There is a tribute web page at sib.swiss/amos/
For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. biorxiv.org/content/10.64898…
Very interesting finding from the Escobar group next door, with some minor contributions from us.
Online Now: Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity dlvr.it/TNFK9q
Hofmann_Lab retweeted
Measure protein deamidation by bacterial secreted proteins? Check out the recent NMR paper. Congratulations to @Rashmi_Agrata
doi.org/10.1002/mrc.70045
Hofmann_Lab retweeted
New Parkinson’s disease paper:
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of USP30 and a framework for DUB ligandability - published by @MalteGersch group @maxplanckpress in @Nature Struct. & Mol. Biol.
nature.com/articles/s41594-0…
Hofmann_Lab retweeted
Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s41594-0…