We use brain organoid and chimeric-brain platforms to uncover disease mechanisms and engineer human microglia for brain repair.
Piscataway, NJ 08854
Joined February 2020
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Thrilled to share our review just published in @NeuroCellPress!
Big shoutout to Ava, Mengmeng , and our entire team!
authors.elsevier.com/a/1k-uh…
Human brain cellular xenografts in neuroimmunology and beyond: Immunity cell.com/immunity/fulltext/S…
Peng Jiang Lab retweeted
A cross-species AAV platform for precise microglial interrogation: @NeuroCellPress cell.com/neuron/fulltext/S08…
Peng Jiang Lab retweeted
🎉New in Neuron! We identified that microglia-derived soluble DLK1 links aging to hypomyelination. In mouse and human iPSC models, telomere shortening drives microglial senescence, ↑sDLK1, and impaired oligodendrocyte maturation and neuronal activity. cell.com/neuron/fulltext/S08…
Peng Jiang Lab retweeted
From @Nature : The aging human brain is more dynamic than we thought. Somatic mutations revealed marrow-derived cells in every human brain studied, sometimes forming a large share of microglia, Clonal hematopoiesis was also linked to a lower risk of AD. nature.com/articles/s41586-0…
Peng Jiang Lab retweeted
Beautiful study lead by Julia, Howard, Siddhartha and co. follows the ontogeny of microglia in human aging
nature.com/articles/s41586-0…
A truly groundbreaking study showcasing the transformative potential of human glial chimeric brain models for in vivo AAV evolution. Combining human glia-selective capsids with glymphatic delivery represents a landmark advance toward precise CNS gene therapy!
Efficient targeting of human glial progenitor cells in vivo with engineered AAV vectors and glymphatic delivery nature.com/articles/s41587-0…
Well said on the role of somatic mutations in myeloid cells in Alzheimer's disease! (cell.com/trends/molecular-me…)
The CSF2RB A455D variant from our study is also a promising example. More studies using chimeric brain models with human microglia carrying somatic mutations are needed.
Can grafted microglia be harnessed for neuronal replacement?
Motivated by their unique properties for cell-based therapies, we explored the direct conversion of human microglia into neurons. Excited to share our new study on bioRxiv.
Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains biorxiv.org/content/10.64898…
All models have limitations. Animal models are indispensable for neuroscience research. Meanwhile, chimeric brain models provide opportunities to study human neural cells with advanced maturation and functional integration in an in vivo brain environment
cell.com/cell-metabolism/ful…
Chimeric brain models: Unlocking insights into human neural development, aging, diseases, and cell therapies: Neuron cell.com/neuron/fulltext/S08…
Aβ plaques induce local pre-synaptic toxicity in human iPSC-derived ne... sciencedirect.com/science/ar…
Thrilled to share our new study published in @CellReports! 🎉
Led by @jin_mengmeng, @ZiyuanMa5, and Haiwei Zhang. Grateful for a wonderful collaboration with Dr. Steve Goldman, a pioneer in chimeric brain models and glial biology.
cell.com/cell-reports/fullte…
Thank you for highlighting our work!
New study from Jiang group gives clues to Down syndrome patients' resilience to AD: DS-linked myeloid mutation CSF2RB A455D protects engrafted human microglia against tau by suppressing IFN signaling, boosting phagocytosis, & reducing microglial senescence nature.com/articles/s41593-0…
Peng Jiang Lab retweeted
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease @NatureNeuro
nature.com/articles/s41593-0…
An idea we started in 2019 is now published in @NatureNeuro! Excited to share our new study: rdcu.be/eRvdA
Congrats to Mengmeng Jin @jin_mengmeng and our team! Heartfelt thanks to all collaborators for their support, and to the reviewers for their insightful comments!
Explore our new study here 👇, and Happy Thanksgiving to all!
Author’s link: rdcu.be/eRvdA
Rutgers Today article @RutgersU_News @RutgersSAS @RutgersU:
rutgers.edu/news/inspired-fa…