Developmental and stem cell biology lab. Understanding the control of cell identity and plasticity and how to use it in regenerative medecine @KCLstemcells
London, UK @[email protected]
Joined May 2019
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So excited to share our new paper today @Nature
Truly interdisciplinary study: #computational modelling, #lineagetracing and #scRNASeq uncovers sustained plasticity in hepato-pancreato-biliary development (1/2)
disq.us/t/40i2bhl
@LabSpagnoli @KCLstemcells @kingsmedicine
Spagnoli Lab retweeted
Our SEPTEMBER ISSUE is live! Pancreatic development, γδ T cells in CRC and liver cancer, precision nutrition in IBD, SLD in Latin America, and much more!
nature.com/nrgastro/volumes/…
ALT COVER: Pancreatic development, inspired by the Review starting on p674.
Spagnoli Lab retweeted
PhD opportunity in Aging, Bioengineering & Regenerative Medicine 🧬
We are recruiting for a fully funded 3-year PhD position in beautiful Lausanne, Switzerland 🇨🇭
Applications will be reviewed ONLY through the official UNIL website: sl1nk.com/f8ejy4l
Spagnoli Lab retweeted
📣 One week left to register for #HumanDev26.
We have teamed up with the @wellcometrust -funded consortium Human Developmental Biology Initiative (HDBI) to co-organise our 2026 Journal Meeting. Register by 24 July 2026. biologists.com/meetings/devh….
ALT Promotional banner for the ‘Human Development: Stem Cells, Models, Embryos’ meeting, taking place 7–9 September 2026 at the University of Warwick, UK. The left side features white text on a black background with a blue box stating ‘Register now. Final deadline: 24 July 2026.’ Logos for Development and the Human Developmental Biology Initiative appear below. On the right is a colourful, spherical, microscopy-style image of a cellular structure. The hashtag #HumanDev26 appears at the bottom right.
Spagnoli Lab retweeted
Our Section is recruiting an Assistant Professor, have a look at the link and apply if you'd like to be our new colleague! lnkd.in/dfEspZuF
Spagnoli Lab retweeted
Congratulations to Professor Francesca Spagnoli from King's College London who has been elected as a member of EMBO – recognising her outstanding contributions to life sciences research.
Read more: kcl.ac.uk/news/professor-fra…
Spagnoli Lab retweeted
📣 New PRBB-CRG conference
📋 Mapping progenitor niche dynamics for regulation of cell fate
🗣️ Francesca Spagnoli (@LabSpagnoli) - @KCLstemcells
📆 May 22 - ⏰ 12:00
hosted by: @1jorgeferrer - @CRGenomica
📍 #PRBB Maria Skłodowska-Curie room
🎇Great fun writing this #review with
#AlejoTorresCano, highly talented postdoc in @LabSpagnoli
🤔reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity
@wellcometrust @kingsmedicine @BreakthroughT1D @DUK_research
New online! Understanding development and cellular plasticity in the pancreas in health and disease dlvr.it/TSXJ51
Spagnoli Lab retweeted
Drs. Alejo Torres-Cano (@LabSpagnoli) and Francesca Spagnoli explore how cellular plasticity and microenvironmental interactions drive #PancreaticDevelopment, regeneration, and disease, with implications for therapies for diabetes and pancreatic cancer.
Read the #review in @NatRevGastroHep: go.nature.com/4fjnL3m
Spagnoli Lab retweeted
🎉 Very happy to have had the opportunity to contribute to this latest @DiseasePrimers #Review on #PancreaticCancer together with a number of great colleagues! @ednacukierman @EileenMOReilly @SaurLab @BarbaraGrnwald ...
Hope it is a useful read! 😊💜
nature.com/articles/s41572-0…
Spagnoli Lab retweeted
My department at Oxford is recruiting junior faculty to the Ludwig Institute for Cancer Research. A collaborative and stimulating department, with great access to the breadth of the Oxford environment. The positions come with core funding and cutting edge technologies. If interested, apply here: shorturl.at/1ggGt
Spagnoli Lab retweeted
Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids biorxiv.org/content/10.64898… #biorxiv_devbio
Spagnoli Lab retweeted
New research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬
kcl.ac.uk/news/research-reve…
Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791
🚨 here it is the #DashBoard accompanying our new paper (see 🧵 below)
➡️ spatial-pancreatic-maps.site…
😃 have fun exploring the dataset & #spatial #maps 🗺️
👏 👏 Kudo to Sami (#SiwanartaMa) MSc Bioinformatics for building the #DashBoard !!
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations
Alejo Torres-Cano, who led the study
+ past & current team @LabSpagnoli
+ collaborators #VigilanteLab
@kingsmedicine
➡️ doi.org/10.1126/scia...
Spatially organized cellular communities shape functional tissue architecture in the pancreas | Science Advances science.org/doi/10.1126/scia…
Congrats Alejo Torres-Cano postdoc in the @LabSpagnoli @KCLstemcells
🕰️ Alejo Torres-Cano and team at @KingsCollegeLon combine single-cell and spatial transcriptomics to map pancreatic cell populations across space and time, from embryonic development to adult homeostasis in mice.
@ScienceAdvances | bit.ly/4pcQAQR
🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations
Alejo Torres-Cano, who led the study
+ past & current team @LabSpagnoli
+ collaborators #VigilanteLab
@kingsmedicine
➡️ doi.org/10.1126/scia...
We built ‘maps’ 💻showing that pancreatic progenitors and nearby supporting cells form niches &
used #stemcells 🧫to recreate pancreatic niches in the lab 🧪 & study how human beta cells develop
🙏 the Editor #ScienceAdvances & reviewers for great insights and comments
🙏🙏 all our fundings @EUCouncil @wellcometrust
@NC3Rs #FundaciónAlfonsoMartínEscudero #postdoc support
@KCLBMBioscience
@BT1DUK #T1DGrandChallenge @DiabetesUK for next step of these discoveries
