γδ T cell immunology lab of Professor Ben Willcox at @ImmunologyUoB at the University of Birmingham @unibirmingham
Birmingham, England
Joined May 2019
- Tweets283
- Following199
- Followers741
- Likes694
Very excited to share our study in @CellReports on the transcriptional basis of peripheral blood Vδ1+ T cell adaptive differentiation. cell.com/cell-reports/fullte…
Looking forward to the @BSI_TumourImm Tumour Microenvironment meeting in Birmingham today and tomorrow. Hope to catch up with old friends and colleagues there and hear about some exciting new science!
Willcox LAB retweeted
Want to get up to speed with immune checkpoint blockade therapy for cancer ?
Register now for this online 13-hour CPD course ‘Understanding immune checkpoint blockade therapy: a pillar of modern cancer treatment’, from the University of Birmingham, UK, starting on Jan 24th, 2024.
Pleased to be involved in this tour de force from @MohindarMK and the Herrmann lab!
I am happy to share our recent article at @NatureComms, presenting intricate mechanistic details on antigen - BTN interaction and BTN domains required for optimal Vg9Vd2 T cell activation. rdcu.be/drQzF
@LabWillcox
@WillcoxCarrie
@forum_gd
@Uni_WUE
9
520
Thoroughly enjoyed our @ImmunologyUoB Away Day today. Fantastic posters and presentations by all including our very own @JulietGunn and PhD student Charlotte Begley, who won a prize for her work on splenic γδ T cells!
Willcox LAB retweeted
Pleasure to write a meeting report on the 10th International Gamma-Delta T Cell Conference with @JuRiLibot @eberlmat @LabWillcox @ErinJAdams for @NatImmunol :)
It can be read here:
rdcu.be/dmYbc
Willcox LAB retweeted
We have a post-doc position available focused on intestinal and cancer immunology. Ideal for PhD students soon to submit, who want to work with some cool in vivo models to better understand immune responses. Position advertised on BSI Jobs Board
immunology.org/careers/bsi-j…
Congrats to @MohindarMK for winning best presentation in the Ligands and Repertoires session!
1
7
166
We’ve had a fabulous time at #gd2023! Thank you to @BSilva_Santos and Julie Ribot and team for putting on such a superb meeting. Enjoyed the science and catching up with friends and collaborators.
Last few days to apply for a senior research technician job in our group! Join the team working on the best cells! jobs.ac.uk/job/CYY523/senior…
Willcox LAB retweeted
Phosphoantigen sensing combines TCR-dependent recognition of the BTN3A IgV domain and germline interaction with BTN2A1 dlvr.it/SlgNLv
Congratulations to @WillcoxCarrie and all collaborators not on Twitter. Link to Hermann lab study assets.researchsquare.com/fi…
3
205
Willcox LAB retweeted
New study on BTN3A1/BTN2A1/Vγ9Vδ2 TCR interactions out now in Cell Reports! @forum_gd We use mutagenesis, NMR and modelling to probe BTN2A1/3A1 IgV interactions. In a cool NMR expt we show that BTN2A1 IgV domain cannot bind simultaneously to BTN3A1 and TCR cell.com/cell-reports/fullte…
Our study complements a recent preprint by our collaborators in the Hermann lab showing a division of labour between BTN3A molecules in pAg recognition. Also interesting data coming soon from Zhang and Uldrich labs.
1
1
244
Bearing in mind Wiemer lab data that show pAg induces interaction of 3A1 and 2A1 B30.2 domains, we favour a composite ligand model whereby pAg spatially coordinates weak, separate TCR interactions with 2A1 and 3A1 to surpass a threshold for TCR triggering.
1
2
139