What happens when osimertinib stops working? A major concern for our EGFR+ #lungcancer community. SAFFRON Phase III: 17.8 vs 12.9 months median survival with osimertinib + savolitinib vs chemotherapy in MET-altered disease. Promising results #ESMO2026. Now, what about UK access? nejm.org/doi/full/10.1056/NE… #LCSM

Update: AstraZeneca announced this morning that sunvozertinib is now available in the United States. A major win for the lung cancer community, especially patients with EGFR exon 20 insertion lung cancer who have been waiting for this option. China approved it in August 2023. The FDA approved it in July 2025. It became commercially available here today. More than three years from its first approval to US availability. I did not expect this many people to read about my mom. Thank you. If you or someone you love is going through this and doesn’t know where to turn, my messages are open. astrazeneca-us.com/content/a…

In January 2025 my mom’s lung cancer spread to her brain. The drug with the best chance of helping her was approved in China but not here. A doctor told me, almost as an aside, that if she were Chinese she could buy it at a pharmacy. So I flew to Shanghai and came home with 26 boxes in my luggage. That was 19 months ago. My mom is still here, still working, and in her words has had an amazing three years. The drug was approved in China in 2023. The FDA approved it in July 2025. It still is not for sale here. I know of at least 30 Americans who have made the same trip. I have been scared to tell this story because I worried it could cost my mom access to the medicine keeping her alive. But the problem matters more than my silence. These drugs need to be developed and available here, and that means FDA reform. Art Allen at KFF Health News told our story this week. It also ran in The Washington Post. kffhealthnews.org/health-ind…

#Sunvozertinib is now available! Thank you, @AstraZeneca and @AstraZenecaUS —-For those #EGFR exon 20 insertion patients who have just progressed on ami plus chemo, please talk to your medical oncologist about sunvozertinib and double check with your medical center’s pharmacy services department in case of a delay in ordering or receiving #sunvo. Hooray—many thanks from @Exon20Group ! #LCSM

Today we lost Kelsey..a beautiful soul & beloved member of our lung cancer community. She leaves behind her husband and four boys. This disease continues to shatter families & break our hearts every day. Please take a moment to read her story: gofundme.com/f/support-kelse…

Phase II ETOP 18-21 AMAZE-lung trial of 2L amivantamab + lazertinib + bevacizumab after 3G TKI in EGFR NSCLC @LancetRespirMed. RR 39%. TRAEs included infusion reaction 58%, rash 50%, VTE 17% which would likely be mitigated with SQ and modern support. thelancet.com/journals/lanre…

Pope Leo XIV @ Pontifex being diagnosed with lung cancer as a never smoker is not as rare as you may think. The CDC estimates that 10–20% of lung cancers in the U.S. occur in never-smokers. We have been talking about this trend for a while. Read more here 👇 🔗 news.umiamihealth.org/en/non…

BIG NEWS FOR LUNG CANCER SCREENING: Governor Gavin Newsom has officially signed California SB 1124 into law! 🫁🎉 What began as a bill written by our incredible team on a word document is now California law!!!!! SB 1124 will require tobacco retailers across California to display signage about #lungcancerscreening, bringing information about lifesaving #earlydetection directly to individuals who are most likely to benefit. This milestone would not have been possible without the extraordinary team behind this effort. HUGE congratulations to @ucla_alcsi students Miah Chao, Elaine Dong, Ethan Chen whose tenacious advocacy, leadership, and coalition-building over the past 2 years are the reason this bill passed today. Congratulations as well to Deepti Srinivasan (@deeptisrini), Alex Potter (@alexandra_p_24), Phoebe Lee, and Dr. Chi-Fu Jeffrey Yang (@ChiFuJeffYang) for coming up with the vision to require signs about lung cancer screening wherever tobacco is sold and for drafting this innovative bill 3 years ago. We are also deeply grateful to Senator Bob Archuleta for championing SB 1124, and to the lung cancer survivors, advocacy organizations, physicians, students, and community leaders who made this bill possible. We are incredibly inspired by the momentum behind this legislation and the opportunity it creates to shine a light on lung cancer screening and early detection. And we hope this is only the beginning! California has created a model that we hope to bring to states across the country, and we can’t wait to build on this progress! 🤍