@LeDouxScience

A behavioral neuroscience lab dedicated to understanding the ways in which the brain forms, stores and retrieves memories about threatening events.

 New York, New York
cns.nyu.edu/ledoux
Joined May 2013
  • Tweets837
  • Following952
  • Followers3.4K
149Media
New paper: "Induction of conditioned #avoidance via mental #imagery". New article available at Behaviour Research and Therapy, with @G_Mertens, Leer, & Engelhard! (sciencedirect.com/science/ar…)
2
3
20
"defensive responses like fleeing or freezing can co-occur with feelings of fear, not because the neural processes underlying these two kinds of events are intimately entwined in the amygdala, but instead because the events have the same starting point." Completely agree!
Joseph E. LeDoux "The Four Realms of Existence"@theamygdaloid8 Jun 2020
"Thoughtful Feelings" is a new My Word article in Current Biology. It's an overview of my ideas about what emotions are. Thank you @GeoffreyNorth1 for publishing these "thought pieces." authors.elsevier.com/a/1bCM7…
1
1
8
Did you ever wonder what happens to memory in Alzheimer's disease? We found that the memory trace is still there, but impaired by interference with other neuronal ensembles. Like a noisy radio channel. Check it out: nature.com/articles/s41593-0… @DZNE_en @DZNE_de

Memory trace interference impairs recall in a mouse model of Alzheimer’s disease

Nature Neuroscience - Mice with AD-like pathology and memory impairments surprisingly have memory engrams in their hippocampus. However, interference with novelty-like cells prevents proper recall,...

nature.com
8
65
7
186
"Thoughtful Feelings" is a new My Word article in Current Biology. It's an overview of my ideas about what emotions are. Thank you @GeoffreyNorth1 for publishing these "thought pieces." authors.elsevier.com/a/1bCM7…
5
41
7
91
Great talk by @hakwanlau at Consciousness Club @WCHN_UCL dealing with which creatures are conscious and ending with suggested clinical treatments for fear and phobia. Thanks to @smfleming for organizing – at Islington, London
3
4
1
27
New preprint from our lab! On our quest to understand how neural activity drives behavior we made a big step forward. Find how we quantify and map DeepLabCut annotated behavior using Deep Variational Autoencoders. VAME GitHub Toolbox available. biorxiv.org/content/10.1101/…

Identifying Behavioral Structure from Deep Variational Embeddings of Animal Motion

Naturalistic behavior is highly complex and dynamic. Approaches aiming at understanding how neuronal ensembles generate behavior require robust behavioral quantification in order to correlate the...

biorxiv.org
8
52
8
145
New preprint from the lab on how the retrosplenial cortex and the superior colliculus help mice find their way home when they are scared. Led by the fantastic duo @RubenDVale and Dario Campagner. #gimmeshelter biorxiv.org/content/10.1101/…

A cortico-collicular circuit for accurate orientation to shelter during escape

When faced with predatorial threats, escaping towards shelter is an adaptive action that offers long-term protection against the attacker. From crustaceans to mammals, animals rely on knowledge of...

biorxiv.org
5
46
8
144
LeDoux Lab retweeted
Wei Ji Ma@weijima014 May 2020
Confused about confidence? Bored with Bayes? Tired of 2-AFC? Join us for a virtual journal club: Monday May 4th at 12:30 New York time on nyu.zoom.us/j/99274459619 @hsinhungli and I will present our paper on multi-alternative confidence nature.com/articles/s41467-0…
2
10
47
It's finally out! Congratulations @ArminLak. The paper is here: sciencedirect.com/science/ar… (and it *will* be Open Access -- working on it right now)
Armin Lak@ArminLak18 Dec 2019
Our work is published today at @NeuroCellPress. With @michael_okun, @morganemoss, @HarshaGurnani, @KarolinaFarrel, Miles Wells, @charureddy, @KepecsLab, @kennethd_harris, and @MatteoCarandini
1
8
39
New preprint from @candelabellot in @MacAskillAF lab @uclnpp! Push-pull regulation of exploratory behavior by two opposing hippocampal to prefrontal cortex pathways biorxiv.org/content/10.1101/…

Push-pull regulation of exploratory behavior by two opposing hippocampal to prefrontal cortex...

We found that the hippocampal projection to prefrontal cortex is composed of two parallel circuits located in the superficial or deep hippocampal pyramidal layers. These circuits have unique upstream...

biorxiv.org
3
1
7
Excited to share a preprint of the final work from my postdoc lab where we show that prelimbic cortex bidirectionally controls platform-mediated active avoidance. @jorgeiravedra @rojasbowe @JonathanMoranPR @vpvalentin_ biorxiv.org/content/10.1101/…

Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance

The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance, the PFC likely plays a role in selecting the optimal...

biorxiv.org
2
14
5
38
#BRAINInitiative virtual event in 1.5 hr on "How Can Dynamical Systems Neuroscience Reciprocally Advance Machine Learning" #machinelearning events.labroots.com/event/BR… featuring @rajankdr @KordingLab @xaqlab @nathanieldaw
3
10
2
27
LeDoux Lab retweeted
BryanRoth
@zenbrainest4 Jun 2020
Looking forward to speaking @StanfordBrain today at 12 PM pacific on "New technologies for neuroscientists (and others" neuroscience.stanford.edu/ev…
3
3
14
LeDoux Lab retweeted
Adam Carter@CarterAG13 Mar 2020
Our new study with @GordFishell and @JDimidschstein is now on bioRxiv, showing how the ventral hippocampus engages CCK+ interneurons in the prefrontal cortex, with endocannabinoid modulation of inhibition at only a subset of L5 pyramidal cells: @theXL92 biorxiv.org/content/10.1101/…

Hippocampal inputs engage CCK+ interneurons to mediate endocannabinoid-modulated feed-forward...

Connections from the ventral hippocampus (vHPC) to the prefrontal cortex (PFC) regulate cognition, emotion and memory. These functions are also tightly regulated by inhibitory networks in the PFC,...

biorxiv.org
17
3
39
LeDoux Lab retweeted
Simon Peron@PeronLab18 Apr 2020
Congrats @TinaVoelcker! This is one of those really pretty results I think a lot of folks suspected was true but never confirmed. Until now.
Alex Naka@gottapatchemall18 Apr 2020
Two dynamically distinct circuits driving inhibition in sensory thalamus biorxiv.org/content/10.1101/…
2
11
Excited to present new results in the #BRAINInitiative Investigators Meeting virtually today at 11:30 am ET. 🧠💫 You can register for the event here: events.labroots.com/event/BR… or follow the #StudyBRAIN hashtag!
4
10
1
57
Congratulations Moita Lab @Neuro_CF @ChampalimaudF !
PLOS Biology@PLOSBiology13 May 2020
Sshh... That sudden sound of silence... When others stop and silence ensues, animals respond as if threatened. Study from @Neuro_CF identifies the brain areas involved in listening to dangerous silence (thalamus, auditory cortex, amygdala) #PLOSBiology plos.io/3fLDYNu
8
1
24
Lateral #thalamus neurons that express calretinin provide integrated CS–US representations to the lateral #amygdala (LA) that support the formation of aversive memories in mice go.nature.com/2xkk6jq
2
24
1
64
Brought to you from Buzsaki Lab Bay F - a review! Wherein @dlevenstein, @kmcclain340, @davidwtingley, @brainrhythms, and I chew on what we really mean when we say (re)activation. Thank you to @morganbarense @hugospiers for organizing such a cool issue. authors.elsevier.com/c/1aqv7…
6
29
2
102
When I first started studying rodents in 1980s there was strong anti-rodent sentiment because it was necessary to over-value primate research to project the investment. Now the rodent work is falsely touted as the answer. Both have limits and advantages. Best to know both.
hakwan lau 🇺🇦 @hakwan.bsky.social@hakwanlau8 Apr 2020
it has suddenly dawn on me why certain authors have been writing off the role of the PFC in any kind of perception / sensation / motor intention etc, despite the mountain evidence.
1
6
38
Load more