🎧 Exciting new discovery from @li_lingyin and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling headphones for the cGAS-STING pathway. cGAS-STING is a crucial immune defense mechanism for the human body that’s triggered in response to threats like viral and bacterial infections and cancer. But how does it know when to fight and when to stand down? Lingyin and Chris found that PELI2 acts like a sensor, filtering out cellular “white noise” that could chronically trigger STING—and lead to inflammatory conditions like lupus and neurodegeneration. At the same time, PELI2 turns into an amplifier when interferon levels grow above a certain threshold, ensuring that STING turns on at the right time.

⚡After discovering the role of the ENPP1 enzyme in masking cancer from the immune system, @Lingyin_Lab has found a new enzyme, ENPP3, that also inhibits cGAMP-STING signal + anti-tumor immune response, preventing immunotherapies like Keytruda from working effectively. 🧵⬇️

It is a great honor to participate in Cell Chemical biology’s special issue focusing on Inflammasomes and Immunoregulation to celebrate the 30th anniversary of the journal in 2024. Also celebrating 10 years of ENPP1 and extracellular cGAMP. authors.elsevier.com/a/1j357…

Breast cancer is 1 of the deadliest cancers for women, but <20% respond well to immunotherapy. New research in @PNAS from Arc Investigator and @Stanford Biochem Prof @li_lingyin + @Stanford grad student Songnan Wang uncovers why. bit.ly/48q50EN 🧵

My former account was compromised. If you find me here somehow, please add me back to your circle. This article proves that this is the real Lingyin Li and I am not trying to sell you crypto. If you still do not believe me, AMA about STING and cGAMP. biorxiv.org/content/10.1101/…