@LolleSigne

Utilizing droplet co-cultivation of archaeal-bacterial consortia, attempting to reenact eukaryogenesis and to look deeper into cross-domain interactions.

 Copenhagen, Denmark
Joined December 2018
  • Tweets75
  • Following110
  • Followers124
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A quick and easy reading of our latest work, written by @PabloLaborda95 and illustrated by Elena Contel Maza. Behind the paper: "Mutations in the efflux pump regulator MexZ shift tissue colonization by P. aeruginosa to a state of antibiotic tolerance". communities.springernature.c…

Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to...

Mutations in the efflux pump regulator encoding gene mexZ, one of the most frequently mutated genes in Pseudomonas aeruginosa during early chronic respiratory infection, render this pathogen more...

communities.springernature.com
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Take a look at the @NatureComms 'Behind the Paper' post of our manuscript! And check out its amazing heading illustration made by Elena (@ helen.mushu.science on Instagram) 🦠🧫 communities.springernature.c…
Pablo Laborda@PabloLaborda9522 Mar 2024
The final version of our manuscript is out in @NatureComms!🤩 Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to a state of antibiotic tolerance @besaraornottobe @LolleSigne @Rigshospitalet @DTUBiosustain 🧵👇nature.com/articles/s41467-0…

Mutations in the efflux pump regulator MexZ shift tissue colonization by Pseudomonas aeruginosa to...

Nature Communications - Mutations in mexZ, encoding a negative regulator of efflux pump genes, are frequently acquired by Pseudomonas aeruginosa during early lung infection, but do not confer high...

nature.com
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The first work of my postdoc at @Rigshospitalet and @DTUBiosustain is now available as a preprint! 🤩 Here we show that some antibiotic resistance mutations have hitherto unknown consequences that transcend conventional antibiotic resistance perspectives during infection
bioRxiv Microbiology@biorxiv_micrbio21 Aug 2023
Efflux pump mutations in Pseudomonas aeruginosa cause low-level clinical resistance and high-level tolerance to antibiotics in patients biorxiv.org/cgi/content/shor… #biorxiv_micrbio
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Excited to have this paper published! Here we looked at single-cell responses to virulent Pseudomonas within a leaf, followed by spatial investigation. Collab with @colepbio @LolleSigne @KvitkoPhD and heavy lifting by Jie Zhu. cell.com/cell-reports/fullte…

Single-cell profiling of Arabidopsis leaves to Pseudomonas syringae infection

Zhu et al. report the plant response to Pseudomonas infection at single-cell resolution, showing that leaves exhibit cell populations at opposing states (immune and susceptible). Immune and suscept...

cell.com
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Our group leader Prof. Helle K. Johansen giving a fantastic talk about the effect of #CFTR #modulators in Denmark hospitals. A really nice study performed by PhD student Maria Bendixen and data analyst Oihane Irazoqui. #ECFS2023 #pathogens #microbiology – at Vienna, Austria
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Thank you @mcmicrobes for the nicely written News & Views over our latest citrus immunity paper. What a nice surprise!
Plant Physiology@PlantPhys25 May 2023
NEWS & VIEWS: New receptors for common MAMPs: Can wild relatives save citrus from disease? buff.ly/45v9ARi @ASPB #PlantSci
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Are you interested in host-microbe interactions and in the role of the immune system during an infection? Our group at @Rigshospitalet and @DTUBiosustain is looking for a PhD student to join our very exiting projects! candidate.hr-manager.net/App… Please RT.
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Excited to have this work out on single-cell analyses of plant-bacterial interactions within a leaf, which led to spatial/temporal discoveries. Collab with @colepbio ⁦@LolleSigne⁩ ⁦@KvitkoPhD⁩ and heavy lifting by Jie Zhu biorxiv.org/content/10.1101/…

Single-cell profiling of complex plant responses to Pseudomonas syringae infection

Plant response to pathogen infection varies within a leaf, yet this heterogeneity is not well resolved. We exposed Arabidopsis to Pseudomonas syringae or mock treatment and profiled >11,000 individ...

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Signe Lolle retweeted
Pedromics@pedromics22 Apr 2022
Neutrophil. Neutrophil. Does whatever a neutrophil can.
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Excited to announce that I will be chairing the next #Pseudomonas #conference in beautiful #Copenhagen 🇩🇰 I look forward to work w/the global Pseudomonas research community to keep the high scientific level of this meeting series—that started in 1986, organized by @KennethTimmis!
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Pls RT - exciting #postdoc position available in our lab @DTUBiosustain. This interdisciplinary project bit.ly/360cMYh will unite yeast #synbio #neuroethology and #decisionmaking to model/predict #insect behavior w/ @SilkeSachse @MPI_CE & @GTheraulaz @CbiToulouse + you?
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Early Career Plant biologists, Present your work @GordonConf GRS Plant Molecular Biology "Emerging Approaches for Understanding and Engineering Plants" Deadline: March 13, 2020 Chairs: Jennifer Brophy & Signe Lolle @LolleSigne grc.org/plant-molecular-biol… @MC_Lab_PlantBio @rm0sher
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MAMPs, PTI, NLRs, NTI, acronym-oh my! New to NLR-immunity or plant immunity? Or want a quick review? Come check out our minireview! authors.elsevier.com/c/1aQ7D… @LolleSigne @GittaCoaker @UCDPlantPath @UCDavisGenetics
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Signe Lolle retweeted
Brian Kvitko@KvitkoPhD18 Jun 2019
Hey all you plant and microbe tweeps! We're hiring a Postdoc! We're looking for someone comfortable with bacterial genetics and molecular biology to study how plant immunity interacts with the AlgU/RpoE pathway. Early 2020 start date More details here. site.caes.uga.edu/kvitkolab/ – at Georgia, USA
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