Mattia Privitera (@MattiaPri) header
Mattia Privitera (@MattiaPri) profile picture

Neuroscience. Locus Coeruleus and Noradrenaline.

Zurich, Switzerland
Joined June 2018
Photo by Mattia Privitera (@MattiaPri)Photo by Mattia Privitera (@MattiaPri)Photo by Mattia Privitera (@MattiaPri)Photo by Mattia Privitera (@MattiaPri)Photo by Mattia Privitera (@MattiaPri)
During moderate tonic locus coeruleus activation in mice, noradrenaline release engages cortical regions related to associative processing, while burst-like stimulation biases the brain toward sensory processing nature.com/articles/s41593-0…
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Mattia Privitera retweeted
Out now in @NatureNeuro: "Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus", nature.com/articles/s41593-0… With a great team: @FritjofHelmchen @BohacekLab @SianDuss @cloois and (twitterless) Denise Becker. 1/5
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Mattia Privitera retweeted
🔵 Noradrenaline directly regulates gene expression in the brain. 8 years in the making, now finally published in @eLife 🥳 During revisions, we added 32 RNAseq samples and a meta-analysis of 71 RNAseqs to rule out major sex differences. #stress Please RT elifesciences.org/articles/8…
🚨🔵🚨 Our work on stress-induced gene expression changes mediated by #LocusCoeruleus #noradrenaline has now been reviewed by @eLife !🥳🤩 We got constructive and positive feedback 🙏, and we're tackling those pesky sex effects once more #revisions elifesciences.org/reviewed-p…
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The first cellular map of a mammalian brain is here. 🧠✨ Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals astonishing diversity and regional specificity. Dive deeper: alleninstitute.org/scientist… @nature #studyBRAIN #BICCN
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A new review paper led by @mj_dahl, Agnieszka Kulesza and @WB_Markus. We review how deficient #dopaminergic and #noradrenergic modulation of hippocampal plasticity may contribute to memory loss in aging and Alzheimer's disease sciencedirect.com/science/ar… #locuscoeruleus
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That's all folks! You gave me everything. I gave you everything. We did it together.
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🚨In our latest preprint🚨 we propose a radical change to the analysis of rodent #behavior in preclinical research. Featuring @DeepLabCut ♥️ Check out the manuscript and the 🧵👇 nitter.gq/biorxiv_neursci/status…
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Mattia Privitera retweeted
🔵 In 2016 I wrote a grant, in which @MattiaPri and I asked a simple question: Stress triggers massive transcriptional changes, which of them are dependent on noradrenaline (NA) signaling? Today, we have the answer. But boy was this a journey. 🧵👇 biorxiv.org/content/10.1101/…
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New Nature paper provides evidence that science has become less innovative since the 1950s. The authors suggest reversing the trend by: 1. reading widely, 2. focusing less on quantity of papers, & more on research quality, 3. taking year-long sabbaticals. nature.com/articles/s41586-0…
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The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics biorxiv.org/cgi/content/shor… #biorxiv_neursci
The locus coeruleus mediates behavioral flexibility biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Locus Coeruleus firing patterns selectively modulate brain activity and dynamics biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Mattia Privitera retweeted
NEW PREPRINT FROM THE LAB📢📢: Locus Coeruleus firing patterns selectively modulate brain activity and dynamics! 3y in the making and this work is finally seeing light thanks to a fantastic teamwork! C Grimm, S Duss and @BohacekLab. Short thread ⬇️ biorxiv.org/content/10.1101/…
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