A Wiley-partner journal focuses on the discovery of novel disease mechanisms and application of cutting-edge technologies to meet medical challenges.
Joined September 2022
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MedComm - Future Medicine retweeted
Artificial Intelligence in Traditional Chinese Medicine: Bridging Ancient Practice and Future Innovation - Jiang - 2025 - MedComm – Future Medicine - Wiley Online Library onlinelibrary.wiley.com/doi/…
Heart failure treatment is moving from "slowing the decline" to "restoring the function." The first trial of AB-1002 gene therapy showed that a single dose can significantly boost heart strength by repairing molecular calcium handling. onlinelibrary.wiley.com/doi/…
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A surprise for the clinic: AI modeling suggests 90.8% of patients currently receiving NAT before BCS might safely omit it without losing survival years. This could spare thousands from unnecessary side effects and costs. onlinelibrary.wiley.com/doi/…
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Pollution doesn't just damage your DNA; it changes how your body "reads" it. This study reveals how PM2.5 and ozone use epigenetic reprogramming to turn off protective genes and turn on inflammation, leading to COPD and asthma. onlinelibrary.wiley.com/doi/…
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Meet the "dark matter" of your gut. The virome contains 10x more particles than bacteria, with phages making up 95% of the population. These tiny viruses are the invisible architects of your internal health and disease. academic.oup.com/pcm/article…
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This synthesis of gut microbiota interactions with the immune system and advanced bacterial modification highlights the potential of microbiota-based therapies to improve clinical applications. bit.ly/4iD0jxQ
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CARS and Pyroptosis: Study found CARS expression decreased over time during IRI and is linked to pyroptosis, a form of programmed cell death. Modifying CARS alters ATP metabolism and pyroptosis-related proteins. bit.ly/44GwIgV
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Key Factors: Vaccinations may play a big role in shaping the presentation of Long COVID. Ongoing work focusing on Omicron-only populations is crucial for disease definitions and effective strategies. bit.ly/4pJ9H5o
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Next-Generation Sequencing (NGS) is key to cancer diagnostics and personalized treatment. It provides comprehensive insights into somatic and germline mutations, CNVs, and gene fusions. bit.ly/4iszzA3
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Platelets are crucial in tumor metastasis and poor prognosis! They form a protective microenvironment around circulating tumor cells (CTCs), shielding them from immune surveillance and shear forces. bit.ly/3Xkxf4o
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Functional enrichment showed activation of immune response and acute phase pathways alongside suppression of focal adhesion, actin cytoskeleton regulation, and platelet activation. bit.ly/48AJG2b
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Nature study highlights Interleukin-11 (IL-11) as a key driver of aging. Inhibiting IL-11 signaling extended median lifespan by up to 25% and improved healthspan in mice! bit.ly/3K6Jgr5
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Muscle Atrophy Models are crucial for research! Review summarizes animal models induced by aging, genetics, nutrition, exercise, disease, and drugs. Also includes in vitro and small organism models. bit.ly/4pz9Ecc
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DES is the most effective treatment for IS-CTO compared to Drug-Coated Balloons (DCB) (31.8%) and POBA (51.6%). Difference mainly due to fewer revascularizations with DES. bit.ly/4oZyzFW
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The Immunotherapy Resistance Score (IRS) demonstrated robust predictive accuracy against conventional indicators in multiple immunotherapy cohorts (including the HMU cohort). bit.ly/4oaZs8o
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Dysfunctional Neutrophils are a triple threat in WL: They promote NET formation (PADI4, MPO) & cytokine storms (S100A8/9/12, CXCL8). They also express T-cell suppressors (PD-L1, ARG1). bit.ly/4poxDur
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Brolucizumab (BeovuTM) is effective for nAMD/PCV fluid reduction but carries a risk of Intraocular Inflammation (IOI) and Retinal Vasculitis (RV). Case studies underscore the need for careful patient selection and monitoring. bit.ly/4oNVbsG
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Self-NCAPs showed strongest abscopal effect in a bilateral tumor model, eliminating both treated & untreated tumors! They induce durable, tumor-specific IFN-γ+CD8 T cell responses. bit.ly/43BRuxS
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The future of TNBC is combination: Immunotherapy (pembrolizumab, atezolizumab) with chemotherapy shows substantial efficacy in high-risk cases. Also exploring PARP/AKT inhibitors and ADCs (TROP2). bit.ly/48kPfla
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Lithocholic Acid (LCA) mimics Caloric Restriction (CR) by activating the TULP3-Sirtuin-v-ATPase-AMPK axis! LCA, a bile acid, offers a pharmacological analog for longevity. bit.ly/4icMtSA
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