Pharmacologist - Immunometabolism in Atherosclerosis and Stroke @UoBinfectionsch #Atherosclerosis #Stroke #Inflammation Science illustrator. Italobritish
England, United Kingdom
Joined June 2013
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Congratulations to Mary E. Brunkow, Fred Ramsdell & Shimon Sakaguchi, winners of the 2025 #NobelPrize in Medicine for uncovering how regulatory T cells (Tregs) maintain immune balance. A landmark in immunology shaping autoimmunity & cancer research. ๐ฌ๐
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RESEARCH | @mic_certo, @ClaudioMauro6 et al. (@unibirmingham):
Blocking lactate uptake by SLC5A12 offers therapeutic benefits in a mouse model of Sjรถgrenโs disease.
nature.com/articles/s42255-0โฆ
My new paper in EMBO Mol Med!
Using GeoMxยฎ + CosMxโข spatial transcriptomics, we mapped immune responses in human coronary arteries across #atherosclerosis.
embopress.org/doi/full/10.10โฆ
@unibirmingham
@unibirm_CMH
@UoBinfectionsch
@news_ub
#SpatialOmics #CardioResearch
Excited to share my piece on Springer Nature Research Communities: โUncovering a metabolic checkpoint in autoimmune inflammation: how lactate shapes immune hotspotsโ, based on my latest Nature Metabolism paper.
Read ๐ communities.springernature.cโฆ
@UoBinfectionsch @InflamAge_UoB
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Lactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution go.nature.com/4miXXoV
๐จ New paper out @NatMetabolism!
We show that lactate drives ectopic lymphoid structures in Sjรถgrenโs disease, and blocking SLC5A12 with our mAb 3C7 disrupts inflammation at its core.
๐ nature.com/articles/s42255-0โฆ
@unibirmingham
@unibirm_CMH
@UoBinfectionsch
@news_ub
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Thank you to @discovimmunol for highlighting our paper and sharing it on social media! We appreciate the support and hope readers enjoy exploring our work. #Immunology #immunometabolism @InflamAge_UoB @UoBinfectionsch
๐ฌ Targeting T-cell metabolism?
This study positions CARKL as a central modulator of T-cell bioenergetics, cytokines, and chemotaxis.
Could be a new node for immune modulation in disease.
๐ bit.ly/3XDlIh6
#Immunotherapy #ImmuneRegulation
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Jannik Sinner is the Wimbledon champion! ๐๐ฅ From prodigy to star, he conquers the grass and secures his place in history. The future is now. ๐ฎ๐น๐พ #Wimbledon #Sinner #ChampionsRise
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Weekend reading plot twist: Lactate isnโt just metabolic trash, itโs an immune system puppet master! From gene regulation to disease modulation, this โwasteโ is doing way more than we ever gave it credit for. Dive into our @Immunity review to see lactate in a whole new light.
I found this review extremely informative and highly recommend reading it! It provides a comprehensive overview of energy metabolism, its role in health and disease, and emerging therapeutic strategies. #metabolism
nature.com/articles/s41392-0โฆ
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๐ฅ New study: In inflamed skin, Treg cells expressing SSAT lose their suppressive function & shift to a TH17-like state, driven by 4-1BBL+ keratinocytes. Blocking SSAT restores Treg function, offering a targeted therapy for chronic skin inflammation!
cell.com/immunity/fulltext/Sโฆ
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Those who shout the loudest and threaten the most often do so to mask their own powerlessness. Strength doesnโt need to intimidate, it speaks for itself. #Trump et al.
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Super proud of our own Jordesh and Atrayee for presenting their research updates at todayโs @InflamAge_UoB seminar! Fantastic work and great discussions. Well done! #Research #Teamwork
Activating PKM2 in macrophages boosts IL-10 production via glycolytic ATP, converted to adenosine signaling through A2a receptors. This links glycolysis to anti-inflammatory responses and improves mitochondrial health.
sciencedirect.com/science/arโฆ
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Explore metabolic regulators of T cell migration with @mic_certo @ClaudioMauro6 et al. @unibirmingham in December's Outstanding Article from @discovimmunol
academic.oup.com/discovimmunโฆ
We're collaborating with @discovimmunol @britsocimm to share great science!
November's Outstanding Article is all about monocytes โ from the guardians of health to the regulators of disease. Check it out here: bit.ly/4fNIEky
New study reveals dendritic cell roles in rheumatoid arthritis: inflammatory DC3s drive synovitis, while tolerogenic DC2s are lost. Targeting DC3s or restoring DC2s could transform RA treatment. A groundbreaking read for immune therapy research!
cell.com/immunity/fulltext/Sโฆ
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Rheumatoid arthritis is driven by metabolic rewiring: T cells & macrophages adapt to glucose-deprived joints, fueling inflammation via glutamine use and mitochondrial dysfunction. A must-read on how cellular metabolism shapes RA pathology!
sciencedirect.com/science/arโฆ
Excited to share our latest publication! We uncover how CARKL, a key enzyme in the PPP, reshapes T cell metabolism, affecting respiration, ATP, cytokines, and migration. Insights into immune regulation and potential therapies! #Immunometabolism #TCells
academic.oup.com/discovimmunโฆ
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