@ImmunityCP

Cutting-edge research in immunology from around the world. This account is no longer monitored, and content is automated. Join us on LinkedIn!

 Cambridge, MA, USA
cell.com/immunity
Joined May 2011
  • Tweets11.4K
  • Following318
  • Followers72.2K
2KMedia
We are turning this account into a fully automated page. To learn more about what’s going on at Immunity, please follow us on LinkedIn! linkedin.com/company/immunit…
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Online now: NF-κB phosphorylation controls enhancer selection to shape the inflammatory gene program dlvr.​it/TW2L64
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Why Some People Age Like Fine Wine CD8 cells in the immune system appear to reflect how healthy one's old age will likely be and could lead to a diagnostic test of aging. thedoctorwillseeyounow.com/c… #Aging #agingwell #immunity @ImmunityCP #immunehealth #inflammation #Granzymes #CD8
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Why does it take repeated exposures to become allergic, and why does one allergy lead to others? I talked with Claudia Hammond on BBC Health Check about our new @ImmunityCP paper: sensory neurons in mice remember allergen exposure. 🎧 podcasts.apple.com/us/podcas…

Solving the mystery of allergies

Podcast Episode · Health Check · October 21 · 26m

podcasts.apple.com
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Embracing macrophage complexity for research and translation. cell.com/immunity/fulltext/S… @ImmunityCP

Embracing macrophage complexity for research and translation

Ginhoux, Mulder, Arcila-Barrera, and Amit argue that macrophage identity is best understood not as a set of discrete subsets or a binary M1/M2 axis but as combinations of modular gene programs. They...

cell.com
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Immunity retweeted
Eric Topol
@EricTopolOct 16
Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions cell.com/immunity/fulltext/S… @ImmunityCP
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IdoAmitLab@IdoAmitLabOct 16
What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy cell.com/immunity/abstract/S…

Embracing macrophage complexity for research and translation

Ginhoux, Mulder, Arcila-Barrera, and Amit argue that macrophage identity is best understood not as a set of discrete subsets or a binary M1/M2 axis but as combinations of modular gene programs. They...

cell.com
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This @ImmunityCP study found that #microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation. 📖 bit.ly/47jOSWW First authors Evi Paouri and Sarah Stanko show that genetic deletion of microglial Myd88 protect against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing #ECM disruption.
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Online now: Embracing macrophage complexity for research and translation dlvr.​it/TVxZsp
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Online now: Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment dlvr.​it/TVwwlg
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Online now: Dan Kastner (1951–2026) dlvr.​it/TVwpWt
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Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in #colitis models, @WeizmannScience researchers showed that colonic #ECM underwent lasting pathological reprogramming following inflammation. 🔎 bit.ly/3VL0FuQ Their findings, published in @ImmunityCP, redefine the ECM as a long-lived instructive compartment that encodes injury memory and promotes maladaptive regeneration.
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Can our immune system remember a virus for 20 years? Prof. Zhang Linqi’s Innovative Tsinghua team @MedTsinghua found that SARS-CoV-1 immune memory can endure for two decades in @ImmunityCP, providing new insights for broader vaccines with @HKUniversity and other collaborators.
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Immunity retweeted
Eric Topol
@EricTopolOct 12
Unraveling the immune system's role in our healthspan Breaking down a seminal study just published @ImmunityCP erictopol.substack.com/p/a-t…
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Online now: Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis dlvr.​it/TVtT2v
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John Lukens@LukensJohnROct 6
Induced regulatory B cells stably expressing interleukin-10 reverse central nervous system autoimmunity by targeting myeloid cells. @ImmunityCP cell.com/immunity/fulltext/S…
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Out in @ImmunityCP : We expanded to >2,500 TCRs and 8 epitopes and find that ~half of TCR-pMHC pairs do not validate. On clean data, we show that modeling reactivity with AF3 & tcrdist3 is more feasible than assumed. Is your model better? Join IMMREP26! 🧵 cell.com/immunity/fulltext/S…

Functional evaluation of TCR-pMHC pairs at scale allows in silico TCR reactivity prediction

Messemaker et al. develop a TCR rapid assembly platform (T-RAP) and use it to generate a large high-quality dataset of functionally validated TCR-pMHC pairs. With the resulting validated TCR-pMHC...

cell.com
MariusMessemaker@MariusMessemak12 May 2025
It's not the models, it's the data! We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.🧵 biorxiv.org/content/10.1101/…

A functionally validated TCR-pMHC database for TCR specificity model development

Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC...

biorxiv.org
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Immunity retweeted
Eric Topol
@EricTopolOct 11
A seminal paper on aging of our immune system was just published. From study of over 12 million single-cells in 8 cohorts, >2,600 individuals, ranging in age from 18 to 98. Yielding a practical blood test. And much more. A Tale of Two T cells In the new Ground Truths
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CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @ImmunityCP cell.com/immunity/fulltext/S… @maxim_artyomov @WashU @nikart89 @NationwideKids @KingsCollegeLon
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Lymph node lymphangiogenesis encapsulates activating germinal centers to constrain their size, which enhances clonal selection and protective antibody responses @ImmunityCP cell.com/immunity/fulltext/S… @nyugrossman @theLundLab
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Immunity retweeted
John Lukens@LukensJohnROct 8
Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse. @ImmunityCP cell.com/immunity/fulltext/S…

Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments,...

Alcohol’s brain effects are attributed to neurons, leaving microglial functional involvement untested. Paouri, Stanko, et al. show that microglia drive alcohol-induced sedation, motor impairment, and...

cell.com
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