@Michael_Kug

Postdoctoral researcher in the @hopfnerlab, @GeneCenter_LMU #structuralbiology #innateimmunity PhD at @IOCBPrague / @imgprague under @VSCHT

 Munich, Bavaria
researchgate.net/profile/Michael_Kugler2
Joined April 2019
  • Tweets47
  • Following158
  • Followers70
Our second SLFN11 story is out! Huge thanks to my wonderful co-authors and colleagues Felix Metzner, Gregor Witte and @KatjaLammens in @hopfnerlab at @GeneCenter_LMU. Now online at @NatureComms.
hopfnerlab@hopfnerlab3 Dec 2024
SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities. Check out our new paper at: nature.com/articles/s41467-0… + movie
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Michael Kugler retweeted
Munich RNA Club@MunichRNA29 Jan 2025
Join us in our next #MunichRNA19F! 📍 @MPI_Biochem 📅 19/02/2025 We will hear amazing talks from Shuyao Sha (@kusterlab ), @lauradmartens (@gagneurlab), @Michael_Kug (@hopfnerlab), Marc Schmitt-Supprian. Don't miss it! 🧬😀
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Thanks to all the attendees, speakers and discussion leaders that made the 2024 3DEM GRC grc.org/three-dimensional-el… an exciting and memorable event! #3dem
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The #Schlafen11 protein, identified as sensor for single stranded DNA #ssDNA, may be part of new class of pattern recognition receptors. Read more: scim.ag/7kA
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An inspiring example! Petr Těšina moved back to Czechia from Germany (LMU) when he won an ERC Starting Grant. It allows him to set up a research team at @CEITEC_Brno and take his cutting-edge to new levels. @petesoi1
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Michael Kugler retweeted
Munich RNA Club@MunichRNA7 Mar 2024
In our next meeting #MunichRNA20M, we will hear the amazing RNA science of Yung-Li Chen from @METorresPadilla lab (@Helmholtz_MUC) and @Michael_Kug from @hopfnerlab (@LMU_Muenchen). Hope to see you there! 📅20/03/24 3pm 📍@MPI_Biochem
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Michael Kugler retweeted
Michael Trakselis@Trakselis2 Aug 2023
@FASEB #HNASRC #Helicase23 is a wrap. Had a great time connecting with old friends, meeting some great new folks, and learning loads about RNA and DNA helicases. What a great turnout and lineup! Looking forward to #Helicase25!
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Michael Kugler retweeted
WilsonLab@WilsonLab28 Aug 2023
Our study on the "structural conservation of antibiotic interaction with ribosomes" is out in @nsmb. Mammoth effort led by Helge Paternoga and @caillancm reporting structures of 17 antibiotics in complex with the ribosome at 1.6-2.2Å resolution...PDF at... nature.com/articles/s41594-0…

Structural conservation of antibiotic interaction with ribosomes

Nature Structural & Molecular Biology - Here the authors present the high-resolution structures of 17 antibiotics bound to Escherichia coli ribosomes, which may inform the development of new...

nature.com
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Michael Kugler retweeted
hopfnerlab@hopfnerlab30 Jun 2023
Check out how the INO80 complex interacts with non-canonical nucleosomes. Great team effort by M. Zhang, A. Jungblut and F. Kunert. Congratulations to the @EustermannLab @embl and all authors!!! science.org/doi/10.1126/scie…
EMBL@embl30 Jun 2023
New EMBL research by the Eustermann lab reveals how the packaging of DNA into hexasomes impacts the function of remodeling enzymes involved in gene regulation. Read more: science.org/doi/10.1126/scie…
image credit: Luis Hauptmann / EMBL

ALT image credit: Luis Hauptmann / EMBL

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The 1st international Schlafen (SLFN) meeting was held @broadinstitute this week. Amazing to meet colleagues all working in an under-researched group of genes/proteins. Can’t wait for the next…..#slfn #genetics #schlafen #sleep
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Michael Kugler retweeted
Petr Těšina@petesoi117 Feb 2023
Here's a thread about our recent eukaryotic RQC publication in @MolecularCell, which was my last project in the @BeckmannLab. Thanks to @inada_lab and all co-authors!
Beckmann Lab@BeckmannLab17 Feb 2023
Check our most recent work in collaboration with the amazing @inada_lab. The study unveils the molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. #ribosome #cryoEM #MolecularCell Here's a thread with the most exciting findings🧵...
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Glad to help regarding better understading of B–H⋯π and C–H⋯π hydrogen interactions on carbonic anhydrase II/carborane-based inhibitors - combination of X-ray crystallography and quantum-chemical calculations. @IOCBPrague @iic_rez @nekwajz
This Post is from an account that no longer exists. Learn more
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Michael Kugler retweeted
hopfnerlab@hopfnerlab12 Dec 2022
Check out our newest publication. Great work by Franziska Kunert and Felix Metzner! Thanks to all authors for the team effort. @MarkusHopfler @PfanderLab S.Eustermann et al. Structural mechanism of extranucleosomal DNA readout by the INO80 complex science.org/doi/10.1126/scia…
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The saga of carbonic anhydrase inhibitors continues - by using three different approaches we were exploring the potential exosite of carbonic anhydrases. Fruitful collaboration at @IOCBPrague. Out now at @rsc_medchem. pubs.rsc.org/en/content/arti…

Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display...

The development of highly active and selective enzyme inhibitors is one of the priorities of medicinal chemistry. Typically, various high-throughput screen

pubs.rsc.org
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Michael Kugler retweeted
cryoEM Papers@cryoEM_Papers1 Dec 2022
Fast cryo-electron tomography data acquisition to determine molecular structures in situ nature.com/articles/s41592-0…

Fast cryo-electron tomography data acquisition to determine molecular structures in situ

Nature Methods - To accelerate data acquisition for in situ cryo-electron tomography, we created a method that takes into consideration sample geometry for the robust prediction of sample movement...

nature.com
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Today we introduced Chroma, a generative model that creates new proteins & protein complexes given geometric & functional constraints. It learns to transform unstructured, random 3D shapes into #protein molecules, which can have tens of thousands of atoms. ow.ly/Txn750LShFp
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Released today @EMDB_EMPIAR & @PDBeurope, & published @natcomms, #CryoEM structures of the Human Schlafen-11 dimer apoenzyme. Study by F. J. Metzner et al., from @GeneCenter_LMU @ 2.8 Å resolution.
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Glad to be a part of the SLFN11 story with Felix Metzner, @simonjwenzl and @KatjaLammens in @hopfnerlab at @GeneCenter_LMU. Now online at @NatureComms.
hopfnerlab@hopfnerlab19 Sep 2022
Cryo-EM structures of human SLFN11 bound to tRNA or ssDNA uncover the tRNA endoribonuclease mechanism and how it may block stressed replication forks. Check out our new paper at: nature.com/articles/s41467-0…
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Michael Kugler retweeted
Ben Engel@bengeliscious21 Jul 2022
Excited to share our new study with the Müller and @SchullerJm labs, online @nature: nature.com/articles/s41586-0… This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of the enzyme HDCR 🍩 1/🧵
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