Updates and insight on the MS-STAT2 study from the team at UCL. A phase 3 clinical trial of high dose simvastatin for secondary progressive multiple sclerosis
London, England
Joined April 2019
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MS-STAT2 retweeted
Today the results of the MS-STAT2 trial were announced by Professor Jeremy Chataway at the ECTRIMS research conference in Copenhagen.
This trial tested simvastatin, commonly used to treat high cholesterol, in 964 people with secondary progressive MS. (1/6)
Registration and abstract submission are open for MS Frontiers conference!
This year the MS Society are hosting their MS research conference at the University of Liverpool.
Find out all about it and how to register via their website:
mssociety.org.uk/research/fo…
MS-STAT2 retweeted
Thank you @StuStepsUp+Marie for inspiring work @mssocietyuk @mscymru Ambassadors for people with #MS #AdvancedMS Check out chariotms.com #ChariotMS @QSMSCENTRE @MsStat2 @OctopusTrial @AttackMS_trial @the_MSBlog #MS @RachelHorne19 @themsguide @aid4disabled #NHS75 #GIG75
Recently retired nurse & general manager and MS ambassador @StuStepsUp talks candidly about his experience of working in the NHS with MS over the last 40 years and how demand has changed vastly over that time.
#NHS75 #GIG75
MS-STAT2 retweeted
Excellent @EANeurology #EAN2023 update on our expanded knowledge of #MS CNS compartmentalised inflammation and the exciting near future of BTK Inhibitors by Wallace Brownlee, Veronica Popescu and Martin König
@DrWBRO @VeroPopescu
MS-STAT2 retweeted
Great to be in Budapest for #EAN2023 discussing PIRA, compartmentalized CNS inflammation and BTK inhibitors with Veronica Popescu and Marton König @VeroPopescu @EANeurology
MS-STAT2 retweeted
What is MS progression? Our understanding of progress independent of disease activity (PIRA) has grown over the last 20 years, with clinical and real world studies confirming that once relapses are controlled with DMTs progression can still happen!
MS-STAT2 retweeted
An excellent overview of #SMOULDERINGMS - how we see progression independent of relapses #PIRA, what processes are involved and what #biomarkers will let us ultimately lead to individualized treatment!
MS-STAT2 retweeted
#BrainAtrophy and #CognitiveImpairment in #MS - Closely interlinked, and of great importance to PWMS. Cognitive impairment being associated with more care needs and worse quality of life - focus on slowing/stopping this is essential!
MS-STAT2 retweeted
#BigData in #MS - a great overview of the incorporation of all the -omics (genomic, metabolomics, proteomics, etc) towards novel understanding and treatments for #PMS #ProgressiveMS
The European Academy of Neurology 2023 conference! Let's talk #MS #BigData #Biomarkers #SmoulderingMS #clinicaltrials #PIRA and much more!
Great question! It's very hard from a single study to be sure if it's
atrophy->CVR, or
CVR->atrophy, or
<->
There is a lot of evidence of CVR impacting brain function long term generally tho! More work is ongoing and we think simva might have a direct role in PMS protection!
Hot off the press! The first STAT2 research paper - Cardiovascular Risk Factors in SPMS and how they impact brain volumes and memory.
onlinelibrary.wiley.com/doi/…
Thank you to all our participants for their time and contribution!
#MSAwarenessWeek - how does MS make you feel? Does it affect you personally, or someone you know?
Our amazing colleague Dr Alessia Bianchi @alessia_bia completing the London marathon to fundraiser for the @mssocietyuk!
If you'd like please donate via: 2023tcslondonmarathon.enthus…
STAT2 has EDSS primary with many others, including 9HPT, 25FW, and the detailed BICAMS cognitive assessments as secondary outcomes.
OCTOPUS slightly complicated as multi-phase, but the phase 3 element likely to use a composite primary (EDSS, 9HPT and 25FW), similar to ASCEND.
High levels of nerve damage detected in blood probably a bad thing whether on simvastatin or placebo. But the statin did preserve brain volume and performance on some thinking tests as well - so looked promising.
We will look at this again in STAT2, but need to wait for all the final visits to be completed first.
Hi Cathy. This analysis (using the previous MS-STAT1 trial data) showed that those with having higher levels of nerve damage in your blood at the beginning of the trial was associated with some worsening of cognition over the next 2 years.
MS-STAT2 retweeted
Higher serum neurofilament light chain (sNfL) is linked to more cognitive decline in MS. Data from the MS-STAT study (simvastatin vs. placebo in progressive MS) pubmed.ncbi.nlm.nih.gov/3594…
