@NeuroStemCell

Everything about #NeuroStemCells #StemCells #BrainOrganoids Research. Curated by @DrRaulDM

Joined March 2016
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Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis ift.tt/DAd8QEL
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Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis ift.tt/iNojg3F

Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis - PubMed

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms...

pubmed.ncbi.nlm.nih.gov
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High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal Oscillations and Potential Seizure Risk Based on Ca2+ Fluorescence Measurements in Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neuronal 2D and 3D Cultures ift.tt/u5RhO8t

High-Throughput Screening Assay for Detecting Drug-Induced Changes in Synchronized Neuronal...

Drug-induced seizure liability is a significant safety issue and the basis for attrition in drug development. Occurrence in late development results in increased costs, human risk, and delayed market...

pubmed.ncbi.nlm.nih.gov
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Use of in vitro derived human neuronal models to study host-parasite interactions of Toxoplasma gondii in neurons and neuropathogenesis of chronic toxoplasmosis ift.tt/p7LV2Ee

Use of in vitro derived human neuronal models to study host-parasite interactions of Toxoplasma...

Toxoplasma gondii infects approximately one-third of the world's population resulting in a chronic infection with the parasite located in cysts in neurons in the brain. In most immunocompetent hosts...

pubmed.ncbi.nlm.nih.gov
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Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits ift.tt/SCjq2p0

Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and...

Amyloid precursor protein (APP) produces aggregable β-amyloid peptides and its mutations are associated with familial Alzheimer's disease (AD), which makes it one of the most studied proteins....

pubmed.ncbi.nlm.nih.gov
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Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro-in vivo extrapolation ift.tt/s70HuEm

Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in...

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied...

pubmed.ncbi.nlm.nih.gov
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Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization ift.tt/eK0iFvH

Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo...

The critical requirements in developing clinical-grade human-induced pluripotent stem cells-derived neural precursors (hiPSCs-NPCs) are defined by expandability, genetic stability, predictable in...

pubmed.ncbi.nlm.nih.gov
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Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets ift.tt/J01D7o6

Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid...

Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin (HTT) gene. The resulting polyglutamine (polyQ) tract alters the function of the HTT...

pubmed.ncbi.nlm.nih.gov
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Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders ift.tt/2jLqZDH

Protein interaction studies in human induced neurons indicate convergent biology underlying autism...

Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-pro...

pubmed.ncbi.nlm.nih.gov
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The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism ift.tt/uq8x3V0
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Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18 ift.tt/5jtA7nl

Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18 - PubMed

HCN4 channels are considered to be a promising target for cardiac pathologies, epilepsy, and multiple sclerosis. However, there are no subtype-selective HCN channel blockers available, and only a few...

pubmed.ncbi.nlm.nih.gov
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Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics ift.tt/zev9Vfu

Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative...

The development of neural interfaces with superior biocompatibility and improved tissue integration is vital for treating and restoring neurological functions in the nervous system. A critical factor...

pubmed.ncbi.nlm.nih.gov
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Directed differentiation of human induced pluripotent stem cells into midbrain ift.tt/YERTk2a

[Directed differentiation of human induced pluripotent stem cells into midbrain] - PubMed

HiPSCs can be effectively induced to differentiate into DAPs capable of differentiating into functional neurons both in vivo and in vitro. In rat models of PD, the transplanted hiPSCs-DAPs can...

pubmed.ncbi.nlm.nih.gov
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Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differentiated Human Cortical Neurons ift.tt/47MQijH

Human Cytomegalovirus Induces Significant Structural and Functional Changes in Terminally Differe...

Human cytomegalovirus (HCMV) is a highly prevalent viral pathogen that typically presents asymptomatically in healthy individuals despite lifelong latency. However, in 10-15% of congenital cases,...

pubmed.ncbi.nlm.nih.gov
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Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival ift.tt/KGvQMJA

Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain...

Introduction: Caveolin-1 and Caveolin-2 (CAV1 and CAV2) are proteins associated with intercellular neurotrophic signalling. There is converging evidence that CAV1 and CAV2 (CAV1/2) genes have a role...

pubmed.ncbi.nlm.nih.gov
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Development of a functional human induced pluripotent stem cell-derived nociceptor MEA system as a pain model for analgesic drug testing ift.tt/5izaOTS

Development of a functional human induced pluripotent stem cell-derived nociceptor MEA system as a...

The control of severe or chronic pain has relied heavily on opioids and opioid abuse and addiction have recently become a major global health crisis. Therefore, it is imperative to develop new pain...

pubmed.ncbi.nlm.nih.gov
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iPSC-sEVs alleviate microglia senescence to protect against ischemic stroke in aged mice ift.tt/6PLfXh7
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Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination ift.tt/71tAWYj

Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendroc...

Developing an in vitro platform to study neuron-oligodendrocyte interaction, particularly myelination, is essential to understand aberrant myelination in neuropsychiatric and neurodegenerative...

pubmed.ncbi.nlm.nih.gov
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Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD ift.tt/nbWxhej
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Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability ift.tt/m8S5hsU

Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived...

Chronic pain is highly prevalent and remains a significant unmet global medical need. As part of a search for modulatory genes that confer pain resilience, we have studied two family cohorts where...

pubmed.ncbi.nlm.nih.gov
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