@ObarLab

Professor @GeiselMed @Dartmouth @DMS_MicroImmuno; Laboratory of Antifungal Immunity // Director @MCBDartmouth // JV Soccer Coach @hcaneswirl

 Lebanon, NH
geiselmed.dartmouth.edu/obar/
Joined March 2020
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Recently published work in our lab identified keratinocyte VISTA as an epidermal checkpoint that restrains skin type I IFN response and UV light-induced injury. #lupus #photosensitivity @ZacharyTPeters @JCI_insight @GeiselMed @MCBDartmouth insight.jci.org/articles/vie…
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Congratulations to boys soccer for securing the SVL-B title last night! This is league title #17 for the program and 5th in the last 8 seasons. (1991, 1993, 1995, 1996, 1997, 1998, 2003, 2004, 2009, 2011, 2012, 2013, 2019, 2022, 2023, 2024, 2026). Well done Canes!!
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We are hiring - at the new Center for Pathogen Immunology in the Department of Microbiology @nyugrossman @nyulangone linkedin.com/jobs/view/44746…

Assistant Professor, Center for Pathogen Immunology at NYU Langone Health — New York, NY | LinkedIn...

Apply for Assistant Professor, Center for Pathogen Immunology at NYU Langone Health in New York, NY. Full-time Not Applicable role. See responsibilities, qualifications, and similar jobs on LinkedIn.

linkedin.com
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Thrilled to share this labor of love, #freshoffthepress in @Nature about how Type 2 immune history trains lung macrophages for viral disease tolerance.👇 nature.com/articles/s41586-0… This was impossible without my mentor @Kamal_M_Khanna & our coauthors. 🧵 on 🦋payalyokota.bsky.social

Type 2 immune history trains lung macrophages for viral disease tolerance

Nature - Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without...

nature.com
Kamal M Khanna@Kamal_M_KhannaSep 30
Happy to share our new paper in @Nature “Type 2 immune history trains lung macrophages for viral disease tolerance” nature.com/articles/s41586-0… the work was fearlessly led by @PayalYokota Thanks to all our collaborators! @nyulangone @nyugrossman

Type 2 immune history trains lung macrophages for viral disease tolerance

Nature - Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without...

nature.com
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Happy to share our new paper in @Nature “Type 2 immune history trains lung macrophages for viral disease tolerance” nature.com/articles/s41586-0… the work was fearlessly led by @PayalYokota Thanks to all our collaborators! @nyulangone @nyugrossman

Type 2 immune history trains lung macrophages for viral disease tolerance

Nature - Type 2 inflammation trains nerve- and airway-associated macrophages to confer disease tolerance against lethal influenza by limiting immunopathology and promoting tissue repair without...

nature.com
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🚨Spaces are filling up fast for the 2027 GRC Immunology Fungal Infections meeting - submit your application now to avoid missing out! Full program available next week but you can see the invited speakers here: grc.org/immunology-of-fungal…
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Our new studies show that neutrophils increase in the urine of #lupus patients with active skin disease, in LN kidneys, and after skin exposure to UV, promoting renal tissue remodeling. @J_Immunol @andreafaa @GeiselMed @DartmouthHealth @MCBDartmouth academic.oup.com/jimmunol/ar…

A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodel...

Abstract. Neutrophils have been implicated in mediating immune crosstalk between injured tissue and distal organs, either promoting local and distal inflam

academic.oup.com
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We previously showed that APS-1/APECED features excess IFNg responses that can be targeted therapeutically (Oikonomou NEJM 2024). We now extend this to show that early JAK inhibition can intercept the development of irreversible autoimmune endocrinopathies nature.com/articles/s41467-0…

Ruxolitinib prevents irreversible autoimmune endocrinopathies in APECED

Nature Communications - APECED is a monogenic autoimmune disorder resulting from deleterious variants in the Autoimmune Regulator gene. Here, the authors report the cases of two patients with...

nature.com
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📢 The abstract deadline for the 2027 Gordon Research Conference on Immunology of Fungal Infections is approaching. Submit by September 1, 2026 for consideration for a short talk.#FungalImmunology #GRC See details: grc.org/immunology-of-fungal…
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MCB Students and Alumni: The 4th Annual Gary Heussler Alumni Lecture will be presented Sept. 18th by Megan O'Connor! The lecture will be followed by a networking event to connect students and alumni. Alumni: If you didn't get an email last Friday, please comment/DM!
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Thrilled to share my second postdoc paper, out today in @SciImmunology. We continued dissecting the host response to fungal pathogens in the lung and uncovered another spatial circuit that shapes macrophage function and pathogen persistence.
Science Immunology@SciImmunologyJul 17
#Macrophage-derived cholesterol metabolites called oxysterols recruit immunosuppressive T helper 2 (#TH2) cells to fungal lesions in the lungs of mice. @EricVDang1 @yufanzheng7 Learn more in Science #Immunology: scim.ag/4wO0cFq
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A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned. cell.com/immunity/fulltext/S…
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inquirer.com/opinion/comment…

Persistence and funding will determine scientific progress | Opinion

As funding for American scientific research dries up, fewer promising ideas move forward.

inquirer.com
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Championship Day! Boys lax heads to Burlington to face #1 Harwood in a 6:00 game at Virtue Field (UVM). Tickets available on GoFan or at the gate. Fan bus departs at 4:15 from HHS. Might want to bring some rain gear... #GoCanes!!!
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👉 HIF activity prevents proper macrophage maturation Deleting VHL → stabilizes HIFs → immature AM phenotype Only removing BOTH HIF-1α + HIF-2α fully restores identity 👉 HIF signaling is the dominant driver downstream of VHL
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ObarLab retweeted
Ivan Zanoni
@Lo_ZanziMay 22
#InterferonPower! #InflammasomePower! 💥With @kjena21 &co we show @NatImmunol that our fungal adjuvant #Mannadjuvant, via IL1 & IFNs, prolongs & potentiates protection of #mRNA #vaccines, broadening it to new variants & overcoming antigenic imprinting! 👉 nature.com/articles/s41590-0…

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines

Nature Immunology - Jena, Qu et al. show that mannadjuvant, a formulation of fungal mannan and aluminum hydroxide, increases the magnitude, durability and breadth of the response elicited by...

nature.com
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ObarLab retweeted
Ivan Zanoni
@Lo_ZanziMay 10
#WeekendRead! #InterferonPower! Cook, Green &co show @JCellBiol that macrophage cell #volume controls their inflammatory response & that macrophage #swelling increases IFN induction synergizing with pathogen-associated molecular pathways! doi.org/10.1083/jcb.20241113…

Disruption of macrophage cell volume drives inflammatory responses and type I interferon signaling

Cook et al. show that macrophages sense cell volume disruption as a danger signal promoting transcriptional reprogramming and inflammatory responses via ty

rupress.org
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ObarLab retweeted
CFI-UMN@CFI_UMNMay 6
🚨 We’re hiring! Assistant Professor in Immunology @ UMN CFI + LMP seek researchers (including but not limited to inflammation, infection, cancer, neuro, systems immunology). 📍 hr.umn.edu/jobs/Find-Job 🧪 Job ID: 373424 Please share! #Immunology #AcademicJobs#FacultyJobs
🤖 Made with AI
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Trained Immunity friends, we are excited to see you in Montreal in the Fall ! Register w the early bird rate 🫶
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Latest data from the lab out now in mBio. We show that the antibiotic vancomycin directly impairs antifungal function of macrophages via mitochondrial dysfunction. Lots of lovely imaging in this one from @EbRyhmer ! Check it out here: journals.asm.org/doi/10.1128… #antibiotics #fungi – at Birmingham, England

Vancomycin disrupts mitochondrial morphology and function and impairs macrophage fungal killing |...

Antibiotics are widely prescribed drugs used to treat bacterial infections; however, their use may increase the likelihood of developing life-threatening fungal infections in vulnerable patients....

journals.asm.org
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