Biophysicist/Modeller playing with tissues in Development and Regeneration School of Biosciences, University of Nottingham Also in @osvaldo-chara.bsky.social
Joined May 2016
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🧵 New protocol out in @STARProtocols! We present a step-by-step guide for inferring mechanical stresses in tissues using ForSys, by @BorgesAugust, @hey_jero, @CeccarelliAS, @gbventur, @ksedzinski, @LopezSchier365 & @Osvaldo_Chara
cell.com/star-protocols/full…
Osvaldo Chara retweeted
Pues en este artículo que hemos publicado en la revista @NatureComms mostramos el descubrimiento del primer metamaterial programable natural. Y tú dirás… ¿y eso qué es? Pues algo que en el futuro podrá ser muy útil.
Aquí va el link: nature.com/articles/s41467-0…
Tira del hilo...
Scripting is also easy! Load your images into Frame objects, then pass them to ForSys: import forsys as fs → build frames{} per timepoint → forsys = fs.ForSys(frames) and then infer. Works for both experimental 🔬 and in silico 💻 data!
Thanks to all co-authors, labs, and collaborators! ForSys is free & open source. Find the detailed usage description in the Protocol (cell.com/star-protocols/full…) and the code, example notebooks & full docs here: github.com/borgesaugusto/for… Happy inferring! 🫧🔬
Osvaldo Chara retweeted
🔬 Diverse species. Stem cells. Highly international team. 🐸🐭
We’re looking for a Technical Assistant to join our stem cell–based research.
Interested?
Apply here 👉 jobs.tue.mpg.de/jobs/276
Would you like to run our Cellular Potts Model (#CPM) of neuromast regeneration in #zebrafish? It is now available in the amazing #Morpheus repository:
morpheus.gitlab.io/model/m43…
Curious about the Science? Check our paper: doi.org/10.1016/j.jtbi.2026.…
Thrilled to share this adventure on how zebrafish elongates its notochord! 🐟 Kudos to Carlos Camacho de la Macorra and @BenSteventon2 for leading it. @CeccarelliAS and I had so much fun modelling & uncovering unexpected predictions...
biorxiv.org/content/10.64898…
A nice mix of maths 📐, computing 💻 & experiments 🔬! This adventure took place at @Cambridge_Uni , @UoNBiosciences and @UADEoficial !
Osvaldo Chara retweeted
8.II
Our Mathematician of the Day is Daniel Bernoulli a Dutch-born member of the Swiss mathematical family. His most important work considered the basic properties of fluid flow, pressure, density and velocity, and gave the Bernoulli principle.
mathshistory.st-andrews.ac.u…
Our results show that the tissue-wide regenerative response of the neuromast is consistent with a delayed proliferation switch modulated by the the number of neighbors.
(6/9)
Comparison of the model simulations with experiments on regenerating neuromasts previously subjected to laser ablation suggests that our hypothetical proliferation switches are a robust mechanism of regeneration control.
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Curious about how to achieve organ-wide #regeneration through locally controlled cell proliferation? Check out our latest computational adventure addressing this problem in the #neuromast within the #zebrafish lateral line.
doi.org/10.1016/j.jtbi.2026.…
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We parameterized the CPM using our recent estimates of cell-cell interactions within the neuromast using our new method of Mechanical Stress Inference ForSys!
doi.org/10.1016/j.isci.2025.…
Interestingly, these interactions allow the integrity of the organ to be maintained.
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How do we get such an ordered structure after the chaos of laser ablation? We decided to investigate this problem quantitatively by using a Cellular Potts Model (CPM).
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Neuromasts are known to have a remarkable regenerative capacity! Hernán's lab has previously shown that after laser ablation of up to 90% of a neuromast, sustentacular & mantle cells undergo an ordered proliferation-dependent regenerative response.
elifesciences.org/articles/3…
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