@PZMLLC

We are interested in development of novel diagnostics for cancer and autoimmune diseases so the results are faster and more accurate.

 San Diego, CA
Joined April 2015
  • Tweets1.5K
  • Following4K
  • Followers1.9K
101Media
Remarkable ! nature.com/articles/s41551-0…

Tumour-resident oncolytic bacteria trigger potent anticancer effects through selective intratumou...

Nature Biomedical Engineering - A tumour-derived consortium of Proteus mirabilis and Rhodopseudomonas palustris eradicated diverse tumours in immunocompromised and immunocompetent animal models via...

nature.com
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PZM Diagnostics retweeted
NEJM
@NEJMSep 23
Original Article: Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis (NHS-Galleri trial) nej.md/4xRZN5L Editorial: A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer nej.md/4cK3UIy #Oncology #Genetics
Panels A–D are graphs that show the risk of diagnosis of stage III or IV cancer among the 12 prespecified cancer types, of stage IV among the 12 prespecified cancer types; of stage III or IV among all routinely staged cancer types, and of stage IV among all routinely staged cancer types. Panels E and F are bar charts that show the distribution of cancers according to stage and trial group for the 12 prespecified cancer types (post hoc analysis) and for all routinely staged cancer types.

ALT Panels A–D are graphs that show the risk of diagnosis of stage III or IV cancer among the 12 prespecified cancer types, of stage IV among the 12 prespecified cancer types; of stage III or IV among all routinely staged cancer types, and of stage IV among all routinely staged cancer types. Panels E and F are bar charts that show the distribution of cancers according to stage and trial group for the 12 prespecified cancer types (post hoc analysis) and for all routinely staged cancer types.

Bar chart comparing detection methods of two groups, Intervention Group (N=3637) and Control Group (N=3400). For the Intervention Group, clinically detected: 2464, MCED-detected: 937, NHS current screening program-detected: 236. For the Control Group, clinically detected: 3110, MCED-detected: 0, NHS current screening program-detected: 290. The colors represent each detection method: green for clinically detected, red for MCED-detected, and yellow for NHS detection.

ALT Bar chart comparing detection methods of two groups, Intervention Group (N=3637) and Control Group (N=3400). For the Intervention Group, clinically detected: 2464, MCED-detected: 937, NHS current screening program-detected: 236. For the Control Group, clinically detected: 3110, MCED-detected: 0, NHS current screening program-detected: 290. The colors represent each detection method: green for clinically detected, red for MCED-detected, and yellow for NHS detection.

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Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…

Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis | NEJM

Whether screening with blood-based early-detection tests for multiple cancers in addition to usual care has clinical utility is unknown. In a randomized, controlled trial conducted in England, we o...

nejm.org
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Congenital soft tissue sarcoma of the neck with placental metastasis: a case report | Surgical and Experimental Pathology | Springer Nature Link link.springer.com/article/10…

Congenital soft tissue sarcoma of the neck with placental metastasis: a case report

Surgical and Experimental Pathology - Congenital round cell soft tissue sarcoma with metastasis to the placenta is rarely described. We report a case of a large soft tissue sarcoma of the left neck...

link.springer.com
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PZM Diagnostics retweeted
Yale School of Medicine
@YaleMedJul 28
A person's inherited #genetics can strongly influence not only a person's risk of developing #cancer, but also how that cancer progresses, report researchers at @YaleCancer in a new @Nature study: bit.ly/4pJgMDS
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PZM Diagnostics retweeted
Science News@SciencNewsMay 19
Paternal Caffeine Exposure Programs Offspring Stress Vulnerability
Nutrition Science@NutrioSciApr 3
🎯Just Accept/The Innovation Nutrition Coffee and tea consumption in relation to chronic disease @HarvardHealth @Harvard @harvardmed @HarvardChanSPH Open Access doi.org/10.59717/j.xinn-nutr… #Nutrition #Meded #Medx #Coffee #Tea #Science #Health #Academic #PhD #PrecisionNutrition
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Science News@SciencNewsMay 8
Omega-3 supplementation may be associated with accelerated cognitive decline in older adults
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Talk to $ibrx and see if this qualifies a trial with a prayer !
60 Minutes
@60MinutesApr 24
Former Nebraska Sen. Ben Sasse was told he had months to live after he was diagnosed with pancreatic cancer in December. Sasse credits "providence, prayer, and a miracle drug" with extending his life. Watch Sasse's interview with Scott Pelley, Sunday on 60 Minutes.
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$ibrx IL15 is a natural product of human body and its use to correct lymphopenia is physiological. Many studies showed lymphopenia is associated with short survival of cancer. It’s reasonable to correct treatment induced lymphopenia without need to show it will prolong survival.
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$ibrx just like chemo induced leukopenia and #Neulasta. No need to show Neulasta actually prevent sepsis/severe bacterial infection because of #leukopenia. Similarly no need to show #epogen prolongs survival of anemic patients due to #hypoxia. This is the other side of argument.
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If #FDA approved IL15 for treatment of lymphopenia due to 1 condition, then it’s reasonable to use it for lymphopenia in all conditions. One drug for one disease. #epogen for anemia regardless due to chemo, infection or kidney issues. If expanded access, it’s approvable for all.
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$ibrx the value is to treat lymphopenia associated with cancer treatment. There are large data sets showing lymphopenia is associated with shorted survival in various cancers. #FDA wants data to show correcting lymphopenia can prolong survival. NMIPBC is just a rounding error.
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more replies
$ibrx There is only one current trial for expanded access for lymphopenia. It seems $ibrx thinks FDA is wrong on requiring more data in treatment related lymphopenia in all other cancer types, and $ibrx is not willing to provide the data. It’s an interesting, & unique scenario.
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A lot patients with cancer related lymphopenia will benefit from the drug, but the drug is narrowly approved and most patients won’t be able to get it. That’s really the most important issue. $ibrx should address this. To go after other big indications requires more resources.
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Preterm delivery and placental pathology with clinical and pathogenic implications | medRxiv medrxiv.org/content/10.64898…
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To do #RCT on every cancer to treat the same lymphopenia is probably unnecessary. What data to obtain depends on discussion with #FDA. $ibrx already has a lot of data on various cancers. When #lung cancer data published, it will add weight to discussion.
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Frontiers | T Cell Dysfunction and Exhaustion in Cancer $ibrx frontiersin.org/journals/cel…

Frontiers | T Cell Dysfunction and Exhaustion in Cancer

Tumor immunotherapy is a promising therapeutic strategy for patients with advanced cancers. T cells are key mediators of antitumor function, specifically rec...

frontiersin.org
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Clinical implications of T cell exhaustion for cancer immunotherapy | Nature Reviews Clinical Oncology $ibrx nature.com/articles/s41571-0…

Clinical implications of T cell exhaustion for cancer immunotherapy

Nature Reviews Clinical Oncology - T cells are key effectors of immunotherapies that have revolutionized the treatment of cancer; however, chronic exposure to tumour-associated antigens can result...

nature.com
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T-cell exhaustion: characteristics, causes and conversion - PMC. $ibrx pmc.ncbi.nlm.nih.gov/article…

T-cell exhaustion: characteristics, causes and conversion

T-cell exhaustion is characterized by the stepwise and progressive loss of T-cell functions and can culminate in the physical deletion of the responding cells. Exhaustion is well-defined during...

pmc.ncbi.nlm.nih.gov
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