Peptide Directory. Suppliers in the UK, US and AU, peptide information, and the research behind them. Informational only. Not medical advice. We sell nothing.
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Which peptides actually have research behind them? 🧬
We've summarised 164 research papers across 28 peptides, from large human trials to early mouse and cell studies, each labelled by study type and linked to the source.
Some highlights 🧵
Do GLP-1 drugs directly shrink muscle? 💪
In lab-grown muscle cells from older adults with obesity, semaglutide and GIP didn't trigger atrophy signals or block muscle-cell formation. Cell study only, but it fits lean-mass loss being indirect.
pubmed.ncbi.nlm.nih.gov/4298…
Does semaglutide lower blood pressure too? 🩺
A new meta-analysis of placebo-controlled trials (about 20,000 people) found systolic pressure fell by around 3.5 mmHg vs placebo, rated high-certainty evidence. The diastolic change was small.
pubmed.ncbi.nlm.nih.gov/4298…
Can a weekly GLP-1/glucagon peptide clear MASH liver inflammation? 🔬
In a 381-person phase 2b trial (Merck-sponsored), efinopegdutide resolved MASH in 56 to 63% vs 13% on placebo at 52 weeks. 7 mg looked best.
Abstract data, full paper to come.
clinicaltrials.gov/study/NCT…
Can a peptide help immunotherapy before cancer surgery? 🧬
In a single-arm phase 2 study, ruxotemitide injected into melanoma tumours alongside pembrolizumab met its goal of at least 40% complete response at surgery.
Company topline, not yet peer reviewed. Phase 3 planned.
Does semaglutide still help when kidneys struggle? 🩺
A new look at the FLOW trial (3,533 adults with type 2 diabetes and kidney disease) found lower HbA1c and weight vs placebo over 2 years at every stage of kidney function.
Post hoc analysis. Diabetes Obes Metab, 3 Nov
Could GLP-1 drugs change drinking? 🍷
In US records for adults with type 2 diabetes, starting semaglutide or tirzepatide was linked to about half the rate of alcohol-related hospital or ER visits vs SGLT2 drugs.
Observational, so a link only. Diabetes Obes Metab, 3 Nov
Every paper has a plain-English summary, the study type, who or what was studied (people, mice or cells) and a link to the original.
We sell nothing. Filter by peptide or study type here 👇
peptidefix.io/research
Can peptide-like molecules be built longer? 🧪
Chemists joined two short peptoid chains head to tail in water while keeping their enzyme-resistant backbone intact, a practical route to much longer peptoids.
Lab chemistry only. Biochemistry, 2 Nov
GLP-1s or SGLT2s for fatty liver plus heart failure? 🫀
In US records for 8,550 matched pairs, GLP-1 users had lower mortality (7.0% vs 10.1%) and fewer acute heart failure diagnoses.
Observational, so a link, not cause and effect. Balkan Med J, 2 Nov
Does semaglutide lower cardiovascular death? 🫀
A meta-analysis of 7 randomised trials (38,412 adults with diabetes, obesity or obesity-related HFpEF) found 17% lower risk of cardiovascular death vs placebo, consistent across groups.
Crit Pathw Cardiol, 2 Nov
Which GLP-1 does best on dialysis? 🩺
In US records for about 3,200 people with diabetes on haemodialysis, semaglutide was linked to lower 1-year mortality (11% vs 13%) and more weight loss than dulaglutide or liraglutide.
Observational study. Diabetes Care, 27 Oct
Could GLP-1 drugs help after a pacemaker? 🫀
In 3,609 people with type 2 diabetes, those on GLP-1 or SGLT2 drugs had lower 3-year mortality after implantation, with the combination doing best.
Observational, so it shows a link, not cause and effect. Curr Probl Cardiol, 1 Nov
Do insulin + GLP-1 combo shots beat insulin alone? 💉
A network meta-analysis of 30 trials (17,862 adults with type 2 diabetes) found every fixed-ratio combination lowered HbA1c and body weight more than basal insulin alone, often without extra hypoglycaemia.
Endocrine, 31 Oct
Can a peptide stop a virus fusing with cells? 🦠
S-880008, a lipid-tagged ring peptide from Shionogi, locks the COVID spike so it can't fuse. It worked across variants incl. Omicron, and given in the nose it cut viral levels and improved survival in mice.
Nature Comms, 28 Oct