@PeterLyLab

Genome Integrity Lab | Associate Professor @CRI_UTSW @UTSWMedCenter. We study how mitotic errors and genomic instability drive cancer evolution.

 Dallas, TX
thelylab.org
Joined October 2018
  • Tweets2.4K
  • Following620
  • Followers2.4K
103Media
When cells in different phases fuse, nuclei play a mitotic tug-of-war Olga Afonso, Daniel Feliciano and Jennifer Lippincott-Schwartz investigate the fate of syncytia containing nuclei at different cell cycle stages. Highlight: journals.biologists.com/jcs/…
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Our recent paper on CCAN organization was just out in @ScienceAdvances. We combined MD simulation with expansion microscopy to observe an interesting structure in the kinetochore. Congrats, @yj_sakai, Mariko, and @yasuhhirano17 !! Please check it out. science.org/doi/10.1126/scia…

CCAN forms the spherical shell-like structure in interphase kinetochores

The kinetochore is an essential structure for the faithful chromosome segregation during mitosis. The 16-protein complex known as the constitutive centromere-associated network (CCAN) localizes the...

science.org
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The Department of Biological Chemistry at UCI is seeking a tenure-track Assistant Professor! This is a broad search across biomedical sciences, including genome stability. Join a dynamic department with great faculty benefits and year-round sunshine! recruit.ap.uci.edu/JPF10441

Assistant Professor of Biomedical Sciences (tenure track)

University of California, Irvine is hiring. Apply now!

recruit.ap.uci.edu
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Out today in @JCellBiol Work from the Mogessie, @FachinettiLab & @DrSteffi labs reveals how CENP-A/B/C cooperate to maintain kinetochore function in oocytes and how declining centromere strength predisposes aging eggs to aneuploidy. @pewhealth @HFSP doi.org/10.1083/jcb.20260613…
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Peter Ly retweeted
Hao Zhu Lab@Zhu_LabOct 19
We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW
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Peter Ly retweeted
Anton Henssen@anton_ghOct 15
Happy to share our new study published this week in @NatureGenet 🔥🔥🔥🔥 nature.com/articles/s41588-0…

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

Nature Genetics - Single-micronucleus sequencing and live-cell imaging of cancer cells, as well as analyses of biopsies from patients with neuroblastoma, reveal that ecDNA in micronuclei limits...

nature.com
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That’s a wrap for FASEB Aneuploidy 2026! Thanks to all the attendees for making it a special meeting. The science was so out-of-this-world that NASA even launched a spaceship for us. 🚀 See you again in 2029! #ANESRC
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🔬TWO MORE WEEKS remain to apply for any of our three open faculty positions at cri.utsw.edu/careers #relentlessdiscovery

Careers - Children's Medical Center Research Institute (CRI) | Dallas Texas

Children’s Medical Center Research Institute at UT Southwestern (CRI) is a joint venture of UT Southwestern Medical Center and Children’s ...

cri.utsw.edu
Children’s Research Institute at UT Southwestern@CRI_UTSWAug 19
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
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Check out our latest, just out in @MolecularCell! We reveal how typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive cancer responses to PARP inhibitors—and propose that a similar synergy may contribute to A-T pathogenesis.
Molecular Cell@MolecularCellSep 28
Online Now: ATM safeguards DNA replication by restraining pathological repriming at endogenous base lesions dlvr.it/TVgxRM
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Peter Ly retweeted
Peter Ly@PeterLyLabAug 19
We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @CRI_UTSW is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!
Children’s Research Institute at UT Southwestern@CRI_UTSWAug 19
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
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😊 New preprint! In budding yeast, Dna2-intrinsic condensation regulates long-range DNA-end resection. Analyses suggest redistribution of condensate grammar in humans. Congrats to Chris Jordan and the Mekhail, Wyatt, Cowen & Hakem labs! More to come soon. biorxiv.org/content/10.64898…

Dna2-intrinsic condensation regulates DNA end resection and reveals evolutionary redistribution of...

Eukaryotic cells commonly use biomolecular condensation of DNA double-strand break (DSB) repair scaffolds and signaling assemblies to organize repair reactions in space and time. Yet whether DSB...

biorxiv.org
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Peter Ly retweeted
Yuan He@YuanHeJHUSep 22
A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.
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New Online! Mechanisms and disease relevance of DNA break repair pathway choice dlvr.it/TVXnnC
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How are mitotic chromosomes built? 🏗️ Our Review @TrendsGenetics revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwr…
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Peter Ly retweeted
Anton Henssen@anton_ghSep 14
Very happy to share our new Perspective in Nature Reviews Genetics, led and written primarily by my colleague Liam P. Shaw: “The shared evolutionary capacities of plasmids and extrachromosomal DNA” nature.com/articles/s41576-0…

The shared evolutionary capacities of plasmids and extrachromosomal DNA

Nature Reviews Genetics - Plasmids in bacteria and extrachromosomal DNA in cancer both generate copy-number variation, alter gene expression and promote rapid adaptation. In this Perspective, Shaw...

nature.com
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Excited to share our new @ScienceAdvances paper! During interphase, centromeres form 3D shells organized by the CENP-A chaperone complex at their core. Led by Hindol Gupta, with the @TakashiAkeraLab , Losada, and Shroff labs. science.org/doi/10.1126/scia…

The CENP-A chaperone complex spatially organizes centromeres

Centromeres, defined by CENP-A–containing nucleosomes, direct kinetochore assembly for spindle attachment. In mitosis, CENP-A and the constitutive centromere-associated network (CCAN) of the inner...

science.org
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🎉 Excited to share the first preprint from the Panday Lab! biorxiv.org/content/10.64898… We identify FANCM as an adaptive genome-maintenance dependency in BRCA1-deficient breast cancer and uncover its role in restraining ongoing structural genome evolution.

FANCM restrains structural genome evolution and defines a synthetic lethal dependency in BRCA1-de...

BRCA1 -deficient cancers experience persistent replication stress and structural genome instability yet retain the capacity for sustained proliferation, implying reliance on compensatory genome-mai...

biorxiv.org
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How did we come to understand cancer in the light of evolutionary theory? Nothing makes sense if not with population genetics! In our latest @NatureRevCancer review we unpack how population genetics theory applied to somatic cells allows us to measure and predict cancer evolution from molecular data. Computational modelling in oncology has gone a long way but we need to go much further. The frontier is combining evolutionary theory with machine learning. Link below👇
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