@PlathLab

Twitter feed for the laboratory of Prof. Kathrin Plath @UCLA

 Los Angeles, CA
plathlab.dgsom.ucla.edu/pages/
Joined June 2019
  • Tweets116
  • Following167
  • Followers948
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Excited to share our latest work: L126 fine-tunes enzymatic activity of histone H3, a discovery made possible by viewing the nucleosome as an enzyme. We have a gain-of-function mutant – it’s hard to enhance an activity if it doesn’t already exist! sciencedirect.com/science/ar…
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I'm delighted to have been mentioned in the celebratory article commemorating the 30th anniversary of NSMB #Xist_granules #phase_separation @tartaglialab @mitchguttman @PlathLab @NatureSMB nature.com/articles/s41594-0…
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Join us for this incredible @GordonConf on #StemCells and #Cancer in beautiful #Tuscany organized with @CedricBlanpain and @PlathLab!!🔬🧐🇮🇹
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I’m happy to share our new paper with @LabMomoko published today cell.com/stem-cell-reports/f… which examines how differences in the state of human stem cell pluripotency can lead to favorable or unfavorable outcomes when making brain organoids.

TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to...

Watanabe et al. show that hPSCs maintained under different conditions exhibit variabilities in the expression and function of TGFβ superfamily factors, which tracks with their state of pluripotency...

cell.com
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Plath Lab retweeted
Tracy Tran@TTdevbio7 Jul 2022
It’s finally out! Many thanks to my colleagues @jacksongcheng and my mentor Andy McMahon at USC for making this happen. #organoid #kidney #screen
USC Stem Cell@USCStemCell7 Jul 2022
In a @CellStemCell study, scientists from the @USCStemCell lab of Andy McMahon generated kidney-like structures called organoids, and used them to identify potential drugs for adult-onset polycystic kidney disease. @TTdevbio @jacksongcheng @KECKSchool_USC stemcell.keck.usc.edu/mini-k…

USC Stem Cell scientists use mini-kidney models to identify potential drugs for polycystic kidney...

Scientists from Andy McMahon's lab at USC generated kidney organoids, and used them to identify potential drugs for polycystic kidney disease.

stemcell.keck.usc.edu
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Happy to share our most recent paper (1/3): FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form primordial oocytes cell.com/stem-cell-reports/f…

FGFR3 is expressed by human primordial germ cells and is repressed after meiotic initiation to form...

Stem cell biology benefits from in vivo reference maps of human cell types to enable comparisons with human cells generated in vitro using stem cell differentiation. In this study, Chitiashvili and...

cell.com
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We are excited to host @DrPlattLab from @GeorgiaTech as part of our Scientific Excellence Through Diversity Seminar (SEDS) series. Join us Thursday, April 14th at 4pm in Boyer 159 for Dr. Platt’s seminar, which will be followed by a reception in the Boyer Hall Patio.
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Paper alert! 🥳🎉 Excited to share our latest study where we use genome-wide CRISPR screening to define the essential regulators and major impediments of reprogramming to human naive pluripotency - led by @Mandy_Collier and @bendall_adam science.org/doi/10.1126/scia… 1/13 🧵

Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human...

Genome-wide functional screening reveals new mechanistic principles that establish human naïve pluripotency.

science.org
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Plath Lab retweeted
Cell@CellCellPress9 Dec 2021
Out now! Instead of spreading across the X chromosome to inactivate it, Xist nucleates dynamic protein complexes, allowing protein expansion across the X to induce higher-order chromatin changes and gene silencing #sciencetwitter #xist @PlathLab @UCLA bit.ly/3oGHoHK
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We look forward to welcoming the stem cell community back in Vienna next year at #SYStem2022! Keynote speakers are Kathrin Plath @PlathLab and James Briscoe @briscoejames Find out more at ➡️sy-stem.org @IMPvienna @MaxPerutzLabs @viennabiocenter
Poster for the Sy-stem event

ALT Poster for the Sy-stem event

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We are recruiting a computational biologist to work on single-cell multi-omic datasets of reprogramming and/or brain cell types stemcell.ucla.edu/news/ucla-…

UCLA researchers awarded $4.7M NIH grant to study how genomic variation influences stem cell...

An interdisciplinary team of scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has received a $4.7 million award from the National Institutes of...

stemcell.ucla.edu
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SAVE THE DATE for our 9/28 Genetics Seminar from Dr. Kathrin Plath @BC_UCLA , presenting "A new mechanism for RNA-guided heterochromatin formation". Zoom info here: medicine.yale.edu/genetics/e… All @YaleMed affiliates welcome!
Headshot of Dr. Kathrin Plath at a desk

ALT Headshot of Dr. Kathrin Plath at a desk

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I'm pleased to announce and to have contributed to this new study from my colleagues Bill Lowry and @PlathLab. It's a great example of the collaborative work going on at @UCLAstemcell and @UCLA_BRI. cell.com/stem-cell-reports/f…

Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis

Plath, Lowry and colleagues profile interneurons generated from human pluripotent stem cells by various methods to understand the heterogeneity and cellular state of interneuron cultures in vitro....

cell.com
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Excited to announce our @genome_gov IGVF project to investigate the genetic regulation of reprogramming to pluripotency. Looking forward to collaborate with @PlathLab, Noah Zaitlen, @JasonErnstLab, @brunilda_balliu, @roy_wollman genome.gov/Funded-Programs-P… – at Los Angeles, CA
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New research has shown critical insight into how #CysticFibrosis alters the cellular makeup of airways, enabling scientists to better target the next generation of transformative therapies for patients. ceda.rs/3eoof8l
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Plath Lab retweeted
Will Tu@willtu223 Mar 2021
Excited to give a talk at @KeystoneSymp Metabolic Decisions in Development & Disease tomorrow! Looking forward to hearing some great science too. #VKSMetaDisease21
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WE WILL BE HOSTING A GRAD STUDENT PANEL TOMORROW 1/18 @5:30PM! Learn about the application/interview processes and grad school during the pandemic from various URM STEM PhD students - please share with anyone that could benefit! #UCLA #SACNAS 🐻🐻
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Learn How somatic niche and fetal germline stem cells are established during human testis development in this story! Congrats @JingtaoGuo and all the authors! Happy to be part of this work. cell.com/cell-stem-cell/full…
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NEW online by Amander Clark, @PlathLab & CO: Female #hPGCs display X-chromosome dosage compensation despite the absence of #Xinactivation. Download PDF: rdcu.be/cbD4m Comment by @CRougeulle: rdcu.be/cbD4j nature.com/articles/s41556-0…
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It was an honor and a pleasure to comment with ⁦@JeffOui94⁩ on this excellent work by ⁦@PlathLab⁩ and Amander Clark published in ⁦@NatureCellBio⁩ #Xinactivation nature.com/articles/s41556-0…
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