Enrico Gratton is one of the brightest minds I've known. His techniques literally changed my career path, and I am thrilled to have contributed to this humble tribute to his legacy, led by @VLeviLab link.springer.com/chapter/10…

Glad to have contributed to this review article discussing the complex interactive network among steroid receptors in breast cancer. Check it out! doi.org/10.1093/narcan/zcag0… @NAR_Cancer_EIC

(2/7) In this work, we investigate how GR translocates from the cytoplasm to the nucleus, using a fluorescence microscopy technique called pair correlation function (pCF)

🚨Pre-print alert!🚨 (1/7) Happy to share our latest work on glucocorticoid receptor (GR) biology, led by Cecilia De Rossi from @VLeviLab and @PresmanLab biorxiv.org/content/10.64898…

📷#SinLeyNoSePuede Sin la Ley de Presupuesto Universitario Nro. 27.795 sancionada el año pasado, no puedo enseñar microscopía de fluorescencia a mis estudiantes de Ciencias Biológicas.

📣Buscamos candidato/a para convocatoria 2026 de becas posdoc de CONICET 🔬Tema: Translocaciones de factores de transcripción y cofactores en cáncer. Lugar de trabajo: Facultad de Ciencias Exactas-Universidad de Buenos Aires ¡Escribimos!

In summary - GR is mostly dimeric upon ligand activation - GR’s final conformation might be a tetramer - GR-GR contacts depend on a complex, intertwined crosstalk within all structural domains: LBD, DBD, and likely the NTD - Is transrepression even necessary to explain GR action?

Finally, Eva and Pablo’s team was able to crystallize GR’s LBD in a tetrameric form, giving us a unique opportunity to probe and test different oligomerization surfaces on GR. They even managed to capture GR tetramers in vitro with a GR DBD-LBD fragment! doi.org/10.1093/nar/gkaf1003

By combining X-ray crystallography and live cell studies, @AlbaJimP1 and @Andrea_AlegreM were able to find new surfaces of GR-GR contacts, suggesting that several types of dimers can coexist in the cell doi.org/10.1093/nar/gkac1119

Back in 2016, we were able to quantify the oligomeric state of GR on a tandem array of DNA elements within live cells, and we were surprised to find that GR was actually a tetramer when bound to chromatin. doi.org/10.1073/pnas.1606774…

This paper marks the culmination of a 15-year (and 7 papers) journey to challenge #Glucocorticoid_Receptor (GR) dogma. The classic paradigm of GR action states that monomeric GR and dimeric GR regulate a different set of genes

Yo marcho para que otros/as puedan recibirse como yo pude hacerlo. Viva la Universidad Pública! #UniversidadPublica #NoAlVeto @Exactas_UBA