ROHAN CHANDRA DAS retweeted
Congratulations to Henri B. Kagan and Kenso Soai for the 2026 Nobel Prize in Chemistry, "for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis."
And this story has a boy from Pune in it....
Kagan's half began in 1986. He showed that a catalyst carrying only a small excess of one handedness can produce a product with a much larger excess. The small imbalance does not stay small.
Soai's half came in 1995: a reaction that makes more of itself, and prefers its own mirror image. By 2003 he reported a version that produced only one hand.
A tiny imbalance, amplified until one mirror image dominates. Extraordinary, and for about 25 years the machinery behind it resisted explanation. Many models were proposed. None stuck.
Then a boy from Pune decided the unexplained part was the only part worth doing.
Soumitra Athavale grew up in Pune, studied chemistry and biology at IISER Pune, and went to the University of Illinois in 2014 for a PhD in molecular and cell biology.
But he could not let the Soai mystery go. So he started cold emailing organic chemistry profs, asking to work on this one puzzle. Professor Scott Denmark met him, said yes, and found the money.
In 2020, Athavale was 1st author of the Nature Chemistry paper with Adam Simon, Kendall Houk and Denmark that gave the reaction the structural picture that stuck: a homochiral tetrameric catalyst, working almost like an enzyme, explaining the amplification the field had chased for a quarter century.
Denmark says students like Soumitra come along once or twice in an academic career.
The man who found the reaction is Japanese. The man who helped explain it was born in Pune.
Congratulations again to Kagan and Soai. And here is to Soumitra Athavale, the Indian who went looking for the mystery everyone else had learned to live with.
Happy to share our recent accounts on starin-release chemistry using BCBs published in Acc. Chem. Res. Thank you Sir for the support and Congratulations 👏 to SD @shiksha_deswal . Happy to be a part.
@ATBijuLab @ACSPublications @iiscbangalore
Happy😃to share our Accounts, just out in Acc. Chem. Res @ACSPublications on strain-release driven reactions of BCBs🦋! Nice summary by @shiksha_deswal & @RCD07_IISC👏👏. We thank @serbonline for the financial support🙏.
@iiscbangalore
pubs.acs.org/achre4/article-…
Congratulations Sir 🎉 for this Prestigious recognition. Your hard work and Discipline are the source of our motivation. Proud to be a part this group @ATBijuLab @iiscbangalore
ROHAN CHANDRA DAS retweeted
Just out @NatureComms, our work on visible-light mediated double strain-release Alder-ene reaction of BCBs🦋 with cyclohexynes to skipped dienes and remodeling to tetralines. Congrats @123shashankkk for nice work👏, funded by @serbonline👏!
@iiscbangalore
rdcu.be/TnJW5rg1pHKa
Happy to give the Thesis colloquium on
The day when i was successfully isolated and characterized.
It was really amazing to get the opportunity to present my research work in front of everyone in the department. Thank you Sir @ATBijuLab
For all the support always. Thank u all.
Rohan @RCD07_IISC presented his work on "NHC catalyzed imine umpolung, ketone activation and strain-release reactions using BCBs" in the Thesis Colloquium this afternoon.
Nice work and clear presentation, Rohan👏!
All our best wishes for your Thesis submission👍!
We can now perform the cross-coupling of electronically different BCBs🦋for selective access to cyclobutyl cyclobutenes, just out in @ACSCatalysis😃! Nice work by @deeptanu_2 & @KamalakshiB1103👏!
We thank @serbonline for funding 🙏!
@iiscbangalore
pubs.acs.org/accacs/article-…
Proud moment for our group... Congratulations 🎉 to both of you.
Back-2-back @JOC_OL 😉!
C-H Heteroarylation of aldehydes using NHC 🐈alysis by Subhashis & team👏!
pubs.acs.org/doi/10.1021/acs…
(3+3) Annulation BCBs🦋 with isothiocyanates for 3-aza BCHeps by Palash👏!
pubs.acs.org/doi/10.1021/acs…
We thank @ANRFIndia for funding🙏!
@iiscbangalore
ROHAN CHANDRA DAS retweeted
Just out @angew_chem, our work on NHC-catalyzed DKR of rotationally restricted cyclic imides to C─N and N─N axially chiral pyridinones.
Congratulations, @SowmyaShreeR2 & @AvishekDas01 👏
We thank MoE-STARS @EduMinOfIndia for funding 🙏
@iiscbangalore
onlinelibrary.wiley.com/doi/…
Happy to share our recent (inside) front cover page.
Our Tutorial Review on strain-release driven reactions of BCBs, recently published in @ChemSocRev has been Highlighted as the (inside) front cover of the latest issue.
Please see the review👉xlink.rsc.org/?DOI=D6CS00010…
Kudos to @shiksha_deswal & @RCD07_IISC
@iiscbangalore
Happy to share our work published in @green_rsc demonstrating greener mode of activation of BCB by protic ionic liquid. Excellent methodology developed by Palash and happy to be a part of this work. Thank you Sir @ATBijuLab for the support. @iiscbangalore.
📢just out @green_rsc,💚our work on use of protic ionic liquid serving as solvent, Brønsted acid, and reagent, enabling operationally simple & temperature-controlled BCB🦋activation😃. We thank @serbonline🙏for funding the work by Palash & @RCD07_IISC👏! pubs.rsc.org/en/content/arti…
Happy to share our work on a strain -release (of BCB) driven group transfer published in @ACSCatalysis . Thank you Sir @ATBijuLab for the support throughout. Also thank you Garima Ma'am @JindalLab for the DFT calculations. Congratulations to palash and Subhadeep. @iiscbangalore
Just out @ACSCatalysis, our work on strain-release Pudovik reaction for the diastereodivergent -OH transfer to BCBs using DPPO. Congratulations, @RCD07_IISC & team👏. We thank @JindalLab for the DFT studies👍 and @serbonline for funding🙏. @iiscbangalore pubs.acs.org/doi/10.1021/acs…
Happy to share our recent summary on strain -release driven reactions of BCB just out in @ChemSocRev . Many Congratulations 👏 to Shiksha @shiksha_deswal . Thank you Sir @ATBijuLab for your support throughout.
@iiscbangalore
Happy😃to share our Tutorial Review on strain-release driven reactions of bicyclobutanes, just out @ChemSocRev!
Congratulations, @shiksha_deswal & @RCD07_IISC for the timely summary👏. We thank @serbonline for funding our work on BCBs🙏! @iiscbangalore
pubs.rsc.org/en/content/arti…
ROHAN CHANDRA DAS retweeted
NHC catalysis is sustainable! Happy😃to share our (3+3) annulation to the selective synthesis of chiral quino(xa)linones, just out in ACS Sustainable Chem. & Engg.
We thank @EduMinOfIndia for funding 🙏, done by @SowmyaShreeR2 & team👏! @iiscbangalore
pubs.acs.org/doi/10.1021/acs…
ROHAN CHANDRA DAS retweeted
Happy😃to share the upcoming Thieme #Cheminar on "Strain-Release Chemistry".
Golden opportunity to hear @HariGroupIISc, @LcsoLab & @wipf_group
On Tuesday, February 24, 2026 ⏰3:30 PM to 6:00 PM (GMT+5:30)
👉 buff.ly/5WCuOFp. See you there!
ROHAN CHANDRA DAS retweeted
Just out @JOC_OL, our work on HFIP-mediated (3+2) annulation of BCBs with N-H indolyl alcohols for the diastereoselective synthesis of spiroindolenines😃!
Cool work by @shiksha_deswal 👏👏!
We thank @serbonline for financial support🙏!
@iiscbangalore
pubs.acs.org/doi/10.1021/acs…
ROHAN CHANDRA DAS retweeted
We can now access C-N & N-N axially chiral pyridinones via NHC-catalyzed DKR of rotationally restricted cyclic imides, preprint just out in @ChemRxiv! We thank @EduMinOfIndia for funding the work🙏, done by @SowmyaShreeR2 & @AvishekDas01
@iiscbangalore
go.shr.lc/4j9UrvW
ROHAN CHANDRA DAS retweeted
Happy 😃to share that two of our recent works have been highlighted in Oct issue of Synfacts. Indeed, one as the Synfact of the month👏!
pubs.acs.org/doi/10.1021/acs…; @JOC_OL
pubs.acs.org/doi/10.1021/acs…; @ACSCatalysis
Thank you @thiemechemistry for the highlight🙏!
@iiscbangalore
Many congratulations 👏 Palash and Shiksha.
The BCB with aryl group switches the selectivity from ene pdt to C═S insertion pdt in the reaction with thioindolinones for access to cyclobutanethiols, just out in @JOC_OL !
Thank U @serbonline🙏. Work by Palash & @shiksha_deswal👏!
pubs.acs.org/doi/10.1021/acs…
@iiscbangalore
ROHAN CHANDRA DAS retweeted
Excited to share our latest work on a one-pot annulation of vinyl sulfoxonium ylides with arynes, delivering rapid access to functionalized 1-naphthols! Check it out in @JOC_OL
Happy😃to share the Ru(II)-catalyzed annulation of vinyl sulfoxonium ylides with arynes for the synthesis of 1-naphthols, just out in @JOC_OL . Congrats @123shashankkk & @fathimadinsha3 👏for this nice work funded by @serbonline 🙏!
@iiscbangalore
pubs.acs.org/doi/10.1021/acs…
Comebacks always come after setbacks. An inspiring story.
“After two failed PhDs and nearly a decade lost, I was emotionally wrecked. My third PI helped me rebuild from the ground up.” @ami_jaganmoy
phdsofindia.medium.com/a-dec…































