Research laboratory @DartmouthChem utilizing structural biology, biochemistry and cell biology to investigate the molecular mechanisms of selective autophagy.
Joined July 2015
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Ragusa Lab retweeted
Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x
tinyurl.com/c7szhtfa
Ragusa Lab retweeted
It's known that anionic lipid charge enhances alpha-synuclein's ability to bind membranes. But did you know that alpha-synuclein can preferentially bind to neutral membranes when they are full of packing defects?
Read about it in our latest preprint!
Lipid Packing Defects are Necessary and Sufficient for Membrane Binding of alpha-Synuclein biorxiv.org/cgi/content/shor… #biorxiv_biophys
Ragusa Lab retweeted
Pleased to see our paper now published in Autophagy Reports!
Great work from all involved to discover more about how "protein ATG8ylation" works.
The big question is still "why?"
"ATG5 is dispensable for ATG8ylation of cellular proteins"
tandfonline.com/doi/full/10.…
Ragusa Lab retweeted
Come be my colleague! @DartmouthChem has an opening for an Associate/Full Professor in Materials Chemistry:
apply.interfolio.com/152869
Ragusa Lab retweeted
I am very happy our DFCP1 story is out! Since many years, DFCP1 has been used as an omegasome marker, but its function was totally unknown. Here we show that DFCP1 is an ATPase required for selective autophagy.
Here are the main points of the paper:
1/8
Ragusa Lab retweeted
Excited to announce that the Gonzalez Lab (chem-gonzalezlab.com) will open its doors when I join @DartmouthChem as an Assistant Professor of Chemistry in Fall 2023! (1/3)
Ragusa Lab retweeted
Very happy to see our paper now online. Great work from Wenxin, Taki and our fantastic colleagues #autophagy #crick @wencyzh @Sci_Lipi
doi.org/10.7554/eLife.89185 @eLife
Ragusa Lab retweeted
Have a Ph.D. in organic chemistry but want to gain experience applying data science to reaction development? The Read Lab @DartmouthChem is hiring a postdoc! See readlaboratory.com for more info. Please RT. #chempostdoc
Ragusa Lab retweeted
Our paper is out! Congratulations to @Cassandra_Hayne @TheHayneLab @RobinStanleyLab at @NIEHS ! I had fun image processing this project! nature.com/articles/s41594-0…
Ragusa Lab retweeted
Super excited to share a review article by @Nguyen_T_Hieu and myself on Substrate and phosphorylation site selection by PPPs! sciencedirect.com/science/ar…
Ragusa Lab retweeted
.@tjolivas, Yumei Wu, @shenliang_yu, @TJ_MeliaLab et al. @YaleCellBio show that ATG9 vesicles are the membrane seed for mammalian autophagosomes using nanodisc technology bit.ly/3LBlFg4
@PDClab
@GuptaLab1
@1in_1uan
@em_guinn
@ShantaNag1
#autophagy
Ragusa Lab retweeted
Here is the upated article from our lab, published today. Great job @DabrowskiRahel and @susanna_tulli !
🚨 I’m thrilled to announce that my PhD paper has just been published in @JCellBiol🥳🚨
We find that parallel phospholipid transfer by Vps13 and Atg2 determines the dynamics of autophagosome biogenesis 🍩
#Autophagy @GraefLab @UniCologne @Wautophagy
rupress.org/jcb/article/222/…
1/8
Ragusa Lab retweeted
🚨 Thesis Seminar Alert: Daniel Walsh (Supattapone Lab) will present his research today at 11am in Chilcott and on Zoom!
Daniel Walsh will be delivering his PhD Thesis Presentation TODAY at 11:00 am. Join us in Chilcott Auditorium or online via Zoom.
geiselmed.dartmouth.edu/bioc…
Ragusa Lab retweeted
Excellent! preprint from @RangamaniUCSD and @ibudin show new roles for mitochondrial lipids in inner mitochondrial membrane morphology
Cristae formation is a mechanical buckling event controlled by the inner membrane lipidome biorxiv.org/content/10.1101/…
Ragusa Lab retweeted
We are thrilled to announce the launch of our "Proof is in the Pudding" Seminar series with an inaugural seminar by Dr. Chantell Evans, PhD. Special thanks to the Department of Biochemistry & Cell Biology (@DartmouthBCB) for co-sponsoring this seminar.
Ragusa Lab retweeted
I'm excited to share that the Landino Lab will officially open this summer at at Dartmouth Geisel School of Medicine in @DartmouthBCB We will investigate cytoskeletal dynamics and cell division using Xenopus 🐸 We're recruiting at all levels - please share!
Ragusa Lab retweeted
This is huge! American Cancer Society post-doc fellowships now open to all post-docs in the US (with appropriate visa) regardless of citizenship status. Fantastic move from this great organization in its support of trainees and science.
cancer.org/research/we-fund-…
Ragusa Lab retweeted
First transatlantic preprint from the @GraefLab! We found that Atg2 cooperates with Vps13 to channel phospholipids into autophagosome membranes during #autophagy. Very proud of the work from @DabrowskiRahel and @susanna_tulli!
biorxiv.org/content/10.1101/…
