@RandauLab

Our laboratory studies Class I CRISPR-Cas biology and archaeal RNA processing pathways at the Philipps-Universität Marburg @Uni_MR. All views are our own.

Joined April 2022
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We have two postdoc positions available (funded for 3 years by Volkswagen Momentum) for research related to the de novo evolution of (i) bacterial anti-CRISPR activities and (ii) archaeal tRNA gene introns. Please feel free to share or apply: stellenangebote.uni-marburg.…
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Thank you for the detailled overview of this team effort and your hard work @patrick_pausch! If you want to see beautiful Type IV effector complexes in action, check out: nature.com/articles/s41467-0…

Structural variation of types IV-A1- and IV-A3-mediated CRISPR interference

Nature Communications - Type IV-A CRISPR-Cas systems diverge from the general CRISPR-Cas mechanism. To understand this system, the authors determine cryo-EM structures of two evolutionarily...

nature.com
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Happy to share our paper on archaeal mRNA caps and their processing in @NatureComms: rdcu.be/drIXx Thank you very much to our very helpful partners in the labs of @JaeschkeLab, @HoerferLab, Jörg Soppa and Nicole Paczia. @Bio_UM, @SYNMIKRO
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Our lab has an open #Phdposition for students interested in RNA and Archaea: stellenangebote.uni-marburg.… Please feel free to share if you know (or are :-)) a good candidate.
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Thank you for the organization. It was fun to learn about company perspectives.
GBM e.V.@GBM_eV1 Dec 2022
Replying to @RandauLab
@RandauLab on „The diversity of non-coding RNA functions“
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Thank you very much to @petergm24 lab and everybody involved! If you would like to read about how Type IV #CRISPR regulates host gene expression @NatureMicrobiol, please feel free to follow this SharedIt link: rdcu.be/cWBfW
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Great story and we were happy to help a bit with the snoRNA-seq part: Emergence of the primordial pre-60S from the 90S pre-ribosome: Cell Reports cell.com/cell-reports/fullte…

Emergence of the primordial pre-60S from the 90S pre-ribosome

Ismail et al. report the isolation of a primordial pre-60S particle, composed of a specific set of assembly factors and snoRNAs. This assembly intermediate is visualized by cryo-EM while emerging...

cell.com
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