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Happy (and proud) to share EarlyFMT is now published in @Lancetgashep!
#FMT after vancomycin outperforms vancomycin alone for 1st or 2nd #Cdiff infection!
90% FMT vs 33% vancomycin alone.
Our thoughts behind the trial journey that started 5 years ago?
thelancet.com/journals/langa…
Simon MD Baunwall retweeted
New online - International consensus statement on microbiome testing in clinical practice
thelancet.com/journals/langa…
#GITwitter #microbiome @gianluca1aniro
Simon MD Baunwall retweeted
Our Consensus statement on #microbiome testing in clinical practice is out in @LancetGastroHep! authors.elsevier.com/a/1kDP5… Here we recommend how to standardise the framework for test release (indications, pre-testing protocols, sequencing & analysis, result reporting). A thread🧵⬇️
Simon MD Baunwall retweeted
Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study hubs.li/Q02ZHSVm0
ALT Research in context panel. Copyright: 2024 Elsevier Ltd. All rights are reserved.
Simon MD Baunwall retweeted
My favourite paper published in
@AGA_Gastro in 2023 is shorturl.at/uBDJN
Raygoza and colleagues show for the first time that changes in the gut microbiota precede Crohn's disease onset by up to five years , supporting a causal role of gut microbiome alterations in IBD.
Simon MD Baunwall retweeted
An early Christmas 🎁 from @HepGas and the first paper from @DaugaardAC and my PhD!
Experimental #MASLD induces 🧠 dysfunction through systemic inflsmmation in early stages. An important mechanism also in patients?
@ISHENliver @tnu_au_dk
🟪 NEW Article in press❕
Cognitive dysfunction in early experimental non-alcoholic fatty liver disease is associated with systemic and neuroinflammation
🔓#OpenAccess at 👉 jhep-reports.eu/article/S258…
#LiverTwitter
#NAFLD
Simon MD Baunwall retweeted
Call for papers related to
"Helicobacter pylori infection"
▶️original research investigating the pathophysiology, diagnosis or treatment of Helicobacter infection
nature.com/collections/hddea…
@SciReports
Maybe it’s time to reconsider that a “FMT treatment” is not just a single administration, but rather a treatment sequence of multiple administrations?
#UEGWeek #UEGWeek2023 @marcellofiorani has presented our results of #FMT in a large cohort of patients with severe CDI. Sequential is better! #microbiomeclinicians
Simon MD Baunwall retweeted
#UEGWeek #UEGWeek2023 @marcellofiorani has presented our results of #FMT in a large cohort of patients with severe CDI. Sequential is better! #microbiomeclinicians
Simon MD Baunwall retweeted
#UEGWeek #UEGWeek2023 today @deborarondine03 has presented the results of our #FMT donor screening program based on direct molecular testing of each stool batch for intestinal pathogens and MDRO. Tough but safe. #microbiome #microbiomeclinicians
Simon MD Baunwall retweeted
Great insights by @ChristianHvas on regulatory and legal issues related to FMT in Europe! From #SoHo- substance of human origin to EDQM guide #uegweek23
Simon MD Baunwall retweeted
Join our official #EurFMT Common Interest Group meeting #UEGweek23 15.10.2023 at 14:00 Room 5 in person only!
We look forward to welcoming our current and future network members for interaction!
Simon MD Baunwall retweeted
In the review, "Small intestine vs. colon ecology and physiology: Why it matters in probiotic administration", @TeamBenLab et al. unfold differences between the small and large intestine of importance for gut microbiota manipulation at defined locations👍
pubmed.ncbi.nlm.nih.gov/3768…
ALT Figure 1. Anatomy and physiology of the small intestine (SI) versus colon.
Simon MD Baunwall retweeted
Thanks to @ChristianHvas for providing a deep dive into the challenges and performance issues related to FMT protocols!
@EurFMT at #EHMSG2023
Simon MD Baunwall retweeted
FMT session @ehmsg 2023, kicking off Prof Keller covering FMT beyond c.diff. @JKupcinskasLT @alinkmd @h_sokol @gianluca1aniro @AnnemiekeSmet @ChristianHvas #Microbiology #microbiome
Simon MD Baunwall retweeted
In all my years of #FMT practice, I have never had a situation where I regretted having performed an FMT, ...but there are still individual cases where I do regret not having performed an FMT earlier!
Can the effect of FMT for recurrent CDI be optimized?
We tried. It was not easy.
Overall, we did reach a 91% following multiple FMT, but only 69% from a single FMT.
A small 🧵1/5
onlinelibrary.wiley.com/doi/… @APandT @ChristianHvas @EurFmt
4/5 When we repeated the FMT, we observed the following outcomes:
... indicating that if FMT does not work initially, then it could be repeated with good effect.
