I am interested in virus-associated cancers, notably Burkitt Lymphoma and Kaposi sarcoma. Both are common in Africa. These are personal views.
Joined March 2019
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Delighted to share our article confirming that the aggressive pediatric 11q Large B cell lymphoma occurs in Africa. Molecular tests are needed to resolve this case from Burkitt. pubmed.ncbi.nlm.nih.gov/4291…
Burkitt Lymphoma: Current Understanding, Unmet Needs, and Research Directions - we are delighted to share our review on the outstanding progress made in BL research, the persistent disparities in care and survival, and opportunities for new research. pubmed.ncbi.nlm.nih.gov/4244…
The Complex Interplay of Malaria and EBV in Burkitt Lymphoma posits that EBV and malaria mutually cooperate to confer survival advantage against severe malaria, efficient transmission of both pathogens, with BL as an accidental outcome of the mutualism. mdpi.com/2072-6694/18/13/214…
Sam M Mbulaiteye retweeted
Selective Immune Tolerance: A Unifying Mechanism Linking Heavy Malaria Exposure, Waning Vaccine Antibodies, and Burkitt Lymphoma
✅ Just Accepted
✍️ @smbulaiteye
🔗 bit.ly/4uWfM0e
We are were intrigued by low anti-tetanus toxoid antibodies in children with Burkitt Lymphoma. The study by Sbarra suggests that heavy malaria causes antibodies to wane. We suggest that is an adaptive response to survive heavy malaria. pubmed.ncbi.nlm.nih.gov/4231…
nature.com/articles/s41591-0…. Pleased to share this landmark article showing potential to use blood-based genomics tests for faster diagnosis of Burkitt lymphoma in African children. Congs @AnnaSchuh3 and team, @UniofOxford, @NCIDirector , and DCEG, & @NIHRresearch. Please read share.
Faster, simpler, and accurate methods of diagnosing Burkitt lymphoma are needed. We show that Circulating plasma EBV DNA: a potential tool to facilitate diagnosis of pediatric Burkitt lymphoma in sub-Saharan Africa. Earlier diagnosis of BL is possible. sciencedirect.com/science/ar…
Super excited to share our paper “A genome-wide association study identifies an African-specific locus on chromosome 21q22.12 associated with Burkitt lymphoma risk and survival”. This work should encourage more studies to understand the genetic basis of BL nature.com/articles/s41375-0…
Joint analysis of Burkitt tumors from Africa, US, Europe, and Latin America continents confirm confirms DNA methylation epitypes of Burkitt lymphoma with distinct molecular and clinical features. Regardless of geography. pubmed.ncbi.nlm.nih.gov/4033…
Diagnosing Burkitt Lymphoma in Sub-Saharan Africa by Sequencing of Circulating Tumor DNA: A Comparative Microcostin… pubmed.ncbi.nlm.nih.gov/4020… Dr. Morrell shows that liquid biopsy is feasible for Burkitt lymphoma diagnosis, but we need to increase scale #diagnoseallBLcases #AIREAL
Subtyping Burkitt Lymphoma by DNA Methylation - by studying Burkitt tumors from Europe and Africa together, we confirm that EBV is the major driver of biological variation in BL, and discover additional variation in both EBV positive and negative BL. pubmed.ncbi.nlm.nih.gov/4019…
Sam M Mbulaiteye retweeted
I am delighted to share our work identifying excess cancer risk among Asian American and Pacific Islander solid organ transplant recipients. I appreciate @JNCI_Now and contributions from my coauthors! academic.oup.com/jnci/articl…
CIFF2025 - BURKITT | Solas Nua I enjoyed seeing this documentary, which tells Burkitt’s story of discovery of his eponymous disease. Careful observation, enquiring mind, and sharing results with passion opened up the field of viral oncology! Asante Sana! solasnua.org/events/ciff2025…
Sam M Mbulaiteye retweeted
Happy to share our paper in @NatureComms with Oscar Florez-Vargas @oflorezvargas and team! We explore a VNTR as a functional GWAS lead for bladder and many other cancers, and show mechanism in cancer, telomere length, and longevity nature.com/articles/s41467-0…
We need more such stories in African patients with Burkitt lymphoma!
Overjoyed because I overcame cancer 😂 🩷
#burkittlymphoma #cancersurvivor #Lacorhospital
Full story 👇
lacorhospital.org/a-happy-en…
