@sebroemer.bsky.social Clinician Scientist at Franzmeier-Lab ISD; Resident Physician in Neurology at LMU Munich; Max Planck School of Cognition PhD
München, Bayern
Joined February 2013
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- Following225
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Sebastian Roemer-Cassiano retweeted
1/11 Our new paper is out in Alzheimer’s & Dementia! 🚨
Does cortical excitation–inhibition (E/I) imbalance link amyloid pathophysiology to memory? We tested this in non-demented older adults (cognitively normal + MCI) across two independent cohorts. 🧵👇
doi.org/10.1002/alz.71891
Sebastian Roemer-Cassiano retweeted
Out now in Brain: Our new study co-led by @matbrendel shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/artic…
Sebastian Roemer-Cassiano retweeted
Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s00259-025-0…
Sebastian Roemer-Cassiano retweeted
Happy to share new work by Carla Palleis in @movedisorder, showing that brain networks route neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP
doi.org/10.1002/mds.30257
Sebastian Roemer-Cassiano retweeted
So excited and honored to be invited to present the opening plenary at #AIC2025 this year in Toronto! 🧠
🙏 I would be very grateful if you could help me gather the most inspiring papers (including your own!) of the past year by completing this survey: alz.surveymonkey.com/r/923BT…
🚨Calling all neuroimagers! Help @EmmaCoomans shape the opening plenary at #AIC2025 (Toronto, July 26th) "Accomplishments of the Past Year" and share the most impactful neuroimaging research from the past year via this brief survey (~5min) by May 30th.
act.alz.org/site/R?i=eOejFv9…
Sebastian Roemer-Cassiano retweeted
Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.
doi.org/10.1186/s13024-025-0…
Sebastian Roemer-Cassiano retweeted
de Bruin et al. report that traumatic brain injury alters amyloid-β and tau deposition, with increased accumulation in fronto-parietal regions, & disrupts amyloid-tau coupling. Please read at: buff.ly/437ElwX @deBruin_Hannah @Colin__Groot @RikOssenkoppele @nfranzme
Sebastian Roemer-Cassiano retweeted
What’s the relationship between #AmyloidBeta and tau protein?
New research involving #AlzheimersDisease patient PET and fMRI data reveals amyloid-beta may drive tau spread through hyperconnectivity between vulnerable brain regions. @nfranzme @SebRoemer scim.ag/3CfY6aR
Sebastian Roemer-Cassiano retweeted
This week's issue of #ScienceTranslationalMedicine is out now!
A new transplant protocol extends the survival of heart transplants in large animals, researchers explore emerging horizons in the use of hypoxia to treat chronic conditions, and more. scim.ag/3EiZjhW
Sebastian Roemer-Cassiano retweeted
Always my favourite post at the beginning of the year:
Registration for our course “Biomarkers for neurodegenerative diseases” is now open!
This year’s edition takes place at @UCLIoN in central London on May 12-16.
biomarker-course.org
Sebastian Roemer-Cassiano retweeted
Happy to share our new preprint led by @JGnorich and @matbrendel, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques
medrxiv.org/content/10.1101/…
Sebastian Roemer-Cassiano retweeted
Happy to share @davinabiel newest in @EmboMolMed showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women
Many thanks also to @matbrendel! doi.org/10.1038/s44321-024-0…
Sebastian Roemer-Cassiano retweeted
Paper alert: We performed a prognostic validation of the MDS PSP criteria, showing most patients with possible/suggestive PSP show an increase in diagnostic certainty over time. Increase in diagnostic certainty could be used as an endpoint in trials
doi.org/10.1002/mds.30112
Sebastian Roemer-Cassiano retweeted
Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP doi.org/10.1007/s00401-024-0…
Sebastian Roemer-Cassiano retweeted
Check out the latest update on our study! We dive into the nuances of the tradeoff between scan time and sample size in BWAS analyses. A special thanks to all the coauthors who contributed their datasets to make this possible!
Super excited about our revised study! 4 more datasets showing robustness across fMRI sequences, racial groups, disorders, lifespan, phenotypic domains & resting/task FC: doi.org/10.1101/2024.02.16.5…
@Leon_Oo1 @ZShaoshi @csabaorban broke the lab's record with a 76-page response!
Sebastian Roemer-Cassiano retweeted
Looking for a fully funded PhD program? Cognition is something you relate to? Check out our excellent offer for international applicants: cognition.maxplanckschools.o… #maxplanckschools #passionforscience 🧠🧠🧠
Sebastian Roemer-Cassiano retweeted
Biological definition of Parkinson’s disease is approaching 🚀 will this be „ATN“ for PD? much to do for the neuroimaging community! Many thanks to @SilviaMorbelli @ProfNAlbert @GunterHoglinger and the EANM NIC!
link.springer.com/article/10…
Sebastian Roemer-Cassiano retweeted
New Paper alert doi.org/10.1002/mds.29866: We compared MRI measures (volumetric/planimetric/staging systems) to track atrophy in PSP. Brainstem/midbrain volume tracked atrophy progression best, suggesting usability as surrogate endpoints.
@GunterHoglinger @RoemerSeb @johanneslevin
Sebastian Roemer-Cassiano retweeted
First autopsy validation of PET tracer PI-2620 in #progressivesupranuclearpalsy confirms it binds 4R tau deposits. @LMU_Muenchen ow.ly/FJkn50RTzmP
Sebastian Roemer-Cassiano retweeted
Day 1 was already amazing!! What an impressive line-up of speakers, and what a great group of smart and eager participants. Can't wait for the rest!
