Cheetham Lab @AIBNatUQ |Director @NationalBiolog2 | ARC Future Fellow | #mRNA drug discovery | https://xitter.cf/t.co/UCsRaX8MG2
Brisbane, Queensland
Joined July 2017
- Tweets799
- Following1.3K
- Followers1.7K
- Likes1.2K
Pinned Tweet
The greatest challenge for #mRNA-LNP therapies is targeting non-liver tissues. To overcome this, we used customisable bispecific antibodies to tether mRNA-LNPs to cell-surface proteins, achieving efficient and selective mRNA delivery in vivo. @BASEmRNA
biorxiv.org/content/10.1101/…
To accelerate #mRNA vaccine and therapy research, I'm excited to share our end-to-end protocol for #mRNA design, synthesis and encapsulation in
@NatureProtocols.
Protocol development by @LauraJLeighton, Natasha Chaudhary and Tim Mercer. @BASEmRNA
nature.com/articles/s41596-0…
A huge milestone for personalised #mRNA therapeutics for inherited disease! A baby with an ultra-rare mitochondrial disease was treated at UPenn with an mRNA-encoded gene-corrector. The mRNA was made to treat a single individual in just 7 months!
nejm.org/doi/full/10.1056/NE…
Systemic mRNA-LNP delivery beyond the liver? Check out our recent paper demonstrating cell-specific mRNA-LNP delivery using PEG- and target cell-specific antibodies. This approach can customised to any target cell-type with off-the-shelf mRNA-LNPs. 1/
sciencedirect.com/science/ar…
The technology is programmable and works with other targeting arms including anti-PSMA (highly expressed on prostate cancer cells) bispecifics.
Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc Laura Leighton found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics.
biorxiv.org/content/10.1101/…
Interested in undertaking a #PhD in the transformative field of #mRNA cancer vaccines? I have an earmarked PhD #scholarship available for an outstanding domestic student to join our team at @UQ_News and @BASEmRNA . If this sounds like you, get in touch.
study.uq.edu.au/study-option…
Seth Cheetham retweeted
Opportunity for a bioinformatician to join the lab @PeterMacRes to help us identify new Immunotherapies. Please reach out for further details. Ad is for a post doc but research assistants considered. 💻 🧬. See link below.
Wow this is super cool! Single-cell resolution imaging of
#mRNA-LNP biodistribution in cleared mouse bodies.
nature.com/articles/s41587-0…
Exciting news! @BASEmRNA and Vaxxas have been awarded the $2M USD Biomedical Advanced Research and Development Authority (BARDA) Patch Forward Concept Stage Prize to develop thermostable needle-free mRNA vaccines! @AIBNatUQ
uq.edu.au/news/article/2025/…
It was fantastic collaborate with @Fer_NK_nando on this programme to develop CAR-NK therapies for sarcoma with #mRNA tech. These mRNA-enhanced NK cells can eliminate cancer cells in vitro and in vivo. Out now in Clinical and Translational Medicine. @TRI_info @AIBNatUQ @BASEmRNA
This Post is from an account that no longer exists. Learn more
Awesome work from @MJMitchell_Lab at UPenn in @Nature identifies novel LNPs that can deliver #mRNA to the placenta. Using the placenta-targeting LNPs to deliver VEGF mRNA improves pre-eclampsia in animal models.
nature.com/articles/s41586-0…
Earlier this year I had the opportunity to present a TEDx talk on the transformative potential of personalised
#mRNA vaccines for cancer. The recording is out now: youtube.com/watch?v=BnSOgJab…
@AIBNatUQ @BASEmRNA @UQ_News
There are more ways to design an mRNA than atoms in the universe, so how do you choose the best one? Our new @BASEmRNA software, mRNArchitect enables you to tune expression, stability, reactogenicity and synthesisability to design more potent #mRNA drugs
biorxiv.org/content/10.1101/…
Work led by Helen Gunter @Mercerlab1, @AIBNatUQ @TRI_info @UQ_News
Try it out here:
basefacility.org.au/software…
We're building Australia's first centre for the designing and manufacturing personalised cancer vaccines @BASEmRNA @AIBNatUQ. On the PhaseIII podcast I discuss the transformative potential of mRNA for cancer and our efforts to bring this tech to patients
podcasts.apple.com/au/podcas…
