I am pleased to announce our first P50 Center hybrid seminar by Dr. Shiro Horisawa from @TWMU_function on “Surgery at Forel’s Field for #MovementDisorders and Beyond”. Join us on May 8th, 4-5 pm EDT, virtually or in person, if you are in Boston area.

Very exciting presentation by @Maitreyee_W with an amazing advance toward real-time synthesis of continuous speech from neural signal in premotor 6v cortex 👏👏👏 The door to endless possibilities in speech rehabilitation & treatment! @sergeydoestweet @DrDavidBrandman #BCImeeting

Very engaging poster session and presentation by @ehrlich_sk on #BCI for treatment of focal #dystonia at #BCImeeting @BciSociety @dmrf

we developed & tested a deep-learning platform #DystoniaBoTXNet to automatically determine the #BotulinumToxin treatment efficacy. Based on structural brain MRI, DystoniaBoTXNet discovered treatment #marker & achieves 96.3% accuracy in 19.2 sec in predicting injection efficacy.

Very excited & proud of the @SimonyanLab team for developing the first #BCI (brain-computer interface) for patients w laryngeal #dystonia and starting this one-of-a-kind clinical trial bit.ly/3N7RYBk! Grateful to @NIDCD for funding. Follow us for updates & participation!

Pathophysiology involves widespread alterations of neural network function and structure, abnormal dopaminergic and GABAergic function, & maladaptive plasticity. Alterations of premotor-parietal regions are of critical importance being influenced by external and polygenic risks.

Genetic & extrinsic risk factors may trigger symptoms of laryngeal #dystonia in susceptible individuals. Understanding genetic/extrinsic risk interplay with neural changes may lead to novel preventive approaches.

Laryngeal #dystonia diagnosis is challenging & may extend over 5 years. Clinical assessment should include a detailed case history, auditory-perceptual testing, nasoendoscopy & neuro exam. The highest priority is the development & implementation of accurate diagnostic biomarkers.

Patients with generalized #dystonia reported the highest #suicide (50%), followed by 46% in patients with multifocal/ segmental dystonia and 33.3% in patients with focal dystonia. The highest suicidal ideation-to-attempt ratio of 4:1 was in generalized dystonia.

Based on objective microstructural biomarker and using raw structural MRI, DystoniaNet achives 98.8% accuracy in diagnosing laryngeal dystonia, cervical dystonia and blepharospasm, while referring 3.5% of cases for further examination. The speed of diagnosis is 0.36 sec!