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I challenge the "things have literally never been better" crowd to reflect on some of these. 1/4
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Eli Lilly's pipeline is out of control:
Q3 just dropped:
- retatrutide: ~28% body weight lost at 80 weeks, up to 30% at 2 years in the extension (phase 3, not approved yet)
- retatrutide vs ozempic's top dose in type 2 diabetes: more than 2x the weight loss
- foundayo, the weight loss pill: $184m in its launch quarter
- elora + tirzepatide beat tirzepatide's top dose in phase 2. phase 3 starts this quarter
- a once-weekly insulin got fda approved
- mounjaro is now approved to cut heart risk
- olumiant approved for kids 12+ with severe alopecia areata
- $24.4b revenue in one quarter, up 39%
what's coming:
- retatrutide trials in heart disease, knee osteoarthritis and sleep apnea
- olomorasib, a KRAS lung cancer drug, with durable first-line data
- a next-gen ADC for ovarian cancer, first human data just shown
- in vivo car-t, from the kelonia acquisition
- one-time gene editing for high cholesterol, from the verve acquisition
the number that matters: volume up 53%, price down 15%
my take is that obesity is now the cash machine, and lilly is spending it on everything else: gene editing, cell therapy, cancer.
the weight loss boom is paying for the next wave of drugs
bio/acc
Meanwhile, others are complaining about vALuaTioNs of the cybersecurity names. These people hate making money.
# Black October
For anyone who knows me even somewhat well, it's clear that I am a 99th percentile tech optimist. However, the vibes have shifted for me quite a bit in the last 18 hours, and I feel a moral imperative to share what I'm thinking and feeling with my circles so that everyone can understand, and hopefully take seriously, what's happening right now. I think October 2026 will have many chapters written about it in the history books.
You know those scenes in financial movies like Margin Call where someone realizes that they're all fucked, and no one else sees it yet? And that person feels like they're crazy, and then suddenly everyone is pulling an all-nighter in a boardroom and freaking out? Yeah, that's kind of how this is feeling right now in the SF/Bay Area/AI circles.
We're 48 hours into what is being called Black October. In the last 2 days there have been several dozen cyber attacks which, in isolation, would each have been the worst to happen in an entire calendar year. Every sector from government to education to big tech and banks is being massively affected, and people are starting to freak out.
In a nutshell, what's happened is that frontier AI models have gotten to a point where they are as advanced as the most sophisticated programmers, with one critical difference: they can work 24/7, and you can spin up 10,000 of them with a single command and they'll work together tirelessly until they accomplish their task. The most advanced models today are from companies like Anthropic and OpenAI, whose current best technology is so good that they haven't been able to roll it out to everyone yet because of the national security risks it poses.
Meanwhile, the best open source models (where anyone can just download the model weights and do whatever they want with them, uncensored) are slightly behind the frontier but still 90-95% as capable. These models, developed primarily in China, are being used by black hat hackers to wreak havoc on the Western capitalist structure. Presumably, this has been part of China's plan the entire time, and we're seeing its implications fall out in real time.
In red-pilled AI circles, we've been sharing and reading papers called things like "Situational Awareness" and "AI 2027" for the last year or so, which at the time felt a bit like near-term speculative fiction. They laid out the case for why Artificial General Intelligence (AI smarter than any human at any knowledge task) and Recursive Self-Improvement (models that are able to use themselves to get better) weren't half-baked future ideas anymore, but instead an inevitable outcome of the linear progress that's happening.
These papers would then talk about things like "takeoff scenarios," trying to envision how that moment would come to be and what it would be like when it happened. It would either be a "slow takeoff" that would play out over the course of months and quarters, happening subtly and only obvious to a few. Or, it would be a "fast takeoff" where it would pretty much happen instantly, like a bit flipping from 0 to 1.
From everything that I can see and am feeling, we are currently experiencing the fast takeoff scenario. Beyond the crazy security vulnerabilities that have come out recently, there have also been massive breakthroughs in life sciences, fundamental computer science, materials science, and pure mathematics that have all landed in the same time frame. While I still firmly believe that AI will be a net positive for humanity, it's more clear to me than ever that the societal and individual risk is very real, and is playing out NOW.
For as much conviction as I have that this is happening, the thing that's caused me to lose sleep is that I don't really know what to do about it, or more importantly, what to tell you, reader, to do about it. So, the best I can do is make a few suggestions that have always been a good idea but are more timely now than ever:
Set up 2-factor authentication for everything. I use Duo.
Use a password manager across your devices. I use 1Password.
Get an identity protection app set up. I use Alta.
Move your IoT devices to their own network. Claude helped me do this.
And last, but certainly not least, if you've been avoiding leaning into AI, see this as a catalyst to wake up and start using it. Don't just use the chat mode version of ChatGPT/Claude; click that Code/Work button and see how easily you can have AI write code to help you with your job. One of the biggest vulnerabilities was in a massively popular programming language called PHP, and the prompt that set it off was literally, "Find vulnerabilities in php."
This is an unprecedented time for humanity, but as we've done with many things before, we will prevail so long as we are kind, loving, and open-minded to the world.
Much love.
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Seven words I thought I'd never write: "You should watch this Nick Fuentes monologue."
Sure hope $BRE.ax and $WA1.ax don't have some fatal flaw bc I just made them my 2 biggest positions
Most of the exploreco copper names on my radar have been weak these last few days. No real reason why they should go oversold with copper prices where they are. Taken as a group and ignoring any specific stories I like/dislike, the sub-sector suddenly looks very cheap.
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To be quite honest, this is a seriously concerning outlook. While it remains true that El Niño, even a very strong one, "tilts the odds" rather than guaranteeing outcomes, the current forecast suggests one heck of an odds tilt toward wet conditions--perhaps problematically so.
You fuckers had to victory lap $TWST et al 1 day before I get LTCG
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Long range career advice. (Won't help you get a job tomorrow, this is a ~10-20 year thing)
You want to run two processes. Your main loop:
1. Knock on doors, many outside your league, and get yourself in a room with the most competent people who will have you.
2. Work your ass off to be reliably useful to them. Like, really, _really_ hard. However hard you think you're working to be reliably useful, work ten times harder. Also, be cheerful.
3. Every once in a while pop your head out and go to step 1.
Your background loop: look around for weird asymmetric opportunities. A startup to found/join, a project to hack on, an angel investment into a friend's company, whatever. When your heart sings, jump on it. (You will fail a lot but that's fine so long as you handle failure well, I'll cover that in another post)
In exchange for working really hard you get two things. First, knowledge/experience-- you learn a ton. Second, relationships-- ppl will remember how great it was to work with you. Knowledge and relationships with competent ppl create crazy asymmetric opportunities. You then jump on those. (There is a lot of twitter slop about compounding, well this is what career compounding looks like.)
---
Now some failure modes. Do _not_ do this:
"I deserve much better than this company/role, I'm just going to begrudgingly collect a paycheck" --> first, you deserve what the market clears and that's that. Second, if you act this way you'll only hurt yourself. Your colleagues will remember you as a grouch and it will wreck the compounding loop. Third, it's a very unpleasant state to be in, and you should choose not to be in it.
"But I work at Home Depot, what's there to compound?" --> that's extremely shortsighted. Maybe you do a super good job helping a customer who then has an open spot and remembers you. Maybe your store manager becomes a regional manager and calls you. Maybe years down the line your quiet peer is looking for a partner to start their own store. Maybe none of this happens, but it doesn't matter because empirically ppl who try hard to be useful wherever they are tend to do great, and people who don't, don't. (Home Depot is a metaphor, obviously)
"I hate this place, I quit! And anyway they're a faceless corporation that will lay me off any time." --> don't do that. The company may be a faceless corporation, but your colleagues are not faceless. They bet on you, hopefully you did a great job, and now they depend on you. Leaving is never easy, but do it in a way that respects the trust ppl put in you.
"Everyone around me is an idiot, I hate this!" --> maybe they are, or maybe you're not ready and some day will discover you were wrong about this. In any case you can learn from everyone and everything. So do that and be useful, don't break the compounding loop because opportunities will surprise you and things are often not what they seem.
“_I_ should have been promoted not that other guy/why is my manager layering me, screw this!” --> every time that happened i eventually understood I deserved it, you probably do too. Don’t hold grudges, do your best to figure out how to learn from this and move on, it will make sense eventually.
P.S. it helps if you’re a little talented.
One of the most important lessons I’ve learned is when you see signs of a potential freak deposit, you generally just want to HODL and buy dips.
For context, the storied Hole #7 at Voisey's Bay returned 104m at 3.9% Ni, 2.8% Cu, and 0.14% Co (6.80% NiEq at today's spot prices without factoring in recoveries), or 708 %·m NiEq.
25TK0562A intercept of 46.43m at 27.39% NiEq yields 1,272 %·m NiEq. Simply stunning.
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You're looking live at El Niño going "full-tilt" to start meteorological fall. Once in a lifetime event.
Three monster hurricanes in E. Pacific w/Hawaii splitting the uprights.
Moisture from Hurricane Marie is going to inundate U.S. desert Southwest with major monsoon!
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This is not widely understood by US and western investors.
We will know it is widely understood by US and western investors when they begin ferociously bidding gold higher on rising rates.
Let’s watch.
PS: My friends and clients in LatAm reading this be like 👇
Replying to @NorthstarCharts
Nothing more bullish for gold and silver than rates rising on an insolvent government that has a printing press
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.@swell_school recently asked me “Given what happened to people’s bodies when cheap calories became widely available, what do you think will happen to people’s brains as cheap thinking becomes widely available?” and I cannot stop thinking about it.
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Life is simple,
Make money from Americans.
Live in Asia.
Vacation in Europe.
Facts
85% of global GDP is downstream of sex. Every status game and social hierarchy is underpinned by it. Often people don’t even realize it until they are old and dying.
Biggest TAM by far is Sexbots. That alone will justify $20T of capex.
Longevity is a close second but what’s the point of living if you ain’t fucking.























