Studying the evolution of viruses, microbes, their hosts and beyond at Tel-Aviv University.
Israel
Joined June 2017
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Heartbroken and shocked. Talented and wonderful Liam who was about to start her Master's degree in my lab, was killed in an accident in Thailand. שבורת לב והמומה. ליאם המוכשרת והמבריקה שעמדה להתחיל תואר שני במעבדה שלי, נהרגה בתאונת דרכים בתאילנד.
ynet.co.il/news/article/hj4c…
Given incredibly difficult, conflict-filled years,it makes me proud to present @BZman101 beautiful work on intra-host evolution in SARS-CoV-2. Briefly,we find evolution differs among patients: in some nothing happens; in others rampant adaptive evolution. academic.oup.com/ve/article/…
The cool thing is that the cheater virus cheats other intact viruses! So it overcomes host defenses either inherently or by relying on co-infection with intact virus...
5. Finally we speculate that cheaters are probably very common and may even serve as stepping stones on the way to generate novel forms of viruses... Stay tuned!
4. This is like pulling the strings of a marionette - cheaters change one part of the replication cycle and helpers compensate, all with the "aim" of producing more cheater progeny.
3. When cheaters are evolved, helper mutations are added onto the genome. If a cheat is defective in replication, we find that helpers alter lysis and entry. And when a cheat is defective in lysis, we find helpers alter replication.
2. We find that cheater viruses of the MS2 bacteriophage occur in a really small region of the genome, where there are three overlapping genetic functions. This is normally a conserved region but cheats... overcome the challenge.
1. Cheaters are both defective viruses, but outcompete the WT virus when both viruses co-infect a cell. Who would have thought viruses could be so sly?
Science is solace these days and what could be better than studying cheater viruses??
Proud to share our new work that probes what happens when you evolve a point mutant cheater virus. w/ @ugophna
biorxiv.org/content/10.1101/…
SternLab @sternadi.bsky.social retweeted
״אתה מרגיש שיש לך מוסר יהודי״?
אין מה לומר יותר. רק לבכות.
#סוףלהפקרה
SternLab @sternadi.bsky.social retweeted
״המחיר שנשלם על החזרת החטופים יהיה יקר, אבל המחיר שנשלם על אי החזרתם יהיה יקר בהרבה.
כי לעולם לא נתאושש כעם. לא נוכל לטעון שאנחנו האומה שמקדשת את החיים.
אז באמת נפסיד. כי לא נזהה את עצמנו. נביט במראה ונראה אדם זר מביט בנו בחזרה.״
Heartbroken to share that Yagev Buchshtab, brother of PhD student Nufar, was murdered in Hamas captivity. Too much unbearable pain. This should not have ended, or started, this way.
SternLab @sternadi.bsky.social retweeted
הסטודנטים והסטודנטיות מפסיקים לשתוק. עסקת חטופים עכשיו!
מחר, 8.5, בשעה 12:00, נקיים הפגנה באוניברסיטאות בדרישה ברורה: עסקה עכשיו!
אנחנו מתנגדים להפקרת החטופים, חלקם שותפים שלנו לספסל הלימודים. כל אחד מאיתנו היה יכול להיות במקומם. אי אפשר להמשיך כרגיל בלעדיהם.
יש עסקה על השולחן. הממשלה חייבת לעשות הכל כדי להחזיר את כולם הביתה. תפסיקו לשחק בחיי אדם!
באוניברסיטה העברית - קמפוס הר הצופים | פורום
אוניברסיטת בן גוריון - שער סורוקה
SternLab @sternadi.bsky.social retweeted
80 days ago @SternLab posted this video by her student Nufar Buchstab, a plea for help regarding her brother Yagev Buchstab who was being held hostage in Gaza for 80 days. It's now 160 days.
SternLab @sternadi.bsky.social retweeted
IMO Israel has implemented more measure to prevent civilian casualties in urban warfare than any other military in the history of war. This includes many measure the U.S. has (or has not) taken in wars & battles but also many measures no military in the world has ever taken. 🧵
SternLab @sternadi.bsky.social retweeted
Announcing the Social Lives of Viruses 2024!
Do you study social evolution in viruses? Do you want to?
Join us in Puerto Rico this June for a 50-person meeting dedicated to viral sociality. All costs covered.
Apply here: forms.gle/sHTEcHJjryDhHqZu9
#LoveVirology
#SocialViruses
Our paper is now out nature.com/articles/s41467-0…
@SheriHarari @Daniellemlrs @shay_fleishon @BursteinLab
I want to be happy but my heart is still torn to pieces with hostages incl. kids,women,elderly, being held for 107 days.
Millions of SARS-CoV-2 seqs out there..what info do they hide? Combining phylogeny & deep learning we infer hundreds of chronic infections & show they predict future evolution. Want to know how? 🧵
biorxiv.org/cgi/content/shor…
@SheriHarari @Daniellemlrs @shay_fleishon @BursteinLab
