A new review just out with John Diffley and Janet Iwasa provides high resolution videos of the earliest stages of DNA replication in eukaryotes, the formation of pre-Replicative Complexes. Comparison of mechanisms in yeast and human cells is presented. See rdcu.be/et5Uh
New DNA sequencing method
Extremely clever new NGS tech from Roche 🧬
If it's hard to discriminate between nucleic acids accurately with a nanopore, why not synthesize a new polymer off a DNA template that is easier to sequence?
It's an intuitively simple idea, but took *a ton* of creative nucleic acid chemistry + enzyme engineering to design modified NTPs and create polymers of them.
It's been very interesting to see Roche move into the NGS market, and time will tell how this stacks up with the growing set of totally orthogonal approaches people are cooking up for sequencing tech.
It feels like we are entering another renaissance for biological measurement infrastructure—which is super important.
“Progress depends on the interplay of techniques, discoveries, and ideas, probably in that order." - Sydney Brenner
(These animations of sequencing tech will never get old to me. What a time to be a biologist!)
Interesting cancer meeting @CSHL Banbury Center
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Bruce Stillman retweeted
Meet O° – a collection of shoes and textiles whose creation and reincarnation starts and ends with biology.
100% biodegradable. 0% petrochemicals. 0% microplastics. 0% forever chemicals. No assemblies. No glues.
Here’s to a future where products can grow from—and reincarnate into—plant matter.
OXMAN is initiating discussions with potential partners, investors, and brand collaborators to bring the production of O° shoes and textiles to scale and to market. We look forward to hearing from you.
Press release here
prnewswire.com/news-releases…
Learn more here
oxman.com/projects/o0
Contact us here
oxman.com/contact
Bruce Stillman retweeted
Congratulations to Bruce Stillman of @CSHL on winning the ASBMB's Stadtman Award. Join us in Hemisfair Ballroom C2-3 for his award lecture, happening now! #DiscoverBMB
Bruce Stillman retweeted
I am happy to announce that we've recently posted our new manuscript, titled: ‘Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function’ on BioRxiv (biorxiv.org/content/10.1101/…). We hope you enjoy! Tweetorial below:
Bruce Stillman retweeted
In conclusion, we hope this demonstrates the potential for atomically-accurate structure prediction for the full range of important biomolecules and their interactions using AlphaFold-like methods!
storage.googleapis.com/deepm…
6/7
Important new click chemistry, particularly for biological based compounds
Iterating on sulfur fluoride exchange, K. Barry Sharpless and @HarborSpring have introduced phosphorus fluoride exchange for building complex products from a central phosphorus hub. ‘Just one step to the left and the world is different,’ says Sharpless.
chemistryworld.com/news/intr…
Bruce Stillman retweeted
Please take a moment to read CSHL President and CEO @StillmanBruce’s essay on the crucial need to invest not only in the bold visions of our current scientists but also those of future scientists who will lead the way into new frontiers. cshl.edu/presidents-essay-br…
Bruce Stillman retweeted
Congratulations to Associate Professor Jessica @tollkuhn on being chosen to receive one of @PershingSqFdn’s MIND Prizes. Her project highlights the pioneering aspect of her research on how sex hormones affect the body throughout our lifetimes.
cshl.edu/jessica-tollkuhn-wi…
Remarkable that an elected representative can not understand simple logic
State Sen. Nathan Dahm (R-OK) has penned several bills loosening gun restrictions, including the nation’s first anti-red flag law. He thinks these bills protect the Second Amendment – and that they make us safer. We think it's probably one or the other. Watch it on @AppleTVPlus.
Bruce Stillman retweeted
Two terrible earthquakes hit southeastern part of Turkey, in particular my hometown Samandag and Hatay had a lot of damage with currently minimal rescue and support, leaving many friends and relatives under collapsed buildings and others outside in cold weather and fear.
Great evolution story
A new preprint on our first evolution project, related to DNA methylation!
In this tweetorial, I'd like to share a brief story of how the project was developed. The origin of the project traces back to our former collaboration with David Allis. 1/
biorxiv.org/cgi/content/shor…
Bruce Stillman retweeted
Are you interested in doing a postbac? Join us tomorrow 2/1 for a Q&A about our PREP program! For program eligibility information, check our website. cshl.edu/education/prep/
A new review article is now available online | Home authors.elsevier.com/a/1gP-f…
A really talented scientist who relished new ideas and concepts and contributed major biological insight. Dave’s legacy will endure, as will the memory of a great and generous person.
Bruce Stillman retweeted
70 years ago the structure of the double helix of DNA was discovered. Now we understand how chromosomes replicate in great detail..
Biologist and biochemist,@StillmanBruce, talks us through the mind-boggling world of DNA replication..
#DNA
#Genetics
bit.ly/3IjIjbl