@Structure_CP

Structure is a monthly publication of @CellPressNews dedicated to research at the cutting edge of #structuralbiology. Tweets are by the Editors.

 Cambridge, MA, USA
cell.com/structure/home
Joined August 2012
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Online now! Structural analysis of de novo-designed binders targeting the closed state of HSP90 dlvr.​it/TVxXTq
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Online now! Molecular mechanism of KRAS binding to BRAF and its regulation by the BRAF-specific region dlvr.​it/TVtQzB
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A missing piece of the WFC trafficking complex revealed by cryo-EM dlvr.​it/TVnZd9
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Q&A with Christopher O. Barnes dlvr.​it/TVnVYb
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Meet the author: Nadia Izadi-Pruneyre dlvr.​it/TVnNmY
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Structures of the human sodium-citrate cotransporter NaCT with and without substrates dlvr.​it/TVnDws
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γ-glutamyl carboxylase inhibition by Anisindione dlvr.​it/TVljjk
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Shared ligand-blocking mechanism but distinct conformational modulation by α5-targeting antibodies BIIG2 and MINT1526A dlvr.​it/TVlcnB
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Structural plasticity drives convergent evolution and functional diversification of GNAT polyamine acetyltransferases dlvr.​it/TVlQCj
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Structural determinants of endopilus assembly, stability, and functional specificity in bacterial type II secretion dlvr.​it/TVlGGQ
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Morphotype-resolved 3D morphometry reveals a structure-density-location coupling in mitochondrial networks dlvr.​it/TVkrRd
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Cryo-EM structure of the WDR11-FAM91A1-C17orf75 complex involved in retrograde trafficking dlvr.​it/TVkkm9
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Conformational signatures of native ligand and pharmacochaperone binding in rhodopsin dlvr.​it/TVkfFm
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Ligand-dependent interdomain rearrangements drive catalysis by acetyl-CoA synthetases dlvr.​it/TVkWWv
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Online now! Virulence gene regulation in Pseudomonas aeruginosa is mediated by a novel hinge motion in the signaling helix of GacS histidine kinase dlvr.it/TVhvPM
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Online now! Reconstructing hidden GPCR conformations and ligand binding modes through integrative DEER modeling dlvr.it/TVhn4w

Reconstructing hidden GPCR conformations and ligand binding modes through integrative DEER modeling

Belyaeva and Elgeti present an integrative modeling pipeline for proteins that combines experimental DEER data with deep-learning techniques and short molecular dynamics simulations. Application to...

cell.com
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Online now! Chaperoning by dynamic encasement: Structural basis of linker histone H1 nuclear import dlvr.it/TVf4qn

Chaperoning by dynamic encasement: Structural basis of linker histone H1 nuclear import

Combining cryo-EM and molecular dynamics, Fu et al. show how two importins form an acidic cage around the extremely basic linker histone H1 for nuclear import. Rapidly exchanging contacts shield the...

cell.com
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Online now! Structures of distinct human acetylcholinesterase tetramer forms in complex with synaptic anchoring proteins dlvr.it/TVbgWl
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Online now! Molecular basis of metal transport by human ZnT10 dlvr.it/TVbY70
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Online now! Cryo-electron tomography of functionally validated synapses in human induced neurons dlvr.it/TVY02m

Cryo-electron tomography of functionally validated synapses in human induced neurons

Houcek et al. investigated the function and structure of synapses formed between induced human neurons using electrophysiology and cryo-ET. They compared synapse function between iNs off and on EM...

cell.com
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