NEW: Amgen and AstraZeneca cancer drugs used together extended survival for patients with an aggressive lung cancer, results shown at the ESMO conference. $AMGN Positive trial results could bolster both drugmakers' oncology sales and support wider use of the treatments.

JUST IN: J&J reports trial data showing its prostate cancer drug Erleada, used around surgery, lowered the chance of relapse or death 62% compared with surgery only. $JNJ Strong results may help J&J pursue approval for patients with earlier, high-risk disease.

NEW: Hedge funds have built their largest bearish positions on the euro since March 2020 as French political turmoil unsettles European markets. Heavy short positioning shows how much investors fear French instability could weigh on the single currency.

NEW: Brent crude futures close at $116.72 a barrel, gaining $3.55, or 3.14%, on the day. A jump at this level raises fuel costs for consumers and industry and tends to lift energy producers.

JUST IN: Infosys trims its full-year revenue outlook as clients keep reining in budgets for big technology projects. $INFY It suggests weak demand across IT services, which could weigh on Indian outsourcing peers.

NEW: American Express will lay off 5% of its workforce worldwide as CEO Steve Squeri works to contain growing expenses, Bloomberg reports. $AXP The cut signals pressure on costs at the card issuer and could shape how investors read its margins.

NEW: Volkswagen pauses spending on an Indian electric-vehicle program until it knows more about a possible tie-up with Sajjan Jindal's JSW Group, Bloomberg reports. It points to a delay in the German carmaker's India EV push while the possible JSW partnership stays unresolved.

JUST IN: President Trump holds off on national-security tariffs covering wind turbines and the components that go into them, Bloomberg reports. Wind developers and turbine makers avoid a possible jump in import costs, at least for the moment.

JUST IN: Western Digital projects earnings above expectations and raises its dividend as AI drives demand for data storage. $WDC It suggests AI spending is lifting storage hardware makers, not just chip and cloud companies.