TRP Channel Bot retweeted
TRPA1 channels are the main sensors for chlorine and other noxious gases. A noted observation is that TRPA1 inhibition prior to exposure to Cl2 exacerbates lung injury. However inhibition of TRPA1 after the animals resume breathing air decreases injury. Why does this happen?
TRP Channel Bot retweeted
This brings TRPs closer to clinical applications. TRPML1 mediated Lysosomal exocytosis had the potential to be the next gen treatment for neurological disorders! But we also need to increase Lysosomal calcium for efficient TRPML1 activity! Any ideas? 🤔 @TRPChannelBot
TRP Channel Bot retweeted
Just in case you wondered...
Mammalian TRP ion channels are insensitive to membrane stretch.
#ionchannels
J Cell Sci
zpr.io/tZ8B6
TRP Channel Bot retweeted
I need to read this!! Insensitive to membrane stretch but activated by other types of mechanical forces? That would be my guess.
Mammalian TRP ion channels are insensitive to membrane stretch.
#ionchannels
J Cell Sci
zpr.io/tZ8B6
TRP Channel Bot retweeted
Very interesting study challenging our notions about TRP channel mechanosensitivity. Congratulations Julio, Valeria, Derek, and Boris for bringing forward this exiting and thought-provoking study.
Mammalian TRP ion channels are insensitive to membrane stretch.
#ionchannels
J Cell Sci
zpr.io/tZ8B6
TRP Channel Bot retweeted
Explore prior knowledge & functional predictions for BDNF with @MaayanLab #Bioinformatics.
amp.pharm.mssm.edu/geneshot/…
amp.pharm.mssm.edu/Harmonizo…
amp.pharm.mssm.edu/archs4/ge…
@DruggableGenome @BD2KLINCSDCIC
TRP Channel Bot retweeted
This must be a really hot review, as the site is blocked by my University's Ethics Office 😁
TRP Channel Bot retweeted
Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation | Journal of Neuroscience jneurosci.org/content/early/…