@Telencephale

Assistant Professor @UAMShealth Department of Neuroscience Choroid plexus & NSCs in neuroinflammation

 Little Rock, Arkansas
nicaiselab.org
Joined September 2010
  • Tweets424
  • Following1.2K
  • Followers478
3Media
Multi-omics profiling of the choroid plexus reveals developmental cell… sciencedirect.com/science/ar…
2
103
nature.com/articles/s41593-0…

Periventricular gradient pathology is linked to ependymal reactivity and cell adhesion disruption...

Nature Neuroscience - This study identifies ependymal dysfunction as a mechanism linking inflammatory cerebrospinal fluid to increased ventricular permeability and periventricular pathology in...

nature.com
1
3
154
We are hiring! The Willis and Nicaise Labs at University of Arkansas for Medical Sciences are hiring a research assistant to aid in managing our new labs. If interested please apply here by October 22nd: lnkd.in/g2gYPbPu

LinkedIn

This link will take you to a page that’s not on LinkedIn

lnkd.in
2
3
251
Alexandra Nicaise retweeted
Luis J. Castro-Vega@LuisJaimeCastr3Aug 17
biorxiv.org/content/10.64898…

The brain-meningeal interface functions as a reservoir and entry site for brain parenchymal...

Microglia are regarded as self-maintaining brain parenchymal macrophages without contribution from adult hematopoiesis. Nevertheless, peripheral macrophage engraftment into the brain has been...

biorxiv.org
6
28
5,584
Alexandra Nicaise retweeted
Cell Reports@CellReportsAug 14
TTN+ macrophages are enriched in the human choroid plexus in Alzheimer’s disease dlvr.it/TV1RwV

TTN+ macrophages are enriched in the human choroid plexus in Alzheimer’s disease

Bhatta et al. profile the human choroid plexus by single-nucleus RNA sequencing and spatial transcriptomics, identifying a TTN-expressing macrophage population within the stroma. These cells are...

cell.com
11
35
5,542
Alexandra Nicaise retweeted
Tess Dierckx@TessDierckxAug 7
How does aging impair OPC function? The core circadian factor BMAL1 is disrupted in aging and MS, driving metabolic deficits, senescence, and altered time-of-day dynamics. Exciting part? Time-based BMAL1-SIRT2 targeting optimizes demyelination recovery. cell.com/neuron/fulltext/S08…

Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple...

Aging disrupts the circadian transcription factor BMAL1 in oligodendrocyte precursor cells (OPCs), with Bmal1 loss driving OPC metabolic dysfunction and senescence. Evening-timed therapeutic interv...

cell.com
2
8
2
25
3,867
Alexandra Nicaise retweeted
Trends in Immunology@TrendsImmunoAug 7
Antigen presentation at the blood–brain barrier amplifies neuroinflammation dlvr.it/TTvGXB #immunology

Antigen presentation at the blood–brain barrier amplifies neuroinflammation

Immune surveillance of the central nervous system (CNS) is regulated by the brain barriers. Antigen presentation at the blood–brain barrier (BBB) has been proposed to promote antigen-specific T-cell...

cell.com
10
31
3,196
Alexandra Nicaise retweeted
Aging Science News
@AgingBiologyJul 29
Mitochondrial metabolism and epigenetic crosstalk drive SASP nature.com/articles/s41586-0…

Mitochondrial metabolism and epigenetic crosstalk drive SASP

Nature - In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these...

nature.com
1
25
1
73
5,392
Alexandra Nicaise retweeted
Villeda Lab@VilledaLabJun 10
cell.com/immunity/fulltext/S…

Aged circulating CD8+ T cells and their secreted factors drive cognitive decline

The role of non-infiltrating aged CD8+ T cells in brain function remains unclear. Sucharov et al. reveal that aged circulating cytotoxic T cells are drivers of age-related cognitive decline. Removal...

cell.com
2
1
206
Alexandra Nicaise retweeted
John Lukens@LukensJohnRJun 10
Persistent and transient senescent cells contribute to brain-barrier development: @CellCellPress cell.com/cell/fulltext/S0092…
1
18
55
2,778
Alexandra Nicaise retweeted
Nalini Rao@NaliniRRaoMay 29
Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9 🔗 cell.com/cell/fulltext/S0092…

Physiological brain clearance architecture revealed by neuronal protein tracing

Neuronal protein tracing, unlike CSF tracers, reveals that brain clearance follows a “nearest exit” principle through distinct border immune niches disrupted differently by disease.

cell.com
7
35
6
127
26,463
Alexandra Nicaise retweeted
John Lukens@LukensJohnRMay 29
Decoding the spatiotemporal development of human meninges @CellCellPress cell.com/cell/fulltext/S0092…
40
1
111
5,831
Alexandra Nicaise retweeted
John Lukens@LukensJohnRApr 23
Gateways for myeloid cell entry into the central nervous system: Neuron cell.com/neuron/fulltext/S08…
30
87
3,747
Alexandra Nicaise retweeted
Neuron@NeuroCellPressMar 31
Online now: Piezo1-mediated mechanotransduction in choroid plexus epithelial cells governs ciliogenesis and cerebrospinal fluid homeostasis dlvr.it/TRp570
12
46
3,124
Alexandra Nicaise retweeted
Science Immunology@SciImmunologyMar 27
Intestinal epithelial cells upregulate MHC II and induce pathogenic T cells that migrate to the CNS, promoting symptoms of #MultipleSclerosis in mouse models. Learn more in Science #Immunology: scim.ag/4rT0HuP #IECs
2
37
115
6,329
Alexandra Nicaise retweeted
Ruslan Rust
@rust_ruslanMar 23
Cool preprint! The authors map choroid plexus vasculature in 3D and find endothelial Piezo1 activation triggers network-wide calcium waves that shift across development, suggesting mechanotransduction shapes blood-brain barrier function. biorxiv.org/content/10.64898…
1
25
1
100
5,239
Alexandra Nicaise retweeted
Charles Brenner, PhD
@CharlesMBrennerMar 18
it was always dumb to talk about killing so called zombie cells in the context of healthy aging
TimePie (focus on anti-aging science)@TimePieChinaMar 18
#Senolytic therapies may carry previously underappreciated neurological risks. @uconnhealth researchers found #dasatinib + #quercetin combination unexpectedly induces white matter damage in the central nervous system of healthy mice, confirmed both in vivo and in vitro.
4
9
1
21
4,057
Alexandra Nicaise retweeted
John Lukens@LukensJohnRJan 21
Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins @NatureNeuro nature.com/articles/s41593-0…
1
28
1
124
6,007
Alexandra Nicaise retweeted
Aging Science News
@AgingBiology16 Dec 2025
The antiviral Interferon pathway drives astrocyte aging and motor decline biorxiv.org/content/10.1101/…

The antiviral Interferon pathway drives astrocyte aging and motor decline

Aging encompasses low-level inflammation and motor decline. Astrocytes are neuroregulatory glial cells that change in aging, particularly in the cerebellum, which is essential for movement coordina...

biorxiv.org
1
3
31
3,851
Alexandra Nicaise retweeted
Lucas Barea@lucasbarea17 Dec 2025
Mitochondrial RNA cytosolic leakage drives the SASP nature.com/articles/s41467-0…

Mitochondrial RNA cytosolic leakage drives the SASP

Nature Communications - Here the authors show that mitochondrial RNA leaks into the cytosol of senescent cells through sublethal apoptosis, driving inflammation. Blocking this pathway improves...

nature.com
3
7
489
Load more