Assistant Professor of Computational Medicine at UNC-Chapel Hill. Interested in good discussions and collaborations! Other: @christophrau.bsky.social
Chapel Hill, NC
Joined July 2016
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Christoph Rau retweeted
Check out our latest from the Patterson Lab - a method to assess cardiomyocyte division along with many other useful metrics all from the same heart: cell.com/cell-reports-method…
Hoping the bench top protocol is not far behind! @ScientistSwift
Christoph Rau retweeted
📢Looking for postdoc to study biomechanics of chromatin & role of histones as stress sensors @UCLA. Other projects #Cardiovascular #Epigenetics, #HFpEF, #Circadian biology. Email Tom Vondriska for details…Please RT!
#postdoc #academicchatter @dgsomucla
pubmed.ncbi.nlm.nih.gov/3876…
Myocardial infarctions change both cell-specific expression and cell-type abundance. Can we algorithmically disentangle these two signals in bulk RNAseq data?
Yes!
Excited to share the first paper from the Rau lab, led by @BrianGural!
biorxiv.org/content/10.1101/…
He then showed that the initial enriched GO terms in the DGE b/t WT MI and KO MI mice, largely genes associated with fibroblast abundance (which was old news!) lost significance while novel genes involved in fundamental heart integrity were highlighted as crucially important!
We have a lot more happening with this approach, with exciting results to share shortly about what happens when you apply this algorithm to-scale across 100s of RNAseq datasets. We want to understand the noise that cell-type composition adds to our analyses!
Thanks again to @BrianGural who led this project, along with all our collaborators in the Brian Jensen, Tom Vondriska, Michaela Patterson, and Caitlin O'Meara labs.
biorxiv.org/content/10.1101/…